Mycobacterium leprae genomes from naturally infected nonhuman primates.
Leprosy is caused by the bacterial pathogens Mycobacterium leprae and Mycobacterium lepromatosis. Apart from humans, animals such as nine-banded armadillos in the Americas and red squirrels in the British Isles are naturally infected with M. leprae. Natural leprosy has also been reported in certain...
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ftdoajarticles:oai:doaj.org/article:65c8809b1c3a43259fcd4ce3485cef6e 2023-05-15T15:13:48+02:00 Mycobacterium leprae genomes from naturally infected nonhuman primates. Tanvi P Honap Luz-Andrea Pfister Genevieve Housman Sarah Mills Ross P Tarara Koichi Suzuki Frank P Cuozzo Michelle L Sauther Michael S Rosenberg Anne C Stone 2018-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0006190 https://doaj.org/article/65c8809b1c3a43259fcd4ce3485cef6e EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC5790234?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0006190 https://doaj.org/article/65c8809b1c3a43259fcd4ce3485cef6e PLoS Neglected Tropical Diseases, Vol 12, Iss 1, p e0006190 (2018) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2018 ftdoajarticles https://doi.org/10.1371/journal.pntd.0006190 2022-12-31T16:23:10Z Leprosy is caused by the bacterial pathogens Mycobacterium leprae and Mycobacterium lepromatosis. Apart from humans, animals such as nine-banded armadillos in the Americas and red squirrels in the British Isles are naturally infected with M. leprae. Natural leprosy has also been reported in certain nonhuman primates, but it is not known whether these occurrences are due to incidental infections by human M. leprae strains or by M. leprae strains specific to nonhuman primates. In this study, complete M. leprae genomes from three naturally infected nonhuman primates (a chimpanzee from Sierra Leone, a sooty mangabey from West Africa, and a cynomolgus macaque from The Philippines) were sequenced. Phylogenetic analyses showed that the cynomolgus macaque M. leprae strain is most closely related to a human M. leprae strain from New Caledonia, whereas the chimpanzee and sooty mangabey M. leprae strains belong to a human M. leprae lineage commonly found in West Africa. Additionally, samples from ring-tailed lemurs from the Bezà Mahafaly Special Reserve, Madagascar, and chimpanzees from Ngogo, Kibale National Park, Uganda, were screened using quantitative PCR assays, to assess the prevalence of M. leprae in wild nonhuman primates. However, these samples did not show evidence of M. leprae infection. Overall, this study adds genomic data for nonhuman primate M. leprae strains to the existing M. leprae literature and finds that this pathogen can be transmitted from humans to nonhuman primates as well as between nonhuman primate species. While the prevalence of natural leprosy in nonhuman primates is likely low, nevertheless, future studies should continue to explore the prevalence of leprosy-causing pathogens in the wild. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 12 1 e0006190 |
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Directory of Open Access Journals: DOAJ Articles |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Tanvi P Honap Luz-Andrea Pfister Genevieve Housman Sarah Mills Ross P Tarara Koichi Suzuki Frank P Cuozzo Michelle L Sauther Michael S Rosenberg Anne C Stone Mycobacterium leprae genomes from naturally infected nonhuman primates. |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Leprosy is caused by the bacterial pathogens Mycobacterium leprae and Mycobacterium lepromatosis. Apart from humans, animals such as nine-banded armadillos in the Americas and red squirrels in the British Isles are naturally infected with M. leprae. Natural leprosy has also been reported in certain nonhuman primates, but it is not known whether these occurrences are due to incidental infections by human M. leprae strains or by M. leprae strains specific to nonhuman primates. In this study, complete M. leprae genomes from three naturally infected nonhuman primates (a chimpanzee from Sierra Leone, a sooty mangabey from West Africa, and a cynomolgus macaque from The Philippines) were sequenced. Phylogenetic analyses showed that the cynomolgus macaque M. leprae strain is most closely related to a human M. leprae strain from New Caledonia, whereas the chimpanzee and sooty mangabey M. leprae strains belong to a human M. leprae lineage commonly found in West Africa. Additionally, samples from ring-tailed lemurs from the Bezà Mahafaly Special Reserve, Madagascar, and chimpanzees from Ngogo, Kibale National Park, Uganda, were screened using quantitative PCR assays, to assess the prevalence of M. leprae in wild nonhuman primates. However, these samples did not show evidence of M. leprae infection. Overall, this study adds genomic data for nonhuman primate M. leprae strains to the existing M. leprae literature and finds that this pathogen can be transmitted from humans to nonhuman primates as well as between nonhuman primate species. While the prevalence of natural leprosy in nonhuman primates is likely low, nevertheless, future studies should continue to explore the prevalence of leprosy-causing pathogens in the wild. |
format |
Article in Journal/Newspaper |
author |
Tanvi P Honap Luz-Andrea Pfister Genevieve Housman Sarah Mills Ross P Tarara Koichi Suzuki Frank P Cuozzo Michelle L Sauther Michael S Rosenberg Anne C Stone |
author_facet |
Tanvi P Honap Luz-Andrea Pfister Genevieve Housman Sarah Mills Ross P Tarara Koichi Suzuki Frank P Cuozzo Michelle L Sauther Michael S Rosenberg Anne C Stone |
author_sort |
Tanvi P Honap |
title |
Mycobacterium leprae genomes from naturally infected nonhuman primates. |
title_short |
Mycobacterium leprae genomes from naturally infected nonhuman primates. |
title_full |
Mycobacterium leprae genomes from naturally infected nonhuman primates. |
title_fullStr |
Mycobacterium leprae genomes from naturally infected nonhuman primates. |
title_full_unstemmed |
Mycobacterium leprae genomes from naturally infected nonhuman primates. |
title_sort |
mycobacterium leprae genomes from naturally infected nonhuman primates. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2018 |
url |
https://doi.org/10.1371/journal.pntd.0006190 https://doaj.org/article/65c8809b1c3a43259fcd4ce3485cef6e |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 12, Iss 1, p e0006190 (2018) |
op_relation |
http://europepmc.org/articles/PMC5790234?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0006190 https://doaj.org/article/65c8809b1c3a43259fcd4ce3485cef6e |
op_doi |
https://doi.org/10.1371/journal.pntd.0006190 |
container_title |
PLOS Neglected Tropical Diseases |
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12 |
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1 |
container_start_page |
e0006190 |
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