Cone snail species off the Brazilian coast and their venoms: a review and update
Abstract The genus Conus includes over 900 species of marine invertebrates known as cone snails, whose venoms are among the most powerful described so far. This potency is mainly due to the concerted action of hundreds of small bioactive peptides named conopeptides, which target different ion channe...
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ftdoajarticles:oai:doaj.org/article:61cd238f895044068c1b0a0b97b33948 2023-05-15T15:13:05+02:00 Cone snail species off the Brazilian coast and their venoms: a review and update Helena B. Fiorotti Suely G. Figueiredo Fabiana V. Campos Daniel C. Pimenta 2023-01-01T00:00:00Z https://doi.org/10.1590/1678-9199-jvatitd-2022-0052 https://doaj.org/article/61cd238f895044068c1b0a0b97b33948 EN eng SciELO http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992023000100201&tlng=en https://doaj.org/toc/1678-9199 1678-9199 doi:10.1590/1678-9199-jvatitd-2022-0052 https://doaj.org/article/61cd238f895044068c1b0a0b97b33948 Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 29 (2023) Conus Cone snail Brazilian coast Venom Conopeptides Conotoxins Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 article 2023 ftdoajarticles https://doi.org/10.1590/1678-9199-jvatitd-2022-0052 2023-02-12T01:31:16Z Abstract The genus Conus includes over 900 species of marine invertebrates known as cone snails, whose venoms are among the most powerful described so far. This potency is mainly due to the concerted action of hundreds of small bioactive peptides named conopeptides, which target different ion channels and membrane receptors and thus interfere with crucial physiological processes. By swiftly harpooning and injecting their prey and predators with such deadly cocktails, the slow-moving cone snails guarantee their survival in the harsh, competitive marine environment. Each cone snail species produces a unique venom, as the mature sequences of conopeptides from the venoms of different species share very little identity. This biochemical diversity, added to the numerous species and conopeptides contained in their venoms, results in an immense biotechnological and therapeutic potential, still largely unexplored. That is especially true regarding the bioprospection of the venoms of cone snail species found off the Brazilian coast - a region widely known for its biodiversity. Of the 31 species described in this region so far, only four - Conus cancellatus, Conus regius, Conus villepinii, and Conus ermineus - have had their venoms partially characterized, and, although many bioactive molecules have been identified, only a few have been actually isolated and studied. In addition to providing an overview on all the cone snail species found off the Brazilian coast to date, this review compiles the information on the structural and pharmacological features of conopeptides and other molecules identified in the venoms of the four aforementioned species, paving the way for future studies. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Journal of Venomous Animals and Toxins including Tropical Diseases 29 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Conus Cone snail Brazilian coast Venom Conopeptides Conotoxins Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
spellingShingle |
Conus Cone snail Brazilian coast Venom Conopeptides Conotoxins Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 Helena B. Fiorotti Suely G. Figueiredo Fabiana V. Campos Daniel C. Pimenta Cone snail species off the Brazilian coast and their venoms: a review and update |
topic_facet |
Conus Cone snail Brazilian coast Venom Conopeptides Conotoxins Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
description |
Abstract The genus Conus includes over 900 species of marine invertebrates known as cone snails, whose venoms are among the most powerful described so far. This potency is mainly due to the concerted action of hundreds of small bioactive peptides named conopeptides, which target different ion channels and membrane receptors and thus interfere with crucial physiological processes. By swiftly harpooning and injecting their prey and predators with such deadly cocktails, the slow-moving cone snails guarantee their survival in the harsh, competitive marine environment. Each cone snail species produces a unique venom, as the mature sequences of conopeptides from the venoms of different species share very little identity. This biochemical diversity, added to the numerous species and conopeptides contained in their venoms, results in an immense biotechnological and therapeutic potential, still largely unexplored. That is especially true regarding the bioprospection of the venoms of cone snail species found off the Brazilian coast - a region widely known for its biodiversity. Of the 31 species described in this region so far, only four - Conus cancellatus, Conus regius, Conus villepinii, and Conus ermineus - have had their venoms partially characterized, and, although many bioactive molecules have been identified, only a few have been actually isolated and studied. In addition to providing an overview on all the cone snail species found off the Brazilian coast to date, this review compiles the information on the structural and pharmacological features of conopeptides and other molecules identified in the venoms of the four aforementioned species, paving the way for future studies. |
format |
Article in Journal/Newspaper |
author |
Helena B. Fiorotti Suely G. Figueiredo Fabiana V. Campos Daniel C. Pimenta |
author_facet |
Helena B. Fiorotti Suely G. Figueiredo Fabiana V. Campos Daniel C. Pimenta |
author_sort |
Helena B. Fiorotti |
title |
Cone snail species off the Brazilian coast and their venoms: a review and update |
title_short |
Cone snail species off the Brazilian coast and their venoms: a review and update |
title_full |
Cone snail species off the Brazilian coast and their venoms: a review and update |
title_fullStr |
Cone snail species off the Brazilian coast and their venoms: a review and update |
title_full_unstemmed |
Cone snail species off the Brazilian coast and their venoms: a review and update |
title_sort |
cone snail species off the brazilian coast and their venoms: a review and update |
publisher |
SciELO |
publishDate |
2023 |
url |
https://doi.org/10.1590/1678-9199-jvatitd-2022-0052 https://doaj.org/article/61cd238f895044068c1b0a0b97b33948 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 29 (2023) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992023000100201&tlng=en https://doaj.org/toc/1678-9199 1678-9199 doi:10.1590/1678-9199-jvatitd-2022-0052 https://doaj.org/article/61cd238f895044068c1b0a0b97b33948 |
op_doi |
https://doi.org/10.1590/1678-9199-jvatitd-2022-0052 |
container_title |
Journal of Venomous Animals and Toxins including Tropical Diseases |
container_volume |
29 |
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