Expression of co-stimulatory molecules CD80 and CD86 is altered in CD14 + HLA-DR + monocytes from patients with Chagas disease following induction by Trypanosoma cruzi recombinant antigens

• Published in: Revista da Sociedade Brasileira de Medicina Tropical
• Main Authors: Ana Karine de Araújo Soares, Patrícia Areias Feitosa Neves, Maria da Glória Aureliano de Melo Cavalcanti, Sílvia Martins Marinho, Wilson de Oliveira Júnior, Joelma Rodrigues de Souza, Virginia Maria Barros de Lorena, Yara de Miranda Gomes
• Format: Article in Journal/Newspaper
• Language: English
• Published: Sociedade Brasileira de Medicina Tropical (SBMT)
• Subjects: Chagas disease; Immune response; Recombinant antigens; Arctic medicine. Tropical medicine; RC955-962; Arctic
• Online Access: https://doi.org/10.1590/0037-8682-0149-2016; https://doaj.org/article/65c1a98ee19345bea18aa0967b319a3e

Abstract INTRODUCTION The relationships between monocytes and lymphocytes through MHC class II molecules and costimulatory, are of utmost importance for the production of an efficient immune response. In this work, we assessed the expression of surface molecules CD80 and CD86 on CD14+HLA-DR+ monocytes from patients with Chagas disease. METHODS: The study population consisted of 31 patients with chronic clinical forms of Chagas disease. Patient blood samples were cultured in the presence of recombinant cytoplasmic repetitive antigen (CRA) and flagellar repetitive antigen (FRA). RESULTS: We found considerable differences in the expression profile of surface molecules involved in antigen presentation. CONCLUSIONS: CRA and FRA may contribute to host immune response evasion by Trypanozoma cruzi.