Investigator Argus X-12 study on the population of northern Croatia
Abstract X chromosome STR typing has emerged recently as a powerful tool, complementary to autosomal STR typing, in solving complex forensic and missing person cases. Investigator® Argus X-12 is a commercial product that allows co-amplification of 12 X chromosomal markers belonging to four linkage g...
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ftdoajarticles:oai:doaj.org/article:659fffe9549c4ab7870f2abcdfee7221 2023-05-15T16:31:11+02:00 Investigator Argus X-12 study on the population of northern Croatia Josip Crnjac Petar Ozretić Siniša Merkaš Martina Ratko Mateja Lozančić Marina Korolija Maja Popović Gordan Mršić https://doi.org/10.1590/1678-4685-GMB-2015-0261 https://doaj.org/article/659fffe9549c4ab7870f2abcdfee7221 EN eng Sociedade Brasileira de Genética http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572016005015102&lng=en&tlng=en https://doaj.org/toc/1678-4685 1678-4685 doi:10.1590/1678-4685-GMB-2015-0261 https://doaj.org/article/659fffe9549c4ab7870f2abcdfee7221 Genetics and Molecular Biology, Iss 0 X-STR forensic genetics Investigator® Argus X-12 population genetics northern Croatia Genetics QH426-470 article ftdoajarticles https://doi.org/10.1590/1678-4685-GMB-2015-0261 2022-12-31T15:20:08Z Abstract X chromosome STR typing has emerged recently as a powerful tool, complementary to autosomal STR typing, in solving complex forensic and missing person cases. Investigator® Argus X-12 is a commercial product that allows co-amplification of 12 X chromosomal markers belonging to four linkage groups (LGs). In this study, we analyzed by capillary electrophoresis blood samples from 100 females and 102 males from a population of northern Croatia. Statistical analysis included calculation of allele and haplotype frequencies, as well as forensic parameters. The most informative marker for the northern Croatia population was DXS10135 with PIC=0.9211 and a total of 27 alleles. The least polymorphic marker was DXS8378 with 6 alleles. The proportion of observed haplotypes from the number of possible haplotypes varied from 2.74–8.57% across all LGs, with LG1 being the most informative. Of the 11 tested world populations compared to the population of northern Croatia, significant differences in genetic distance (FST) were found for Greenlandic and all non-European populations. We found that all tested markers are in HWE and can thus be used for match probability calculation. Because of high combined power of discrimination in both men and women, Investigator® Argus X-12 is applicable for the northern Croatia population in routine forensic casework. Article in Journal/Newspaper greenlandic Directory of Open Access Journals: DOAJ Articles Genetics and Molecular Biology 40 1 80 83 |
institution |
Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
X-STR forensic genetics Investigator® Argus X-12 population genetics northern Croatia Genetics QH426-470 |
spellingShingle |
X-STR forensic genetics Investigator® Argus X-12 population genetics northern Croatia Genetics QH426-470 Josip Crnjac Petar Ozretić Siniša Merkaš Martina Ratko Mateja Lozančić Marina Korolija Maja Popović Gordan Mršić Investigator Argus X-12 study on the population of northern Croatia |
topic_facet |
X-STR forensic genetics Investigator® Argus X-12 population genetics northern Croatia Genetics QH426-470 |
description |
Abstract X chromosome STR typing has emerged recently as a powerful tool, complementary to autosomal STR typing, in solving complex forensic and missing person cases. Investigator® Argus X-12 is a commercial product that allows co-amplification of 12 X chromosomal markers belonging to four linkage groups (LGs). In this study, we analyzed by capillary electrophoresis blood samples from 100 females and 102 males from a population of northern Croatia. Statistical analysis included calculation of allele and haplotype frequencies, as well as forensic parameters. The most informative marker for the northern Croatia population was DXS10135 with PIC=0.9211 and a total of 27 alleles. The least polymorphic marker was DXS8378 with 6 alleles. The proportion of observed haplotypes from the number of possible haplotypes varied from 2.74–8.57% across all LGs, with LG1 being the most informative. Of the 11 tested world populations compared to the population of northern Croatia, significant differences in genetic distance (FST) were found for Greenlandic and all non-European populations. We found that all tested markers are in HWE and can thus be used for match probability calculation. Because of high combined power of discrimination in both men and women, Investigator® Argus X-12 is applicable for the northern Croatia population in routine forensic casework. |
format |
Article in Journal/Newspaper |
author |
Josip Crnjac Petar Ozretić Siniša Merkaš Martina Ratko Mateja Lozančić Marina Korolija Maja Popović Gordan Mršić |
author_facet |
Josip Crnjac Petar Ozretić Siniša Merkaš Martina Ratko Mateja Lozančić Marina Korolija Maja Popović Gordan Mršić |
author_sort |
Josip Crnjac |
title |
Investigator Argus X-12 study on the population of northern Croatia |
title_short |
Investigator Argus X-12 study on the population of northern Croatia |
title_full |
Investigator Argus X-12 study on the population of northern Croatia |
title_fullStr |
Investigator Argus X-12 study on the population of northern Croatia |
title_full_unstemmed |
Investigator Argus X-12 study on the population of northern Croatia |
title_sort |
investigator argus x-12 study on the population of northern croatia |
publisher |
Sociedade Brasileira de Genética |
url |
https://doi.org/10.1590/1678-4685-GMB-2015-0261 https://doaj.org/article/659fffe9549c4ab7870f2abcdfee7221 |
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greenlandic |
genre_facet |
greenlandic |
op_source |
Genetics and Molecular Biology, Iss 0 |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572016005015102&lng=en&tlng=en https://doaj.org/toc/1678-4685 1678-4685 doi:10.1590/1678-4685-GMB-2015-0261 https://doaj.org/article/659fffe9549c4ab7870f2abcdfee7221 |
op_doi |
https://doi.org/10.1590/1678-4685-GMB-2015-0261 |
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Genetics and Molecular Biology |
container_volume |
40 |
container_issue |
1 |
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80 |
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83 |
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1766020958169071616 |