Malaria incidence and efficacy of intermittent preventive treatment in infants (IPTi)
Abstract Background Intermittent preventive antimalarial treatment in infants (IPTi) is currently evaluated as a malaria control strategy. Among the factors influencing the extent of protection that is provided by IPTi are the transmission intensity, seasonality, drug resistance patterns, and the sc...
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ftdoajarticles:oai:doaj.org/article:639f2dee3b3b40758886a9160a8e5537 2023-05-15T15:16:42+02:00 Malaria incidence and efficacy of intermittent preventive treatment in infants (IPTi) Schreiber Nadine Tosun Meral Busch Wibke Marks Florian Thompson Peter A Thompson Benedicta Kreuels Benno Kreuzberg Christina Adjei Samuel Kobbe Robin Opoku Ernest Adjei Ohene Meyer Christian G May Juergen 2007-12-01T00:00:00Z https://doi.org/10.1186/1475-2875-6-163 https://doaj.org/article/639f2dee3b3b40758886a9160a8e5537 EN eng BMC http://www.malariajournal.com/content/6/1/163 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-6-163 1475-2875 https://doaj.org/article/639f2dee3b3b40758886a9160a8e5537 Malaria Journal, Vol 6, Iss 1, p 163 (2007) Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2007 ftdoajarticles https://doi.org/10.1186/1475-2875-6-163 2022-12-31T08:33:56Z Abstract Background Intermittent preventive antimalarial treatment in infants (IPTi) is currently evaluated as a malaria control strategy. Among the factors influencing the extent of protection that is provided by IPTi are the transmission intensity, seasonality, drug resistance patterns, and the schedule of IPTi administrations. The aim of this study was to determine how far the protective efficacy of IPTi depends on spatio-temporal variations of the prevailing incidence of malaria. Methods One thousand seventy infants were enrolled in a registered controlled trial on the efficacy of IPTi with sulphadoxine-pyrimethamine (SP) in the Ashanti Region, Ghana, West Africa (ClinicalTrial.gov: NCT00206739). Stratification for the village of residence and the month of birth of study participants demonstrated that the malaria incidence was dependent on spatial (range of incidence rates in different villages 0.6–2.0 episodes/year) and temporal (range of incidence rates in children of different birth months 0.8–1.2 episodes/year) factors. The range of spatio-temporal variation allowed ecological analyses of the correlation between malaria incidence rates, anti- Plasmodium falciparum lysate IgG antibody levels and protective efficacies provided by IPTi. Results Protective efficacy of the first SP administration was positively correlated with malaria incidences in children living in a distinct village or born in a distinct month (R 2 0.48, p < 0.04 and R 2 0.63, p < 0.003, respectively). Corresponding trends were seen after the second and third study drug administration. Accordingly, IgG levels against parasite lysate increased with malaria incidence. This correlation was stronger in children who received IPTi, indicating an effect modification of the intervention. Conclusion The spatial and temporal variations of malaria incidences in a geographically and meteorologically homogeneous study area exemplify the need for close monitoring of local incidence rates in all types of intervention studies. The increase of the ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 6 1 163 |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Schreiber Nadine Tosun Meral Busch Wibke Marks Florian Thompson Peter A Thompson Benedicta Kreuels Benno Kreuzberg Christina Adjei Samuel Kobbe Robin Opoku Ernest Adjei Ohene Meyer Christian G May Juergen Malaria incidence and efficacy of intermittent preventive treatment in infants (IPTi) |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Intermittent preventive antimalarial treatment in infants (IPTi) is currently evaluated as a malaria control strategy. Among the factors influencing the extent of protection that is provided by IPTi are the transmission intensity, seasonality, drug resistance patterns, and the schedule of IPTi administrations. The aim of this study was to determine how far the protective efficacy of IPTi depends on spatio-temporal variations of the prevailing incidence of malaria. Methods One thousand seventy infants were enrolled in a registered controlled trial on the efficacy of IPTi with sulphadoxine-pyrimethamine (SP) in the Ashanti Region, Ghana, West Africa (ClinicalTrial.gov: NCT00206739). Stratification for the village of residence and the month of birth of study participants demonstrated that the malaria incidence was dependent on spatial (range of incidence rates in different villages 0.6–2.0 episodes/year) and temporal (range of incidence rates in children of different birth months 0.8–1.2 episodes/year) factors. The range of spatio-temporal variation allowed ecological analyses of the correlation between malaria incidence rates, anti- Plasmodium falciparum lysate IgG antibody levels and protective efficacies provided by IPTi. Results Protective efficacy of the first SP administration was positively correlated with malaria incidences in children living in a distinct village or born in a distinct month (R 2 0.48, p < 0.04 and R 2 0.63, p < 0.003, respectively). Corresponding trends were seen after the second and third study drug administration. Accordingly, IgG levels against parasite lysate increased with malaria incidence. This correlation was stronger in children who received IPTi, indicating an effect modification of the intervention. Conclusion The spatial and temporal variations of malaria incidences in a geographically and meteorologically homogeneous study area exemplify the need for close monitoring of local incidence rates in all types of intervention studies. The increase of the ... |
format |
Article in Journal/Newspaper |
author |
Schreiber Nadine Tosun Meral Busch Wibke Marks Florian Thompson Peter A Thompson Benedicta Kreuels Benno Kreuzberg Christina Adjei Samuel Kobbe Robin Opoku Ernest Adjei Ohene Meyer Christian G May Juergen |
author_facet |
Schreiber Nadine Tosun Meral Busch Wibke Marks Florian Thompson Peter A Thompson Benedicta Kreuels Benno Kreuzberg Christina Adjei Samuel Kobbe Robin Opoku Ernest Adjei Ohene Meyer Christian G May Juergen |
author_sort |
Schreiber Nadine |
title |
Malaria incidence and efficacy of intermittent preventive treatment in infants (IPTi) |
title_short |
Malaria incidence and efficacy of intermittent preventive treatment in infants (IPTi) |
title_full |
Malaria incidence and efficacy of intermittent preventive treatment in infants (IPTi) |
title_fullStr |
Malaria incidence and efficacy of intermittent preventive treatment in infants (IPTi) |
title_full_unstemmed |
Malaria incidence and efficacy of intermittent preventive treatment in infants (IPTi) |
title_sort |
malaria incidence and efficacy of intermittent preventive treatment in infants (ipti) |
publisher |
BMC |
publishDate |
2007 |
url |
https://doi.org/10.1186/1475-2875-6-163 https://doaj.org/article/639f2dee3b3b40758886a9160a8e5537 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 6, Iss 1, p 163 (2007) |
op_relation |
http://www.malariajournal.com/content/6/1/163 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-6-163 1475-2875 https://doaj.org/article/639f2dee3b3b40758886a9160a8e5537 |
op_doi |
https://doi.org/10.1186/1475-2875-6-163 |
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Malaria Journal |
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6 |
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1 |
container_start_page |
163 |
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1766346990350761984 |