Prevalence and clinical outcomes of episodes of ventilator-associated pneumonia caused by SPM-1-producing and non-producing imipenem-resistant Pseudomonas aeruginosa
INTRODUCTION: Pseudomonas aeruginosa is a leading cause of ventilator-associated pneumonia (VAP) and exhibits high rates of resistance to several antimicrobial drugs. The carbapenens are usually the drugs of choice against this microorganism. However, the carbapenem resistance has increased among th...
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ftdoajarticles:oai:doaj.org/article:62ddf7a502644466ab514fc449e73d65 2023-05-15T15:07:45+02:00 Prevalence and clinical outcomes of episodes of ventilator-associated pneumonia caused by SPM-1-producing and non-producing imipenem-resistant Pseudomonas aeruginosa Guilherme Henrique Campos Furtado Ana Cristina Gales Luciana Baria Perdiz Anderson Fernandes Santos Eduardo Alexandrino Servolo de Medeiros 2011-10-01T00:00:00Z https://doi.org/10.1590/S0037-86822011000500015 https://doaj.org/article/62ddf7a502644466ab514fc449e73d65 EN eng Sociedade Brasileira de Medicina Tropical (SBMT) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822011000500015&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/S0037-86822011000500015 https://doaj.org/article/62ddf7a502644466ab514fc449e73d65 Revista da Sociedade Brasileira de Medicina Tropical, Vol 44, Iss 5, Pp 604-606 (2011) Pseudomonas aeruginosa Resistência antimicrobiana Desfecho Arctic medicine. Tropical medicine RC955-962 article 2011 ftdoajarticles https://doi.org/10.1590/S0037-86822011000500015 2022-12-30T23:22:39Z INTRODUCTION: Pseudomonas aeruginosa is a leading cause of ventilator-associated pneumonia (VAP) and exhibits high rates of resistance to several antimicrobial drugs. The carbapenens are usually the drugs of choice against this microorganism. However, the carbapenem resistance has increased among these strains worldwide. The presence of metallo-β-lactamases (MBL) has been pointed out as a major mechanism of resistance among these strains. No previous study addressed outcomes of respiratory infections caused by these strains. METHODS: Our group sought to analyze the epidemiology and clinical outcomes of patients with VAP caused by imipenem-resistant P. aeruginosa. A total of 29 clinical isolates of carbapenem-resistant Pseudomonas aeruginosa were screened for metallo-β-lactamase (MBL) genes. RESULTS: Demographic and clinical variables were similar between the SPM-1-producing and non-SPM-1-producing group. Five (17.2%) isolates were positive for blaSPM-1. No other MBL gene was found. All patients were treated with polymyxin B. The infection-related mortality was 40% and 54.2% for SPM-1-producing and -non-producing isolates, respectively. CONCLUSIONS: There were no differences in epidemiological and clinical outcomes between the two groups. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista da Sociedade Brasileira de Medicina Tropical 44 5 604 606 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Pseudomonas aeruginosa Resistência antimicrobiana Desfecho Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Pseudomonas aeruginosa Resistência antimicrobiana Desfecho Arctic medicine. Tropical medicine RC955-962 Guilherme Henrique Campos Furtado Ana Cristina Gales Luciana Baria Perdiz Anderson Fernandes Santos Eduardo Alexandrino Servolo de Medeiros Prevalence and clinical outcomes of episodes of ventilator-associated pneumonia caused by SPM-1-producing and non-producing imipenem-resistant Pseudomonas aeruginosa |
topic_facet |
Pseudomonas aeruginosa Resistência antimicrobiana Desfecho Arctic medicine. Tropical medicine RC955-962 |
description |
INTRODUCTION: Pseudomonas aeruginosa is a leading cause of ventilator-associated pneumonia (VAP) and exhibits high rates of resistance to several antimicrobial drugs. The carbapenens are usually the drugs of choice against this microorganism. However, the carbapenem resistance has increased among these strains worldwide. The presence of metallo-β-lactamases (MBL) has been pointed out as a major mechanism of resistance among these strains. No previous study addressed outcomes of respiratory infections caused by these strains. METHODS: Our group sought to analyze the epidemiology and clinical outcomes of patients with VAP caused by imipenem-resistant P. aeruginosa. A total of 29 clinical isolates of carbapenem-resistant Pseudomonas aeruginosa were screened for metallo-β-lactamase (MBL) genes. RESULTS: Demographic and clinical variables were similar between the SPM-1-producing and non-SPM-1-producing group. Five (17.2%) isolates were positive for blaSPM-1. No other MBL gene was found. All patients were treated with polymyxin B. The infection-related mortality was 40% and 54.2% for SPM-1-producing and -non-producing isolates, respectively. CONCLUSIONS: There were no differences in epidemiological and clinical outcomes between the two groups. |
format |
Article in Journal/Newspaper |
author |
Guilherme Henrique Campos Furtado Ana Cristina Gales Luciana Baria Perdiz Anderson Fernandes Santos Eduardo Alexandrino Servolo de Medeiros |
author_facet |
Guilherme Henrique Campos Furtado Ana Cristina Gales Luciana Baria Perdiz Anderson Fernandes Santos Eduardo Alexandrino Servolo de Medeiros |
author_sort |
Guilherme Henrique Campos Furtado |
title |
Prevalence and clinical outcomes of episodes of ventilator-associated pneumonia caused by SPM-1-producing and non-producing imipenem-resistant Pseudomonas aeruginosa |
title_short |
Prevalence and clinical outcomes of episodes of ventilator-associated pneumonia caused by SPM-1-producing and non-producing imipenem-resistant Pseudomonas aeruginosa |
title_full |
Prevalence and clinical outcomes of episodes of ventilator-associated pneumonia caused by SPM-1-producing and non-producing imipenem-resistant Pseudomonas aeruginosa |
title_fullStr |
Prevalence and clinical outcomes of episodes of ventilator-associated pneumonia caused by SPM-1-producing and non-producing imipenem-resistant Pseudomonas aeruginosa |
title_full_unstemmed |
Prevalence and clinical outcomes of episodes of ventilator-associated pneumonia caused by SPM-1-producing and non-producing imipenem-resistant Pseudomonas aeruginosa |
title_sort |
prevalence and clinical outcomes of episodes of ventilator-associated pneumonia caused by spm-1-producing and non-producing imipenem-resistant pseudomonas aeruginosa |
publisher |
Sociedade Brasileira de Medicina Tropical (SBMT) |
publishDate |
2011 |
url |
https://doi.org/10.1590/S0037-86822011000500015 https://doaj.org/article/62ddf7a502644466ab514fc449e73d65 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista da Sociedade Brasileira de Medicina Tropical, Vol 44, Iss 5, Pp 604-606 (2011) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822011000500015&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/S0037-86822011000500015 https://doaj.org/article/62ddf7a502644466ab514fc449e73d65 |
op_doi |
https://doi.org/10.1590/S0037-86822011000500015 |
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Revista da Sociedade Brasileira de Medicina Tropical |
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44 |
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604 |
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