An evolutionary learning and network approach to identifying key metabolites for osteoarthritis.
Metabolomics studies use quantitative analyses of metabolites from body fluids or tissues in order to investigate a sequence of cellular processes and biological systems in response to genetic and environmental influences. This promises an immense potential for a better understanding of the pathogen...
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ftdoajarticles:oai:doaj.org/article:61cf9fa11f5547be8c6e6431103b8f8c 2023-05-15T17:22:23+02:00 An evolutionary learning and network approach to identifying key metabolites for osteoarthritis. Ting Hu Karoliina Oksanen Weidong Zhang Ed Randell Andrew Furey Guang Sun Guangju Zhai 2018-03-01T00:00:00Z https://doi.org/10.1371/journal.pcbi.1005986 https://doaj.org/article/61cf9fa11f5547be8c6e6431103b8f8c EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC5849325?pdf=render https://doaj.org/toc/1553-734X https://doaj.org/toc/1553-7358 1553-734X 1553-7358 doi:10.1371/journal.pcbi.1005986 https://doaj.org/article/61cf9fa11f5547be8c6e6431103b8f8c PLoS Computational Biology, Vol 14, Iss 3, p e1005986 (2018) Biology (General) QH301-705.5 article 2018 ftdoajarticles https://doi.org/10.1371/journal.pcbi.1005986 2022-12-31T02:24:08Z Metabolomics studies use quantitative analyses of metabolites from body fluids or tissues in order to investigate a sequence of cellular processes and biological systems in response to genetic and environmental influences. This promises an immense potential for a better understanding of the pathogenesis of complex diseases. Most conventional metabolomics analysis methods exam one metabolite at a time and may overlook the synergistic effect of combining multiple metabolites. In this article, we proposed a new bioinformatics framework that infers the non-linear synergy among multiple metabolites using a symbolic model and subsequently, identify key metabolites using network analysis. Such a symbolic model is able to represent a complex non-linear relationship among a set of metabolites associated with osteoarthritis (OA) and is automatically learned using an evolutionary algorithm. Applied to the Newfoundland Osteoarthritis Study (NFOAS) dataset, our methodology was able to identify nine key metabolites including some known osteoarthritis-associated metabolites and some novel metabolic markers that have never been reported before. The results demonstrate the effectiveness of our methodology and more importantly, with further investigations, propose new hypotheses that can help better understand the OA disease. Article in Journal/Newspaper Newfoundland Directory of Open Access Journals: DOAJ Articles PLOS Computational Biology 14 3 e1005986 |
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Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Biology (General) QH301-705.5 |
spellingShingle |
Biology (General) QH301-705.5 Ting Hu Karoliina Oksanen Weidong Zhang Ed Randell Andrew Furey Guang Sun Guangju Zhai An evolutionary learning and network approach to identifying key metabolites for osteoarthritis. |
topic_facet |
Biology (General) QH301-705.5 |
description |
Metabolomics studies use quantitative analyses of metabolites from body fluids or tissues in order to investigate a sequence of cellular processes and biological systems in response to genetic and environmental influences. This promises an immense potential for a better understanding of the pathogenesis of complex diseases. Most conventional metabolomics analysis methods exam one metabolite at a time and may overlook the synergistic effect of combining multiple metabolites. In this article, we proposed a new bioinformatics framework that infers the non-linear synergy among multiple metabolites using a symbolic model and subsequently, identify key metabolites using network analysis. Such a symbolic model is able to represent a complex non-linear relationship among a set of metabolites associated with osteoarthritis (OA) and is automatically learned using an evolutionary algorithm. Applied to the Newfoundland Osteoarthritis Study (NFOAS) dataset, our methodology was able to identify nine key metabolites including some known osteoarthritis-associated metabolites and some novel metabolic markers that have never been reported before. The results demonstrate the effectiveness of our methodology and more importantly, with further investigations, propose new hypotheses that can help better understand the OA disease. |
format |
Article in Journal/Newspaper |
author |
Ting Hu Karoliina Oksanen Weidong Zhang Ed Randell Andrew Furey Guang Sun Guangju Zhai |
author_facet |
Ting Hu Karoliina Oksanen Weidong Zhang Ed Randell Andrew Furey Guang Sun Guangju Zhai |
author_sort |
Ting Hu |
title |
An evolutionary learning and network approach to identifying key metabolites for osteoarthritis. |
title_short |
An evolutionary learning and network approach to identifying key metabolites for osteoarthritis. |
title_full |
An evolutionary learning and network approach to identifying key metabolites for osteoarthritis. |
title_fullStr |
An evolutionary learning and network approach to identifying key metabolites for osteoarthritis. |
title_full_unstemmed |
An evolutionary learning and network approach to identifying key metabolites for osteoarthritis. |
title_sort |
evolutionary learning and network approach to identifying key metabolites for osteoarthritis. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2018 |
url |
https://doi.org/10.1371/journal.pcbi.1005986 https://doaj.org/article/61cf9fa11f5547be8c6e6431103b8f8c |
genre |
Newfoundland |
genre_facet |
Newfoundland |
op_source |
PLoS Computational Biology, Vol 14, Iss 3, p e1005986 (2018) |
op_relation |
http://europepmc.org/articles/PMC5849325?pdf=render https://doaj.org/toc/1553-734X https://doaj.org/toc/1553-7358 1553-734X 1553-7358 doi:10.1371/journal.pcbi.1005986 https://doaj.org/article/61cf9fa11f5547be8c6e6431103b8f8c |
op_doi |
https://doi.org/10.1371/journal.pcbi.1005986 |
container_title |
PLOS Computational Biology |
container_volume |
14 |
container_issue |
3 |
container_start_page |
e1005986 |
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1766109025092501504 |