Surgical debulking of podoconiosis nodules and its impact on quality of life in Ethiopia.
Background In Ethiopia, severe lymphedema and acute dermato-lymphangio-adenitis (ADLA) of the legs as a consequence of podoconiosis affects approximately 1.5 million people. In some this condition may lead to woody-hard fibrotic nodules, which are resistant to conventional treatment. We present a se...
Published in: | PLOS Neglected Tropical Diseases |
---|---|
Main Authors: | , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Public Library of Science (PLoS)
2021
|
Subjects: | |
Online Access: | https://doi.org/10.1371/journal.pntd.0009053 https://doaj.org/article/65ed33dc64d34efbaea727836d154f84 |
id |
ftdoajarticles:oai:doaj.org/article:65ed33dc64d34efbaea727836d154f84 |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:65ed33dc64d34efbaea727836d154f84 2023-05-15T15:09:23+02:00 Surgical debulking of podoconiosis nodules and its impact on quality of life in Ethiopia. Wendemagegn Enbiale Kristien Verdonck Melesse Gebeyehu Johan van Griensven Henry J C de Vries 2021-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0009053 https://doaj.org/article/65ed33dc64d34efbaea727836d154f84 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0009053 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0009053 https://doaj.org/article/65ed33dc64d34efbaea727836d154f84 PLoS Neglected Tropical Diseases, Vol 15, Iss 1, p e0009053 (2021) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2021 ftdoajarticles https://doi.org/10.1371/journal.pntd.0009053 2022-12-31T11:56:29Z Background In Ethiopia, severe lymphedema and acute dermato-lymphangio-adenitis (ADLA) of the legs as a consequence of podoconiosis affects approximately 1.5 million people. In some this condition may lead to woody-hard fibrotic nodules, which are resistant to conventional treatment. We present a series of patients who underwent surgical nodulectomy in a resource-limited setting and their outcome. Methods In two teaching hospitals, we offered surgical nodulectomies under local anaesthesia to patients with persisting significant fibrotic nodules due to podoconiosis. Excisions after nodulectomy were left to heal by secondary intention with compression bandaging. As outcome, we recorded time to re-epithelialization after surgery, change in number of ADLA episodes, change in quality of life measured with the Dermatology Quality of Live Index (DQLI) questionnaire, and recurrence rate one year after surgery. Results 37nodulectomy operations were performed on 21 patients. All wounds re-reepithelialised within 21 days (range 17-42). 4 patients developed clinically relevant wound infections. The DLQI values were significantly better six months after surgery than before surgery (P<0.0001). Also the number of ADLA episodes per three months was significantly lower six months after surgery than before surgery (P<0.0001). Conclusion Nodulectomy in podoconiosis patients leads to a significant improvement in the quality of life with no serious complications, and we recommend this to be a standard procedure in resource-poor settings. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 15 1 e0009053 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Wendemagegn Enbiale Kristien Verdonck Melesse Gebeyehu Johan van Griensven Henry J C de Vries Surgical debulking of podoconiosis nodules and its impact on quality of life in Ethiopia. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Background In Ethiopia, severe lymphedema and acute dermato-lymphangio-adenitis (ADLA) of the legs as a consequence of podoconiosis affects approximately 1.5 million people. In some this condition may lead to woody-hard fibrotic nodules, which are resistant to conventional treatment. We present a series of patients who underwent surgical nodulectomy in a resource-limited setting and their outcome. Methods In two teaching hospitals, we offered surgical nodulectomies under local anaesthesia to patients with persisting significant fibrotic nodules due to podoconiosis. Excisions after nodulectomy were left to heal by secondary intention with compression bandaging. As outcome, we recorded time to re-epithelialization after surgery, change in number of ADLA episodes, change in quality of life measured with the Dermatology Quality of Live Index (DQLI) questionnaire, and recurrence rate one year after surgery. Results 37nodulectomy operations were performed on 21 patients. All wounds re-reepithelialised within 21 days (range 17-42). 4 patients developed clinically relevant wound infections. The DLQI values were significantly better six months after surgery than before surgery (P<0.0001). Also the number of ADLA episodes per three months was significantly lower six months after surgery than before surgery (P<0.0001). Conclusion Nodulectomy in podoconiosis patients leads to a significant improvement in the quality of life with no serious complications, and we recommend this to be a standard procedure in resource-poor settings. |
format |
Article in Journal/Newspaper |
author |
Wendemagegn Enbiale Kristien Verdonck Melesse Gebeyehu Johan van Griensven Henry J C de Vries |
author_facet |
Wendemagegn Enbiale Kristien Verdonck Melesse Gebeyehu Johan van Griensven Henry J C de Vries |
author_sort |
Wendemagegn Enbiale |
title |
Surgical debulking of podoconiosis nodules and its impact on quality of life in Ethiopia. |
title_short |
Surgical debulking of podoconiosis nodules and its impact on quality of life in Ethiopia. |
title_full |
Surgical debulking of podoconiosis nodules and its impact on quality of life in Ethiopia. |
title_fullStr |
Surgical debulking of podoconiosis nodules and its impact on quality of life in Ethiopia. |
title_full_unstemmed |
Surgical debulking of podoconiosis nodules and its impact on quality of life in Ethiopia. |
title_sort |
surgical debulking of podoconiosis nodules and its impact on quality of life in ethiopia. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2021 |
url |
https://doi.org/10.1371/journal.pntd.0009053 https://doaj.org/article/65ed33dc64d34efbaea727836d154f84 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 15, Iss 1, p e0009053 (2021) |
op_relation |
https://doi.org/10.1371/journal.pntd.0009053 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0009053 https://doaj.org/article/65ed33dc64d34efbaea727836d154f84 |
op_doi |
https://doi.org/10.1371/journal.pntd.0009053 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
15 |
container_issue |
1 |
container_start_page |
e0009053 |
_version_ |
1766340590200422400 |