Doses of chloroquine in the treatment of malaria by Plasmodium vivax in patients between 2 and 14 years of age from the Brazilian Amazon basin
Abstract Background A total dose of chloroquine of 25 mg/kg is recommended by the World Health Organization (WHO) to treat malaria by Plasmodium vivax. In several endemic areas, including the Brazilian Amazon basin, anti-malarial drugs are dispensed in small plastic bags at a dosing regimen based on...
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ftdoajarticles:oai:doaj.org/article:648e6c74c53f438fbba32c83acd37c98 2023-05-15T15:17:47+02:00 Doses of chloroquine in the treatment of malaria by Plasmodium vivax in patients between 2 and 14 years of age from the Brazilian Amazon basin Luann Wendel Pereira de Sena Amanda Gabryelle Nunes Cardoso Mello Michelle Valéria Dias Ferreira Marcieni Andrade de Ataide Rosa Maria Dias José Luiz Fernandes Vieira 2019-12-01T00:00:00Z https://doi.org/10.1186/s12936-019-3072-8 https://doaj.org/article/648e6c74c53f438fbba32c83acd37c98 EN eng BMC https://doi.org/10.1186/s12936-019-3072-8 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-019-3072-8 1475-2875 https://doaj.org/article/648e6c74c53f438fbba32c83acd37c98 Malaria Journal, Vol 18, Iss 1, Pp 1-7 (2019) Malaria Chloroquine Pharmacokinetics Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2019 ftdoajarticles https://doi.org/10.1186/s12936-019-3072-8 2022-12-31T06:13:36Z Abstract Background A total dose of chloroquine of 25 mg/kg is recommended by the World Health Organization (WHO) to treat malaria by Plasmodium vivax. In several endemic areas, including the Brazilian Amazon basin, anti-malarial drugs are dispensed in small plastic bags at a dosing regimen based on age. This practice can lead to suboptimal dosing of the drug, which can impact treatment outcomes. The aim of the present study was to estimate the extent of sub-dosing of chloroquine in children and adolescents with vivax malaria using an age-based dose regimen, in addition to investigating the influence of age on the plasma concentrations of chloroquine and desethylchloroquine. Methods A study of cases was conducted with male patients with a confirmed infection by P. vivax, ages 2 to 14 years, using a combined regimen of chloroquine and primaquine. Height, weight and body surface area were determined at admission on the study. The total dose of chloroquine administered was estimated based on the weight and on the body surface area of the study patients. Chloroquine and desethylchloroquine were measured on Day 7 in each patient included in the study by a high-performance liquid chromatographic method with fluorescence detection. Results A total of 81 patients were enrolled and completed the study. The median age was 9 years (2–14 years). All patients presented negative blood smears at 42 days follow-up. The total dose of chloroquine ranged from 13.1 to 38.1 mg/kg. The percentage of patients with a total dose of the drug below 25 mg/kg ranged from 29.4 to 63.6%. The total dose of chloroquine administered based on BSA ranged from 387 to 1079 mg/m2, increasing with age. Plasma chloroquine concentrations ranged from 107 to 420 ng/ml, increasing with age. For desethylchloroquine, the plasma concentrations ranged from 167 to 390 ng/ml, with similar values among age-groups. Conclusion The data demonstrated the widespread exposure of children and adolescents to suboptimal doses of chloroquine in the endemic area ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 18 1 |
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English |
topic |
Malaria Chloroquine Pharmacokinetics Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Malaria Chloroquine Pharmacokinetics Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Luann Wendel Pereira de Sena Amanda Gabryelle Nunes Cardoso Mello Michelle Valéria Dias Ferreira Marcieni Andrade de Ataide Rosa Maria Dias José Luiz Fernandes Vieira Doses of chloroquine in the treatment of malaria by Plasmodium vivax in patients between 2 and 14 years of age from the Brazilian Amazon basin |
topic_facet |
