Presumptive treatment with sulphadoxine-pyrimethamine versus weekly chloroquine for malaria prophylaxis in children with sickle cell anaemia in Uganda: a randomized controlled trial

• Published in: Malaria Journal
• Main Authors: Ndugwa Christopher M, Nakiboneka Deborah, Ndeezi Grace, Nakibuuka Victoria, Tumwine James K
• Format: Article in Journal/Newspaper
• Language: English
• Published: BMC 2009
• Subjects: Arctic medicine. Tropical medicine; RC955-962; Infectious and parasitic diseases; RC109-216; Arctic; Sickle
• Online Access: https://doi.org/10.1186/1475-2875-8-237; https://doaj.org/article/61a4faef480a42a8918928d367155d23

Abstract Background Malaria carries high case fatality among children with sickle cell anaemia. In Uganda, chloroquine is used for prophylaxis in these children despite unacceptably high levels of resistance. Intermittent presumptive treatment with sulphadoxine-pyrimethamine (SP) has shown great pot...