Th-1, Th-2 Cytokines Profile among Madurella mycetomatis Eumycetoma Patients.
Eumycetoma is a progressive and destructive chronic granulomatous subcutaneous inflammatory disease caused by certain fungi, the most common being Madurella mycetomatis. The host defence mechanisms against fungi usually range from an early non-specific immune response to activation and induction of...
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ftdoajarticles:oai:doaj.org/article:659afafacb8f4ef0b0d1fad372efbb21 2023-05-15T15:10:03+02:00 Th-1, Th-2 Cytokines Profile among Madurella mycetomatis Eumycetoma Patients. Amre Nasr Amir Abushouk Anhar Hamza Emmanuel Siddig Ahmed H Fahal 2016-07-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0004862 https://doaj.org/article/659afafacb8f4ef0b0d1fad372efbb21 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC4951069?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0004862 https://doaj.org/article/659afafacb8f4ef0b0d1fad372efbb21 PLoS Neglected Tropical Diseases, Vol 10, Iss 7, p e0004862 (2016) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2016 ftdoajarticles https://doi.org/10.1371/journal.pntd.0004862 2022-12-31T12:34:24Z Eumycetoma is a progressive and destructive chronic granulomatous subcutaneous inflammatory disease caused by certain fungi, the most common being Madurella mycetomatis. The host defence mechanisms against fungi usually range from an early non-specific immune response to activation and induction of specific adaptive immune responses by the production of Th-1 and Th-2 cytokines. The aim of this study is to determine the levels of Th-1 and Th-2 cytokines in patients infected with Madurella mycetomatis, and the association between their levels and disease prognosis. This is a descriptive cross-sectional study conducted at the Mycetoma Research Centre, University of Khartoum, Sudan, where 70 patients with confirmed M. mycetomatis eumycetoma were enrolled; 35 with, and 35 without surgical excision. 70 healthy individuals from mycetoma endemic areas were selected as controls. The levels of serum cytokines were determined by cytometric bead array technique. Significantly higher levels of the Th-1 cytokines (IFN-γ, TNF-α, IL-1β and IL-2) were recorded in patients treated with surgical excision, compared to those treated without surgical excision. In contrast, the Th-2 cytokines (IL-4, IL-5, IL-6 and IL-10) were significantly lower in patients treated with surgical excision compared to those treated without surgical excision. In conclusion, the results of this study suggest that cell-mediated immunity can have a role to play in the pathogenesis of eumycetoma. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 10 7 e0004862 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Amre Nasr Amir Abushouk Anhar Hamza Emmanuel Siddig Ahmed H Fahal Th-1, Th-2 Cytokines Profile among Madurella mycetomatis Eumycetoma Patients. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Eumycetoma is a progressive and destructive chronic granulomatous subcutaneous inflammatory disease caused by certain fungi, the most common being Madurella mycetomatis. The host defence mechanisms against fungi usually range from an early non-specific immune response to activation and induction of specific adaptive immune responses by the production of Th-1 and Th-2 cytokines. The aim of this study is to determine the levels of Th-1 and Th-2 cytokines in patients infected with Madurella mycetomatis, and the association between their levels and disease prognosis. This is a descriptive cross-sectional study conducted at the Mycetoma Research Centre, University of Khartoum, Sudan, where 70 patients with confirmed M. mycetomatis eumycetoma were enrolled; 35 with, and 35 without surgical excision. 70 healthy individuals from mycetoma endemic areas were selected as controls. The levels of serum cytokines were determined by cytometric bead array technique. Significantly higher levels of the Th-1 cytokines (IFN-γ, TNF-α, IL-1β and IL-2) were recorded in patients treated with surgical excision, compared to those treated without surgical excision. In contrast, the Th-2 cytokines (IL-4, IL-5, IL-6 and IL-10) were significantly lower in patients treated with surgical excision compared to those treated without surgical excision. In conclusion, the results of this study suggest that cell-mediated immunity can have a role to play in the pathogenesis of eumycetoma. |
format |
Article in Journal/Newspaper |
author |
Amre Nasr Amir Abushouk Anhar Hamza Emmanuel Siddig Ahmed H Fahal |
author_facet |
Amre Nasr Amir Abushouk Anhar Hamza Emmanuel Siddig Ahmed H Fahal |
author_sort |
Amre Nasr |
title |
Th-1, Th-2 Cytokines Profile among Madurella mycetomatis Eumycetoma Patients. |
title_short |
Th-1, Th-2 Cytokines Profile among Madurella mycetomatis Eumycetoma Patients. |
title_full |
Th-1, Th-2 Cytokines Profile among Madurella mycetomatis Eumycetoma Patients. |
title_fullStr |
Th-1, Th-2 Cytokines Profile among Madurella mycetomatis Eumycetoma Patients. |
title_full_unstemmed |
Th-1, Th-2 Cytokines Profile among Madurella mycetomatis Eumycetoma Patients. |
title_sort |
th-1, th-2 cytokines profile among madurella mycetomatis eumycetoma patients. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2016 |
url |
https://doi.org/10.1371/journal.pntd.0004862 https://doaj.org/article/659afafacb8f4ef0b0d1fad372efbb21 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 10, Iss 7, p e0004862 (2016) |
op_relation |
http://europepmc.org/articles/PMC4951069?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0004862 https://doaj.org/article/659afafacb8f4ef0b0d1fad372efbb21 |
op_doi |
https://doi.org/10.1371/journal.pntd.0004862 |
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PLOS Neglected Tropical Diseases |
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7 |
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e0004862 |
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