The burden of scrub typhus in India: A systematic review.
Background Scrub typhus, a vector-borne zoonotic infection caused by the bacteria Orientia tsutsugamushi, is one of the most common and clinically important rickettsial infections worldwide. An estimated one million cases occur annually with a high case fatality rate. Although scrub typhus is a majo...
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ftdoajarticles:oai:doaj.org/article:62670f63a47442fdad6de6d4b7da28c2 2023-05-15T15:15:16+02:00 The burden of scrub typhus in India: A systematic review. Emily Devasagayam Divya Dayanand Debasree Kundu Mohan S Kamath Richard Kirubakaran George M Varghese 2021-07-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0009619 https://doaj.org/article/62670f63a47442fdad6de6d4b7da28c2 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0009619 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0009619 https://doaj.org/article/62670f63a47442fdad6de6d4b7da28c2 PLoS Neglected Tropical Diseases, Vol 15, Iss 7, p e0009619 (2021) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2021 ftdoajarticles https://doi.org/10.1371/journal.pntd.0009619 2022-12-31T15:49:17Z Background Scrub typhus, a vector-borne zoonotic infection caused by the bacteria Orientia tsutsugamushi, is one of the most common and clinically important rickettsial infections worldwide. An estimated one million cases occur annually with a high case fatality rate. Although scrub typhus is a major public health threat in India, the burden and distribution remains unclear. We aimed to estimate the burden of scrub typhus in India. Methodology We performed a systematic review of published literature on scrub typhus from India to extract information on epidemiology, morbidity, and mortality. Important databases were searched using keywords and appropriate combinations. We identified observational, interventional, and population-based studies and extracted the data to evaluate the number of cases diagnosed using serology or PCR and the number of deaths due to scrub typhus. We conducted a systematic narrative synthesis to summarize included studies. Principal findings In the last decade, there were 18,781 confirmed scrub typhus cases reported in 138 hospital-based studies and two community-based studies. IgM ELISA was used in 122 studies to confirm the cases in majority (89%). The proportion of scrub typhus among acute undifferentiated febrile illness (AUFI) studies was 25.3%, and community seroprevalence was 34.2%. Ninety studies had data published on multiple organ involvement out of which 17.4% of cases had multiple organ dysfunction syndromes, 20.4% patients required ICU admission, and 19.1% needed ventilation. The overall case-fatality rate was 6.3%, and the mortality among those with multi-organ dysfunction syndrome was as high as 38.9%. Conclusion/significance Scrub typhus, a common acute febrile illness in India causing severe morbidity, accounts for a large number of deaths. The burden of the disease has been underappreciated. Early diagnosis and prompt treatment can significantly reduce complications and mortality. Establishing good surveillance and instituting appropriate control measures are urgently ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 15 7 e0009619 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Emily Devasagayam Divya Dayanand Debasree Kundu Mohan S Kamath Richard Kirubakaran George M Varghese The burden of scrub typhus in India: A systematic review. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Background Scrub typhus, a vector-borne zoonotic infection caused by the bacteria Orientia tsutsugamushi, is one of the most common and clinically important rickettsial infections worldwide. An estimated one million cases occur annually with a high case fatality rate. Although scrub typhus is a major public health threat in India, the burden and distribution remains unclear. We aimed to estimate the burden of scrub typhus in India. Methodology We performed a systematic review of published literature on scrub typhus from India to extract information on epidemiology, morbidity, and mortality. Important databases were searched using keywords and appropriate combinations. We identified observational, interventional, and population-based studies and extracted the data to evaluate the number of cases diagnosed using serology or PCR and the number of deaths due to scrub typhus. We conducted a systematic narrative synthesis to summarize included studies. Principal findings In the last decade, there were 18,781 confirmed scrub typhus cases reported in 138 hospital-based studies and two community-based studies. IgM ELISA was used in 122 studies to confirm the cases in majority (89%). The proportion of scrub typhus among acute undifferentiated febrile illness (AUFI) studies was 25.3%, and community seroprevalence was 34.2%. Ninety studies had data published on multiple organ involvement out of which 17.4% of cases had multiple organ dysfunction syndromes, 20.4% patients required ICU admission, and 19.1% needed ventilation. The overall case-fatality rate was 6.3%, and the mortality among those with multi-organ dysfunction syndrome was as high as 38.9%. Conclusion/significance Scrub typhus, a common acute febrile illness in India causing severe morbidity, accounts for a large number of deaths. The burden of the disease has been underappreciated. Early diagnosis and prompt treatment can significantly reduce complications and mortality. Establishing good surveillance and instituting appropriate control measures are urgently ... |
format |
Article in Journal/Newspaper |
author |
Emily Devasagayam Divya Dayanand Debasree Kundu Mohan S Kamath Richard Kirubakaran George M Varghese |
author_facet |
Emily Devasagayam Divya Dayanand Debasree Kundu Mohan S Kamath Richard Kirubakaran George M Varghese |
author_sort |
Emily Devasagayam |
title |
The burden of scrub typhus in India: A systematic review. |
title_short |
The burden of scrub typhus in India: A systematic review. |
title_full |
The burden of scrub typhus in India: A systematic review. |
title_fullStr |
The burden of scrub typhus in India: A systematic review. |
title_full_unstemmed |
The burden of scrub typhus in India: A systematic review. |
title_sort |
burden of scrub typhus in india: a systematic review. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2021 |
url |
https://doi.org/10.1371/journal.pntd.0009619 https://doaj.org/article/62670f63a47442fdad6de6d4b7da28c2 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 15, Iss 7, p e0009619 (2021) |
op_relation |
https://doi.org/10.1371/journal.pntd.0009619 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0009619 https://doaj.org/article/62670f63a47442fdad6de6d4b7da28c2 |
op_doi |
https://doi.org/10.1371/journal.pntd.0009619 |
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PLOS Neglected Tropical Diseases |
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15 |
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e0009619 |
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