The dispersal ecology of Rhodesian sleeping sickness following its introduction to a new area.
Tsetse-transmitted human and animal trypanosomiasis are constraints to both human and animal health in sub-Saharan Africa, and although these diseases have been known for over a century, there is little recent evidence demonstrating how the parasites circulate in natural hosts and ecosystems. The sp...
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ftdoajarticles:oai:doaj.org/article:62492ae85fab4751b15ccc44b592c7cd 2023-05-15T15:10:47+02:00 The dispersal ecology of Rhodesian sleeping sickness following its introduction to a new area. Nicola A Wardrop Eric M Fèvre Peter M Atkinson Susan C Welburn 2013-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0002485 https://doaj.org/article/62492ae85fab4751b15ccc44b592c7cd EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC3794918?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0002485 https://doaj.org/article/62492ae85fab4751b15ccc44b592c7cd PLoS Neglected Tropical Diseases, Vol 7, Iss 10, p e2485 (2013) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2013 ftdoajarticles https://doi.org/10.1371/journal.pntd.0002485 2023-01-08T01:27:25Z Tsetse-transmitted human and animal trypanosomiasis are constraints to both human and animal health in sub-Saharan Africa, and although these diseases have been known for over a century, there is little recent evidence demonstrating how the parasites circulate in natural hosts and ecosystems. The spread of Rhodesian sleeping sickness (caused by Trypanosoma brucei rhodesiense) within Uganda over the past 15 years has been linked to the movement of infected, untreated livestock (the predominant reservoir) from endemic areas. However, despite an understanding of the environmental dependencies of sleeping sickness, little research has focused on the environmental factors controlling transmission establishment or the spatially heterogeneous dispersal of disease following a new introduction. In the current study, an annually stratified case-control study of Rhodesian sleeping sickness cases from Serere District, Uganda was used to allow the temporal assessment of correlations between the spatial distribution of sleeping sickness and landscape factors. Significant relationships were detected between Rhodesian sleeping sickness and selected factors, including elevation and the proportion of land which was "seasonally flooding grassland" or "woodlands and dense savannah." Temporal trends in these relationships were detected, illustrating the dispersal of Rhodesian sleeping sickness into more 'suitable' areas over time, with diminishing dependence on the point of introduction in concurrence with an increasing dependence on environmental and landscape factors. These results provide a novel insight into the ecology of Rhodesian sleeping sickness dispersal and may contribute towards the implementation of evidence-based control measures to prevent its further spread. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 7 10 e2485 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Nicola A Wardrop Eric M Fèvre Peter M Atkinson Susan C Welburn The dispersal ecology of Rhodesian sleeping sickness following its introduction to a new area. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Tsetse-transmitted human and animal trypanosomiasis are constraints to both human and animal health in sub-Saharan Africa, and although these diseases have been known for over a century, there is little recent evidence demonstrating how the parasites circulate in natural hosts and ecosystems. The spread of Rhodesian sleeping sickness (caused by Trypanosoma brucei rhodesiense) within Uganda over the past 15 years has been linked to the movement of infected, untreated livestock (the predominant reservoir) from endemic areas. However, despite an understanding of the environmental dependencies of sleeping sickness, little research has focused on the environmental factors controlling transmission establishment or the spatially heterogeneous dispersal of disease following a new introduction. In the current study, an annually stratified case-control study of Rhodesian sleeping sickness cases from Serere District, Uganda was used to allow the temporal assessment of correlations between the spatial distribution of sleeping sickness and landscape factors. Significant relationships were detected between Rhodesian sleeping sickness and selected factors, including elevation and the proportion of land which was "seasonally flooding grassland" or "woodlands and dense savannah." Temporal trends in these relationships were detected, illustrating the dispersal of Rhodesian sleeping sickness into more 'suitable' areas over time, with diminishing dependence on the point of introduction in concurrence with an increasing dependence on environmental and landscape factors. These results provide a novel insight into the ecology of Rhodesian sleeping sickness dispersal and may contribute towards the implementation of evidence-based control measures to prevent its further spread. |
format |
Article in Journal/Newspaper |
author |
Nicola A Wardrop Eric M Fèvre Peter M Atkinson Susan C Welburn |
author_facet |
Nicola A Wardrop Eric M Fèvre Peter M Atkinson Susan C Welburn |
author_sort |
Nicola A Wardrop |
title |
The dispersal ecology of Rhodesian sleeping sickness following its introduction to a new area. |
title_short |
The dispersal ecology of Rhodesian sleeping sickness following its introduction to a new area. |
title_full |
The dispersal ecology of Rhodesian sleeping sickness following its introduction to a new area. |
title_fullStr |
The dispersal ecology of Rhodesian sleeping sickness following its introduction to a new area. |
title_full_unstemmed |
The dispersal ecology of Rhodesian sleeping sickness following its introduction to a new area. |
title_sort |
dispersal ecology of rhodesian sleeping sickness following its introduction to a new area. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2013 |
url |
https://doi.org/10.1371/journal.pntd.0002485 https://doaj.org/article/62492ae85fab4751b15ccc44b592c7cd |
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Arctic |
geographic_facet |
Arctic |
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Arctic |
genre_facet |
Arctic |
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PLoS Neglected Tropical Diseases, Vol 7, Iss 10, p e2485 (2013) |
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http://europepmc.org/articles/PMC3794918?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0002485 https://doaj.org/article/62492ae85fab4751b15ccc44b592c7cd |
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https://doi.org/10.1371/journal.pntd.0002485 |
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PLoS Neglected Tropical Diseases |
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e2485 |
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