Malaria Chloroquine Pharmacokinetics Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background A total dose of chloroquine of 25 mg/kg is recommended by the World Health Organization (WHO) to treat malaria by Plasmodium vivax. In several endemic areas, including the Brazilian Amazon basin, anti-malarial drugs are dispensed in small plastic bags at a dosing regimen based on age. This practice can lead to suboptimal dosing of the drug, which can impact treatment outcomes. The aim of the present study was to estimate the extent of sub-dosing of chloroquine in children and adolescents with vivax malaria using an age-based dose regimen, in addition to investigating the influence of age on the plasma concentrations of chloroquine and desethylchloroquine. Methods A study of cases was conducted with male patients with a confirmed infection by P. vivax, ages 2 to 14 years, using a combined regimen of chloroquine and primaquine. Height, weight and body surface area were determined at admission on the study. The total dose of chloroquine administered was estimated based on the weight and on the body surface area of the study patients. Chloroquine and desethylchloroquine were measured on Day 7 in each patient included in the study by a high-performance liquid chromatographic method with fluorescence detection. Results A total of 81 patients were enrolled and completed the study. The median age was 9 years (2–14 years). All patients presented negative blood smears at 42 days follow-up. The total dose of chloroquine ranged from 13.1 to 38.1 mg/kg. The percentage of patients with a total dose of the drug below 25 mg/kg ranged from 29.4 to 63.6%. The total dose of chloroquine administered based on BSA ranged from 387 to 1079 mg/m2, increasing with age. Plasma chloroquine concentrations ranged from 107 to 420 ng/ml, increasing with age. For desethylchloroquine, the plasma concentrations ranged from 167 to 390 ng/ml, with similar values among age-groups. Conclusion The data demonstrated the widespread exposure of children and adolescents to suboptimal doses of chloroquine in the endemic area ... |
format |
Article in Journal/Newspaper |
author |
Luann Wendel Pereira de Sena Amanda Gabryelle Nunes Cardoso Mello Michelle Valéria Dias Ferreira Marcieni Andrade de Ataide Rosa Maria Dias José Luiz Fernandes Vieira |
author_facet |
Luann Wendel Pereira de Sena Amanda Gabryelle Nunes Cardoso Mello Michelle Valéria Dias Ferreira Marcieni Andrade de Ataide Rosa Maria Dias José Luiz Fernandes Vieira |
author_sort |
Luann Wendel Pereira de Sena |
title |
Doses of chloroquine in the treatment of malaria by Plasmodium vivax in patients between 2 and 14 years of age from the Brazilian Amazon basin |
title_short |
Doses of chloroquine in the treatment of malaria by Plasmodium vivax in patients between 2 and 14 years of age from the Brazilian Amazon basin |
title_full |
Doses of chloroquine in the treatment of malaria by Plasmodium vivax in patients between 2 and 14 years of age from the Brazilian Amazon basin |
title_fullStr |
Doses of chloroquine in the treatment of malaria by Plasmodium vivax in patients between 2 and 14 years of age from the Brazilian Amazon basin |
title_full_unstemmed |
Doses of chloroquine in the treatment of malaria by Plasmodium vivax in patients between 2 and 14 years of age from the Brazilian Amazon basin |
title_sort |
doses of chloroquine in the treatment of malaria by plasmodium vivax in patients between 2 and 14 years of age from the brazilian amazon basin |
publisher |
BMC |
publishDate |
2019 |
url |
https://doi.org/10.1186/s12936-019-3072-8 https://doaj.org/article/648e6c74c53f438fbba32c83acd37c98 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 18, Iss 1, Pp 1-7 (2019) |
op_relation |
https://doi.org/10.1186/s12936-019-3072-8 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-019-3072-8 1475-2875 https://doaj.org/article/648e6c74c53f438fbba32c83acd37c98 |
op_doi |
https://doi.org/10.1186/s12936-019-3072-8 |
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Malaria Journal |
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18 |
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1 |
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1766348023331291136 |