Benign and malignant neoplasias in 261 necropsies for HIV-positive patients in the period of 1989 to 2008
Considering that there are some studies with autopsies from AIDS describing only malignant neoplasias and that changes can occur after the introduction of Highly Active Antiretroviral Therapy (HAART), our objectives were to analyze the frequency of benign and malignant neoplasms in AIDS patients in...
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ftdoajarticles:oai:doaj.org/article:6545853469774c0c9390d0fbfee82c53 2024-09-09T19:26:31+00:00 Benign and malignant neoplasias in 261 necropsies for HIV-positive patients in the period of 1989 to 2008 Adilha Rua Micheletti Ana Carolina Sandoval Macedo Gisele Barbosa e Silva Ana Cristina Araújo Lemos da Silva Mário Leon Silva-Vergara Eddie Fernando Cândido Murta Sheila Jorge Adad 2011-12-01T00:00:00Z https://doi.org/10.1590/S0036-46652011000600002 https://doaj.org/article/6545853469774c0c9390d0fbfee82c53 EN eng Universidade de São Paulo (USP) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652011000600002&lng=en&tlng=en https://doaj.org/toc/1678-9946 1678-9946 doi:10.1590/S0036-46652011000600002 https://doaj.org/article/6545853469774c0c9390d0fbfee82c53 Revista do Instituto de Medicina Tropical de São Paulo, Vol 53, Iss 6, Pp 309-314 (2011) HIV AIDS Neoplasm benign Neoplasm malignant Necropsy Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2011 ftdoajarticles https://doi.org/10.1590/S0036-46652011000600002 2024-08-05T17:49:30Z Considering that there are some studies with autopsies from AIDS describing only malignant neoplasias and that changes can occur after the introduction of Highly Active Antiretroviral Therapy (HAART), our objectives were to analyze the frequency of benign and malignant neoplasms in AIDS patients in the periods of both pre- and post-HAART. This is a retrospective study with 261 autopsies of HIV-positive patients between 1989 and 2008 in Uberaba, Brazil. Sixty-six neoplasms were found (39 benign, 21 malignant and six premalignant) in 58 patients. The most frequent malignant neoplasms were lymphoid, in 2.7% (four Non-Hodgkin lymphoma, one Hodgkin, one multiple myeloma and one plasmablastic plasmacytoma), and Kaposi's Sarcoma, in 2.3% (six cases). The most frequent benign neoplasms were hepatic hemangiomas in 11 (4.2%) of 261 cases and uterine leiomyoma in 11 (15.7%) of 70 woman. In the pre-HAART period eight (9.8%) benign neoplasias and four (4.9%) malignant occurred in 82 patients; in the post-HAART period, 29 (16.2%) benign and 17 (9.5%) malignant were present; however, the differences were not significant. We conclude that the introduction of HAART in our region doesn't look to have modified the frequency of neoplasms occurring in patients with HIV. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista do Instituto de Medicina Tropical de São Paulo 53 6 309 314 |
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HIV AIDS Neoplasm benign Neoplasm malignant Necropsy Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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HIV AIDS Neoplasm benign Neoplasm malignant Necropsy Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Adilha Rua Micheletti Ana Carolina Sandoval Macedo Gisele Barbosa e Silva Ana Cristina Araújo Lemos da Silva Mário Leon Silva-Vergara Eddie Fernando Cândido Murta Sheila Jorge Adad Benign and malignant neoplasias in 261 necropsies for HIV-positive patients in the period of 1989 to 2008 |
topic_facet |
HIV AIDS Neoplasm benign Neoplasm malignant Necropsy Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Considering that there are some studies with autopsies from AIDS describing only malignant neoplasias and that changes can occur after the introduction of Highly Active Antiretroviral Therapy (HAART), our objectives were to analyze the frequency of benign and malignant neoplasms in AIDS patients in the periods of both pre- and post-HAART. This is a retrospective study with 261 autopsies of HIV-positive patients between 1989 and 2008 in Uberaba, Brazil. Sixty-six neoplasms were found (39 benign, 21 malignant and six premalignant) in 58 patients. The most frequent malignant neoplasms were lymphoid, in 2.7% (four Non-Hodgkin lymphoma, one Hodgkin, one multiple myeloma and one plasmablastic plasmacytoma), and Kaposi's Sarcoma, in 2.3% (six cases). The most frequent benign neoplasms were hepatic hemangiomas in 11 (4.2%) of 261 cases and uterine leiomyoma in 11 (15.7%) of 70 woman. In the pre-HAART period eight (9.8%) benign neoplasias and four (4.9%) malignant occurred in 82 patients; in the post-HAART period, 29 (16.2%) benign and 17 (9.5%) malignant were present; however, the differences were not significant. We conclude that the introduction of HAART in our region doesn't look to have modified the frequency of neoplasms occurring in patients with HIV. |
format |
Article in Journal/Newspaper |
author |
Adilha Rua Micheletti Ana Carolina Sandoval Macedo Gisele Barbosa e Silva Ana Cristina Araújo Lemos da Silva Mário Leon Silva-Vergara Eddie Fernando Cândido Murta Sheila Jorge Adad |
author_facet |
Adilha Rua Micheletti Ana Carolina Sandoval Macedo Gisele Barbosa e Silva Ana Cristina Araújo Lemos da Silva Mário Leon Silva-Vergara Eddie Fernando Cândido Murta Sheila Jorge Adad |
author_sort |
Adilha Rua Micheletti |
title |
Benign and malignant neoplasias in 261 necropsies for HIV-positive patients in the period of 1989 to 2008 |
title_short |
Benign and malignant neoplasias in 261 necropsies for HIV-positive patients in the period of 1989 to 2008 |
title_full |
Benign and malignant neoplasias in 261 necropsies for HIV-positive patients in the period of 1989 to 2008 |
title_fullStr |
Benign and malignant neoplasias in 261 necropsies for HIV-positive patients in the period of 1989 to 2008 |
title_full_unstemmed |
Benign and malignant neoplasias in 261 necropsies for HIV-positive patients in the period of 1989 to 2008 |
title_sort |
benign and malignant neoplasias in 261 necropsies for hiv-positive patients in the period of 1989 to 2008 |
publisher |
Universidade de São Paulo (USP) |
publishDate |
2011 |
url |
https://doi.org/10.1590/S0036-46652011000600002 https://doaj.org/article/6545853469774c0c9390d0fbfee82c53 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista do Instituto de Medicina Tropical de São Paulo, Vol 53, Iss 6, Pp 309-314 (2011) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652011000600002&lng=en&tlng=en https://doaj.org/toc/1678-9946 1678-9946 doi:10.1590/S0036-46652011000600002 https://doaj.org/article/6545853469774c0c9390d0fbfee82c53 |
op_doi |
https://doi.org/10.1590/S0036-46652011000600002 |
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Revista do Instituto de Medicina Tropical de São Paulo |
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53 |
container_issue |
6 |
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309 |
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