Molecular characterization of rabies virus isolated from non-haematophagous bats in Brazil
INTRODUCTION: Rabies is an important zoonosis that causes thousands of deaths worldwide each year. Although the terrestrial cycle, mainly transmitted by dogs, is controlled in Brazil, the aerial cycle remains a serious public health issue, besides the economic problem. In the aerial cycle, the haema...
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ftdoajarticles:oai:doaj.org/article:64909f24ef6e42fc9f18d8a381c2e128 2023-05-15T15:08:40+02:00 Molecular characterization of rabies virus isolated from non-haematophagous bats in Brazil Avelino Albas Angélica Cristine de Almeida Campos Danielle Bastos Araujo Camila Seabra Rodrigues Miriam Martos Sodré Edison Luiz Durigon Silvana Regina Favoretto 2011-12-01T00:00:00Z https://doi.org/10.1590/S0037-86822011000600006 https://doaj.org/article/64909f24ef6e42fc9f18d8a381c2e128 EN eng Sociedade Brasileira de Medicina Tropical (SBMT) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822011000600006&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/S0037-86822011000600006 https://doaj.org/article/64909f24ef6e42fc9f18d8a381c2e128 Revista da Sociedade Brasileira de Medicina Tropical, Vol 44, Iss 6, Pp 678-683 (2011) Raiva Morcegos Caracterização antigênica Caracterização genética Arctic medicine. Tropical medicine RC955-962 article 2011 ftdoajarticles https://doi.org/10.1590/S0037-86822011000600006 2022-12-30T23:23:59Z INTRODUCTION: Rabies is an important zoonosis that causes thousands of deaths worldwide each year. Although the terrestrial cycle, mainly transmitted by dogs, is controlled in Brazil, the aerial cycle remains a serious public health issue, besides the economic problem. In the aerial cycle, the haematophagous bat Desmodus rotundus is the main source of infection, where several different species of non-haematophagous bats can be infected and can transmit the virus. METHODS: The aim of this work was to study the epidemiological pattern of rabies using antigenic characterization with monoclonal antibodies and genetic characterization by reverse-transcriptase polymerase chain reaction followed by sequencing and phylogenetic analysis of non-haematophagous bats' and herbivorous animals' central nervous system samples from the western region of the State of São Paulo, Brazil. RESULTS: From 27 samples, 3 antigenic variants were identified: AgV-3, AgV-4, and AgV-6; and from 29 samples, 5 different clusters were identified, all belonging to the rabies virus species. CONCLUSIONS: Although only non-haematophagous bats were evaluated in the studied region, the majority of samples were from antigenic and genetic variants related to haematophagous bats Desmodus rotundus. Samples from the same antigenic variant were segregated in more than one genetic cluster. This study demonstrated the diversity of rabies virus genetic lineages presented and circulating in non-haematophagous bats in the studied region. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista da Sociedade Brasileira de Medicina Tropical 44 6 678 683 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
topic |
Raiva Morcegos Caracterização antigênica Caracterização genética Arctic medicine. Tropical medicine RC955-962 |
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Raiva Morcegos Caracterização antigênica Caracterização genética Arctic medicine. Tropical medicine RC955-962 Avelino Albas Angélica Cristine de Almeida Campos Danielle Bastos Araujo Camila Seabra Rodrigues Miriam Martos Sodré Edison Luiz Durigon Silvana Regina Favoretto Molecular characterization of rabies virus isolated from non-haematophagous bats in Brazil |
topic_facet |
Raiva Morcegos Caracterização antigênica Caracterização genética Arctic medicine. Tropical medicine RC955-962 |
description |
INTRODUCTION: Rabies is an important zoonosis that causes thousands of deaths worldwide each year. Although the terrestrial cycle, mainly transmitted by dogs, is controlled in Brazil, the aerial cycle remains a serious public health issue, besides the economic problem. In the aerial cycle, the haematophagous bat Desmodus rotundus is the main source of infection, where several different species of non-haematophagous bats can be infected and can transmit the virus. METHODS: The aim of this work was to study the epidemiological pattern of rabies using antigenic characterization with monoclonal antibodies and genetic characterization by reverse-transcriptase polymerase chain reaction followed by sequencing and phylogenetic analysis of non-haematophagous bats' and herbivorous animals' central nervous system samples from the western region of the State of São Paulo, Brazil. RESULTS: From 27 samples, 3 antigenic variants were identified: AgV-3, AgV-4, and AgV-6; and from 29 samples, 5 different clusters were identified, all belonging to the rabies virus species. CONCLUSIONS: Although only non-haematophagous bats were evaluated in the studied region, the majority of samples were from antigenic and genetic variants related to haematophagous bats Desmodus rotundus. Samples from the same antigenic variant were segregated in more than one genetic cluster. This study demonstrated the diversity of rabies virus genetic lineages presented and circulating in non-haematophagous bats in the studied region. |
format |
Article in Journal/Newspaper |
author |
Avelino Albas Angélica Cristine de Almeida Campos Danielle Bastos Araujo Camila Seabra Rodrigues Miriam Martos Sodré Edison Luiz Durigon Silvana Regina Favoretto |
author_facet |
Avelino Albas Angélica Cristine de Almeida Campos Danielle Bastos Araujo Camila Seabra Rodrigues Miriam Martos Sodré Edison Luiz Durigon Silvana Regina Favoretto |
author_sort |
Avelino Albas |
title |
Molecular characterization of rabies virus isolated from non-haematophagous bats in Brazil |
title_short |
Molecular characterization of rabies virus isolated from non-haematophagous bats in Brazil |
title_full |
Molecular characterization of rabies virus isolated from non-haematophagous bats in Brazil |
title_fullStr |
Molecular characterization of rabies virus isolated from non-haematophagous bats in Brazil |
title_full_unstemmed |
Molecular characterization of rabies virus isolated from non-haematophagous bats in Brazil |
title_sort |
molecular characterization of rabies virus isolated from non-haematophagous bats in brazil |
publisher |
Sociedade Brasileira de Medicina Tropical (SBMT) |
publishDate |
2011 |
url |
https://doi.org/10.1590/S0037-86822011000600006 https://doaj.org/article/64909f24ef6e42fc9f18d8a381c2e128 |
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Arctic |
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Arctic |
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Arctic |
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Arctic |
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Revista da Sociedade Brasileira de Medicina Tropical, Vol 44, Iss 6, Pp 678-683 (2011) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822011000600006&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/S0037-86822011000600006 https://doaj.org/article/64909f24ef6e42fc9f18d8a381c2e128 |
op_doi |
https://doi.org/10.1590/S0037-86822011000600006 |
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Revista da Sociedade Brasileira de Medicina Tropical |
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44 |
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