Genetic Polymorphisms of 30 InDel Loci in Ewenki Ethnic Group from Inner Mongolia
Objective To study the genetic polymorphisms of 30 insertion/deletion (InDel) loci and evaluate their forensic application in Ewenki ethnic group from Inner Mongolia. Methods Peripheral blood samples were collected from 87 unrelated healthy individuals in Ewenki ethnic group. Genomic DNA were extrac...
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Editorial Office of Journal of Forensic Medicine
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ftdoajarticles:oai:doaj.org/article:62b81c5e0fb34a2eaf3d2aefc35c6e28 2024-09-15T18:05:20+00:00 Genetic Polymorphisms of 30 InDel Loci in Ewenki Ethnic Group from Inner Mongolia JIN XIAO-YE WEI YUAN-YUAN HE YONG-FENG 2017-06-01T00:00:00Z https://doi.org/10.3969/j.issn.1004-5619.2017.03.012 https://doaj.org/article/62b81c5e0fb34a2eaf3d2aefc35c6e28 ZH chi Editorial Office of Journal of Forensic Medicine http://www.fyxzz.cn/fileup/1004-5619/PDF/FYXZZ201703012.pdf https://doaj.org/toc/1004-5619 1004-5619 doi:10.3969/j.issn.1004-5619.2017.03.012 https://doaj.org/article/62b81c5e0fb34a2eaf3d2aefc35c6e28 Fayixue Zazhi, Vol 33, Iss 3, Pp 271-276 (2017) forensic genetics polymorphism,genetic insertion/deletion ewenki ethnic group inner mongolia Medicine R article 2017 ftdoajarticles https://doi.org/10.3969/j.issn.1004-5619.2017.03.012 2024-09-02T15:34:39Z Objective To study the genetic polymorphisms of 30 insertion/deletion (InDel) loci and evaluate their forensic application in Ewenki ethnic group from Inner Mongolia. Methods Peripheral blood samples were collected from 87 unrelated healthy individuals in Ewenki ethnic group. Genomic DNA were extracted, and 30 InDel loci of the samples were multiplex amplified and genotyped. Hardy-Weinberg balance tests were preformed for all loci and genetic parameters were calculated by modified PowerStats v1.2 software. The linkage disequilibrium between loci were tested by SNPAnalyzer v2.0 software. Based on the allele frequencies of 30 InDel loci, the genetic relationships between Ewenki ethnic group and other populations were evaluated by analysis of molecular variance, principal component analysis and phylogenetic reconstruction. Results After correction, 30 InDel loci conformed to Hardy-Weinberg equilibrium. It was found that the pairwise InDel loci were in linkage equilibrium after Bonferroni correction. The results of population genetics indicated that Ewenki ethnic group had close genetic relationships with Henan Han and Beijing Han populations; whereas it was significantly different from several populations in Europe and Mexico. Conclusion There are relatively high genetic polymorphisms on 30 InDel loci of Ewenki ethnic group from Inner Mongolia, which can be used as a helpful supplement application for STR detection system. Article in Journal/Newspaper Ewenki Directory of Open Access Journals: DOAJ Articles |
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Directory of Open Access Journals: DOAJ Articles |
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topic |
forensic genetics polymorphism,genetic insertion/deletion ewenki ethnic group inner mongolia Medicine R |
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forensic genetics polymorphism,genetic insertion/deletion ewenki ethnic group inner mongolia Medicine R JIN XIAO-YE WEI YUAN-YUAN HE YONG-FENG Genetic Polymorphisms of 30 InDel Loci in Ewenki Ethnic Group from Inner Mongolia |
topic_facet |
forensic genetics polymorphism,genetic insertion/deletion ewenki ethnic group inner mongolia Medicine R |
description |
Objective To study the genetic polymorphisms of 30 insertion/deletion (InDel) loci and evaluate their forensic application in Ewenki ethnic group from Inner Mongolia. Methods Peripheral blood samples were collected from 87 unrelated healthy individuals in Ewenki ethnic group. Genomic DNA were extracted, and 30 InDel loci of the samples were multiplex amplified and genotyped. Hardy-Weinberg balance tests were preformed for all loci and genetic parameters were calculated by modified PowerStats v1.2 software. The linkage disequilibrium between loci were tested by SNPAnalyzer v2.0 software. Based on the allele frequencies of 30 InDel loci, the genetic relationships between Ewenki ethnic group and other populations were evaluated by analysis of molecular variance, principal component analysis and phylogenetic reconstruction. Results After correction, 30 InDel loci conformed to Hardy-Weinberg equilibrium. It was found that the pairwise InDel loci were in linkage equilibrium after Bonferroni correction. The results of population genetics indicated that Ewenki ethnic group had close genetic relationships with Henan Han and Beijing Han populations; whereas it was significantly different from several populations in Europe and Mexico. Conclusion There are relatively high genetic polymorphisms on 30 InDel loci of Ewenki ethnic group from Inner Mongolia, which can be used as a helpful supplement application for STR detection system. |
format |
Article in Journal/Newspaper |
author |
JIN XIAO-YE WEI YUAN-YUAN HE YONG-FENG |
author_facet |
JIN XIAO-YE WEI YUAN-YUAN HE YONG-FENG |
author_sort |
JIN XIAO-YE |
title |
Genetic Polymorphisms of 30 InDel Loci in Ewenki Ethnic Group from Inner Mongolia |
title_short |
Genetic Polymorphisms of 30 InDel Loci in Ewenki Ethnic Group from Inner Mongolia |
title_full |
Genetic Polymorphisms of 30 InDel Loci in Ewenki Ethnic Group from Inner Mongolia |
title_fullStr |
Genetic Polymorphisms of 30 InDel Loci in Ewenki Ethnic Group from Inner Mongolia |
title_full_unstemmed |
Genetic Polymorphisms of 30 InDel Loci in Ewenki Ethnic Group from Inner Mongolia |
title_sort |
genetic polymorphisms of 30 indel loci in ewenki ethnic group from inner mongolia |
publisher |
Editorial Office of Journal of Forensic Medicine |
publishDate |
2017 |
url |
https://doi.org/10.3969/j.issn.1004-5619.2017.03.012 https://doaj.org/article/62b81c5e0fb34a2eaf3d2aefc35c6e28 |
genre |
Ewenki |
genre_facet |
Ewenki |
op_source |
Fayixue Zazhi, Vol 33, Iss 3, Pp 271-276 (2017) |
op_relation |
http://www.fyxzz.cn/fileup/1004-5619/PDF/FYXZZ201703012.pdf https://doaj.org/toc/1004-5619 1004-5619 doi:10.3969/j.issn.1004-5619.2017.03.012 https://doaj.org/article/62b81c5e0fb34a2eaf3d2aefc35c6e28 |
op_doi |
https://doi.org/10.3969/j.issn.1004-5619.2017.03.012 |
_version_ |
1810442904761532416 |