Aorta of young and middle-aged heterozygous familial hypercholesterolemia patients shows no functional or morphological impairment assessed by MRI
Sami Soljanlahti1, Taina Autti1, Alpo F Vuorio2, Pekka Keto1, Hannu Turtola3, Kirsi Lauerma11Helsinki Medical Imaging Center, Helsinki University Central Hospital, Helsinki, Finland; 2Division of Internal Medicine, Department of Medicine, University of Helsinki, Helsinki, Finland; 3Department of Int...
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ftdoajarticles:oai:doaj.org/article:62aa8f9f63854e2789fe6f4c2b7bc3ea 2023-05-15T17:00:12+02:00 Aorta of young and middle-aged heterozygous familial hypercholesterolemia patients shows no functional or morphological impairment assessed by MRI Sami Soljanlahti Taina Autti Alpo F Vuorio Pekka Keto Hannu Turtola Kirsi Lauerma 2008-08-01T00:00:00Z https://doaj.org/article/62aa8f9f63854e2789fe6f4c2b7bc3ea EN eng Dove Medical Press https://www.dovepress.com/aorta-of-young-and-middle-aged-heterozygous-familial-hypercholesterole-peer-reviewed-article-VHRM https://doaj.org/toc/1178-2048 1178-2048 https://doaj.org/article/62aa8f9f63854e2789fe6f4c2b7bc3ea Vascular Health and Risk Management, Vol Volume 4, Pp 923-929 (2008) MRI Ultrasound Atherosclerosis Aorta Familial Hypercholesterolemia Diseases of the circulatory (Cardiovascular) system RC666-701 article 2008 ftdoajarticles 2022-12-31T14:30:53Z Sami Soljanlahti1, Taina Autti1, Alpo F Vuorio2, Pekka Keto1, Hannu Turtola3, Kirsi Lauerma11Helsinki Medical Imaging Center, Helsinki University Central Hospital, Helsinki, Finland; 2Division of Internal Medicine, Department of Medicine, University of Helsinki, Helsinki, Finland; 3Department of Internal Medicine, North Karelia Central Hospital, Joensuu, FinlandAbstract: In familial hypercholesterolemia (FH) the level of LDL cholesterol is 2–3 times that of the normal population and leads to accelerated atherosclerosis. Improved care for risk factors has decreased cardiovascular mortality of these patients. We studied subclinical atherosclerotic changes with morphologic and functional aortic magnetic resonance imaging (MRI) in FH patients under the age of 50. 39 DNA test-verified heterozygous FH-North Karelia patients, aged 6–48, 28 of them treated with statins, and 25 healthy controls, aged 12 to 50, underwent aortic MRI, carotid ultrasound (US), and risk-factor assessment. No differences in any of the morphologic or functional aortic parameters appeared between patients and controls. Age and gender were independent predictors of the majority of the morphologic and functional measures. Carotid intima-media thickness assessed by US was greater in patients (0.57 mm ± 0.13 vs 0.48 ± 0.13 mm, p = 0.005) as was cholesterol-years score (243 ± 122 vs 137 ± 74, p < 0.001). Patients had thicker intima-media of the common carotid artery and higher cholesterol burden as indicated by their cholesterol-years score. Despite this, no differences existed in morphologic or functional aortic parameters assessed with MRI. The improved care of cardiovascular risk factors, especially statin treatment, may protect the aorta of FH patients. However, larger confirmatory studies are needed.Keywords: MRI, ultrasound, atherosclerosis, aorta, familial hypercholesterolemia Article in Journal/Newspaper karelia* sami Directory of Open Access Journals: DOAJ Articles Pekka ENVELOPE(23.816,23.816,66.180,66.180) |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
MRI Ultrasound Atherosclerosis Aorta Familial Hypercholesterolemia Diseases of the circulatory (Cardiovascular) system RC666-701 |
spellingShingle |
MRI Ultrasound Atherosclerosis Aorta Familial Hypercholesterolemia Diseases of the circulatory (Cardiovascular) system RC666-701 Sami Soljanlahti Taina Autti Alpo F Vuorio Pekka Keto Hannu Turtola Kirsi Lauerma Aorta of young and middle-aged heterozygous familial hypercholesterolemia patients shows no functional or morphological impairment assessed by MRI |
