The vgll3 Locus Controls Age at Maturity in Wild and Domesticated Atlantic Salmon (Salmo salar L.) Males.
Wild and domesticated Atlantic salmon males display large variation for sea age at sexual maturation, which varies between 1-5 years. Previous studies have uncovered a genetic predisposition for variation of age at maturity with moderate heritability, thus suggesting a polygenic or complex nature of...
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ftdoajarticles:oai:doaj.org/article:63da51e95bfb4fa183acc9fc25efef78 2023-05-15T15:31:45+02:00 The vgll3 Locus Controls Age at Maturity in Wild and Domesticated Atlantic Salmon (Salmo salar L.) Males. Fernando Ayllon Erik Kjærner-Semb Tomasz Furmanek Vidar Wennevik Monica F Solberg Geir Dahle Geir Lasse Taranger Kevin A Glover Markus Sällman Almén Carl J Rubin Rolf B Edvardsen Anna Wargelius 2015-11-01T00:00:00Z https://doi.org/10.1371/journal.pgen.1005628 https://doaj.org/article/63da51e95bfb4fa183acc9fc25efef78 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC4638356?pdf=render https://doaj.org/toc/1553-7390 https://doaj.org/toc/1553-7404 1553-7390 1553-7404 doi:10.1371/journal.pgen.1005628 https://doaj.org/article/63da51e95bfb4fa183acc9fc25efef78 PLoS Genetics, Vol 11, Iss 11, p e1005628 (2015) Genetics QH426-470 article 2015 ftdoajarticles https://doi.org/10.1371/journal.pgen.1005628 2022-12-31T12:48:00Z Wild and domesticated Atlantic salmon males display large variation for sea age at sexual maturation, which varies between 1-5 years. Previous studies have uncovered a genetic predisposition for variation of age at maturity with moderate heritability, thus suggesting a polygenic or complex nature of this trait. The aim of this study was to identify associated genetic loci, genes and ultimately specific sequence variants conferring sea age at maturity in salmon. We performed a genome wide association study (GWAS) using a pool sequencing approach (20 individuals per river and phenotype) of male salmon returning to rivers as sexually mature either after one sea winter (2009) or three sea winters (2011) in six rivers in Norway. The study revealed one major selective sweep, which covered 76 significant SNPs in which 74 were found in a 370 kb region of chromosome 25. Genotyping other smolt year classes of wild and domesticated salmon confirmed this finding. Genotyping domesticated fish narrowed the haplotype region to four SNPs covering 2386 bp, containing the vgll3 gene, including two missense mutations explaining 33-36% phenotypic variation. A single locus was found to have a highly significant role in governing sea age at maturation in this species. The SNPs identified may be both used as markers to guide breeding for late maturity in salmon aquaculture and in monitoring programs of wild salmon. Interestingly, a SNP in proximity of the VGLL3 gene in humans (Homo sapiens), has previously been linked to age at puberty suggesting a conserved mechanism for timing of puberty in vertebrates. Article in Journal/Newspaper Atlantic salmon Salmo salar Directory of Open Access Journals: DOAJ Articles Norway PLOS Genetics 11 11 e1005628 |
institution |
Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Genetics QH426-470 |
spellingShingle |
Genetics QH426-470 Fernando Ayllon Erik Kjærner-Semb Tomasz Furmanek Vidar Wennevik Monica F Solberg Geir Dahle Geir Lasse Taranger Kevin A Glover Markus Sällman Almén Carl J Rubin Rolf B Edvardsen Anna Wargelius The vgll3 Locus Controls Age at Maturity in Wild and Domesticated Atlantic Salmon (Salmo salar L.) Males. |
topic_facet |
Genetics QH426-470 |
description |
Wild and domesticated Atlantic salmon males display large variation for sea age at sexual maturation, which varies between 1-5 years. Previous studies have uncovered a genetic predisposition for variation of age at maturity with moderate heritability, thus suggesting a polygenic or complex nature of this trait. The aim of this study was to identify associated genetic loci, genes and ultimately specific sequence variants conferring sea age at maturity in salmon. We performed a genome wide association study (GWAS) using a pool sequencing approach (20 individuals per river and phenotype) of male salmon returning to rivers as sexually mature either after one sea winter (2009) or three sea winters (2011) in six rivers in Norway. The study revealed one major selective sweep, which covered 76 significant SNPs in which 74 were found in a 370 kb region of chromosome 25. Genotyping other smolt year classes of wild and domesticated salmon confirmed this finding. Genotyping domesticated fish narrowed the haplotype region to four SNPs covering 2386 bp, containing the vgll3 gene, including two missense mutations explaining 33-36% phenotypic variation. A single locus was found to have a highly significant role in governing sea age at maturation in this species. The SNPs identified may be both used as markers to guide breeding for late maturity in salmon aquaculture and in monitoring programs of wild salmon. Interestingly, a SNP in proximity of the VGLL3 gene in humans (Homo sapiens), has previously been linked to age at puberty suggesting a conserved mechanism for timing of puberty in vertebrates. |
format |
Article in Journal/Newspaper |
author |
Fernando Ayllon Erik Kjærner-Semb Tomasz Furmanek Vidar Wennevik Monica F Solberg Geir Dahle Geir Lasse Taranger Kevin A Glover Markus Sällman Almén Carl J Rubin Rolf B Edvardsen Anna Wargelius |
author_facet |
Fernando Ayllon Erik Kjærner-Semb Tomasz Furmanek Vidar Wennevik Monica F Solberg Geir Dahle Geir Lasse Taranger Kevin A Glover Markus Sällman Almén Carl J Rubin Rolf B Edvardsen Anna Wargelius |
author_sort |
Fernando Ayllon |
title |
The vgll3 Locus Controls Age at Maturity in Wild and Domesticated Atlantic Salmon (Salmo salar L.) Males. |
title_short |
The vgll3 Locus Controls Age at Maturity in Wild and Domesticated Atlantic Salmon (Salmo salar L.) Males. |
title_full |
The vgll3 Locus Controls Age at Maturity in Wild and Domesticated Atlantic Salmon (Salmo salar L.) Males. |
title_fullStr |
The vgll3 Locus Controls Age at Maturity in Wild and Domesticated Atlantic Salmon (Salmo salar L.) Males. |
title_full_unstemmed |
The vgll3 Locus Controls Age at Maturity in Wild and Domesticated Atlantic Salmon (Salmo salar L.) Males. |
title_sort |
vgll3 locus controls age at maturity in wild and domesticated atlantic salmon (salmo salar l.) males. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2015 |
url |
https://doi.org/10.1371/journal.pgen.1005628 https://doaj.org/article/63da51e95bfb4fa183acc9fc25efef78 |
geographic |
Norway |
geographic_facet |
Norway |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_source |
PLoS Genetics, Vol 11, Iss 11, p e1005628 (2015) |
op_relation |
http://europepmc.org/articles/PMC4638356?pdf=render https://doaj.org/toc/1553-7390 https://doaj.org/toc/1553-7404 1553-7390 1553-7404 doi:10.1371/journal.pgen.1005628 https://doaj.org/article/63da51e95bfb4fa183acc9fc25efef78 |
op_doi |
https://doi.org/10.1371/journal.pgen.1005628 |
container_title |
PLOS Genetics |
container_volume |
11 |
container_issue |
11 |
container_start_page |
e1005628 |
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1766362276235837440 |