Natural history of experimental arthritis induced by Paracoccidioides brasiliensis in wistar rats

• Published in: Revista da Sociedade Brasileira de Medicina Tropical
• Main Authors: Eduardo Alexandre Loth, Vanessa Cecatto, Rodrigo Daniel Genske, Maricília Silva Costa, Rinaldo Ferreira Gandra, Cleverson Marcelo Pilatti
• Format: Article in Journal/Newspaper
• Language: English
• Published: Sociedade Brasileira de Medicina Tropical (SBMT) 2019
• Subjects: Arthritis; Paracoccidioidomycosis; Paracoccidioides brasiliensis; Arctic medicine. Tropical medicine; RC955-962; Arctic
• Online Access: https://doi.org/10.1590/0037-8682-0043-2018; https://doaj.org/article/63faf8521081424dbb00ff8264685254

Abstract INTRODUCTION: Paracoccidioidomycosis (PCM) is the most prevalent systemic mycosis in Latin America. This study aimed to evaluate the natural history of Paracoccidioides brasiliensis-induced experimental arthritis of the knee joints in Wistar rats. METHODS: Rats were randomly allocated to either an absolute control group, or 15-day, 45-day, or 90-day experimental (fungus-inoculated) groups. RESULTS: Experimental groups developed classic signs of articular PCM. Titers of anti-gp43 were observed to increase during the interval from 15 to 45 days post-inoculation. CONCLUSIONS: Articular arthritic lesions were induced and progressed during the study period in all experimental groups.