topic_facet |
MRI Ultrasound Atherosclerosis Aorta Familial Hypercholesterolemia Diseases of the circulatory (Cardiovascular) system RC666-701 |
description |
Sami Soljanlahti1, Taina Autti1, Alpo F Vuorio2, Pekka Keto1, Hannu Turtola3, Kirsi Lauerma11Helsinki Medical Imaging Center, Helsinki University Central Hospital, Helsinki, Finland; 2Division of Internal Medicine, Department of Medicine, University of Helsinki, Helsinki, Finland; 3Department of Internal Medicine, North Karelia Central Hospital, Joensuu, FinlandAbstract: In familial hypercholesterolemia (FH) the level of LDL cholesterol is 2–3 times that of the normal population and leads to accelerated atherosclerosis. Improved care for risk factors has decreased cardiovascular mortality of these patients. We studied subclinical atherosclerotic changes with morphologic and functional aortic magnetic resonance imaging (MRI) in FH patients under the age of 50. 39 DNA test-verified heterozygous FH-North Karelia patients, aged 6–48, 28 of them treated with statins, and 25 healthy controls, aged 12 to 50, underwent aortic MRI, carotid ultrasound (US), and risk-factor assessment. No differences in any of the morphologic or functional aortic parameters appeared between patients and controls. Age and gender were independent predictors of the majority of the morphologic and functional measures. Carotid intima-media thickness assessed by US was greater in patients (0.57 mm ± 0.13 vs 0.48 ± 0.13 mm, p = 0.005) as was cholesterol-years score (243 ± 122 vs 137 ± 74, p < 0.001). Patients had thicker intima-media of the common carotid artery and higher cholesterol burden as indicated by their cholesterol-years score. Despite this, no differences existed in morphologic or functional aortic parameters assessed with MRI. The improved care of cardiovascular risk factors, especially statin treatment, may protect the aorta of FH patients. However, larger confirmatory studies are needed.Keywords: MRI, ultrasound, atherosclerosis, aorta, familial hypercholesterolemia |
format |
Article in Journal/Newspaper |
author |
Sami Soljanlahti Taina Autti Alpo F Vuorio Pekka Keto Hannu Turtola Kirsi Lauerma |
author_facet |
Sami Soljanlahti Taina Autti Alpo F Vuorio Pekka Keto Hannu Turtola Kirsi Lauerma |
author_sort |
Sami Soljanlahti |
title |
Aorta of young and middle-aged heterozygous familial hypercholesterolemia patients shows no functional or morphological impairment assessed by MRI |
title_short |
Aorta of young and middle-aged heterozygous familial hypercholesterolemia patients shows no functional or morphological impairment assessed by MRI |
title_full |
Aorta of young and middle-aged heterozygous familial hypercholesterolemia patients shows no functional or morphological impairment assessed by MRI |
title_fullStr |
Aorta of young and middle-aged heterozygous familial hypercholesterolemia patients shows no functional or morphological impairment assessed by MRI |
title_full_unstemmed |
Aorta of young and middle-aged heterozygous familial hypercholesterolemia patients shows no functional or morphological impairment assessed by MRI |
title_sort |
aorta of young and middle-aged heterozygous familial hypercholesterolemia patients shows no functional or morphological impairment assessed by mri |
publisher |
Dove Medical Press |
publishDate |
2008 |
url |
https://doaj.org/article/62aa8f9f63854e2789fe6f4c2b7bc3ea |
long_lat |
ENVELOPE(23.816,23.816,66.180,66.180) |
geographic |
Pekka |
geographic_facet |
Pekka |
genre |
karelia* sami |
genre_facet |
karelia* sami |
op_source |
Vascular Health and Risk Management, Vol Volume 4, Pp 923-929 (2008) |
op_relation |
https://www.dovepress.com/aorta-of-young-and-middle-aged-heterozygous-familial-hypercholesterole-peer-reviewed-article-VHRM https://doaj.org/toc/1178-2048 1178-2048 https://doaj.org/article/62aa8f9f63854e2789fe6f4c2b7bc3ea |
_version_ |
1766052837923487744 |