Synergism between prior Anisakis simplex infections and intake of NSAIDs, on the risk of upper digestive bleeding: a case-control study.
BACKGROUND: The aim of this study was to investigate the relationship between prior Anisakis infections and upper gastrointestinal bleeding (UGIB), and its interaction with non-steroidal anti-inflammatory drug (NSAID) intake. METHODS/PRINCIPAL FINDINGS: We conducted a hospital-based case-control stu...
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ftdoajarticles:oai:doaj.org/article:61927fe7951149debc1104ea7e8760ea 2023-05-15T15:08:27+02:00 Synergism between prior Anisakis simplex infections and intake of NSAIDs, on the risk of upper digestive bleeding: a case-control study. Florencio M Ubeira Ana M Anadón Angel Salgado Alfonso Carvajal Sara Ortega Carmelo Aguirre María José López-Goikoetxea Luisa Ibanez Adolfo Figueiras 2011-06-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0001214 https://doaj.org/article/61927fe7951149debc1104ea7e8760ea EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC3125143?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0001214 https://doaj.org/article/61927fe7951149debc1104ea7e8760ea PLoS Neglected Tropical Diseases, Vol 5, Iss 6, p e1214 (2011) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2011 ftdoajarticles https://doi.org/10.1371/journal.pntd.0001214 2022-12-31T15:44:55Z BACKGROUND: The aim of this study was to investigate the relationship between prior Anisakis infections and upper gastrointestinal bleeding (UGIB), and its interaction with non-steroidal anti-inflammatory drug (NSAID) intake. METHODS/PRINCIPAL FINDINGS: We conducted a hospital-based case-control study covering 215 UGIB cases and 650 controls. Odds ratios (ORs) with their confidence intervals (95% CIs) were calculated, as well as the ratio of the combined effects to the sum of the separate effects of Anisakis allergic sensitization and NSAIDs intake. Prior Anisakis infections were revealed by the presence of anti-Anisakis IgE antibodies specific to the recombinant Ani s 1 and Ani s 7 allergens used as the targets in indirect ELISA. Prior Anisakis infections (OR 1.74 [95% CI: 1.10 to 2.75]) and the intake of NSAIDs (OR 6.63 [95% CI: 4.21 to 10.43]) increased the risk of bleeding. Simultaneous NSAIDs intake and Anisakis allergic sensitization increased the risk of UGIB 14-fold (OR=14.46 [95% CI: 6.08 to 34.40]). This interaction was additive, with a synergistic index of 3.01 (95% CI: 1.18-7.71). CONCLUSIONS: Prior Anisakis infection is an independent risk factor for UGIB, and the joint effect with NSAIDs is 3 times higher than the sum of their individual effects. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 5 6 e1214 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Florencio M Ubeira Ana M Anadón Angel Salgado Alfonso Carvajal Sara Ortega Carmelo Aguirre María José López-Goikoetxea Luisa Ibanez Adolfo Figueiras Synergism between prior Anisakis simplex infections and intake of NSAIDs, on the risk of upper digestive bleeding: a case-control study. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
BACKGROUND: The aim of this study was to investigate the relationship between prior Anisakis infections and upper gastrointestinal bleeding (UGIB), and its interaction with non-steroidal anti-inflammatory drug (NSAID) intake. METHODS/PRINCIPAL FINDINGS: We conducted a hospital-based case-control study covering 215 UGIB cases and 650 controls. Odds ratios (ORs) with their confidence intervals (95% CIs) were calculated, as well as the ratio of the combined effects to the sum of the separate effects of Anisakis allergic sensitization and NSAIDs intake. Prior Anisakis infections were revealed by the presence of anti-Anisakis IgE antibodies specific to the recombinant Ani s 1 and Ani s 7 allergens used as the targets in indirect ELISA. Prior Anisakis infections (OR 1.74 [95% CI: 1.10 to 2.75]) and the intake of NSAIDs (OR 6.63 [95% CI: 4.21 to 10.43]) increased the risk of bleeding. Simultaneous NSAIDs intake and Anisakis allergic sensitization increased the risk of UGIB 14-fold (OR=14.46 [95% CI: 6.08 to 34.40]). This interaction was additive, with a synergistic index of 3.01 (95% CI: 1.18-7.71). CONCLUSIONS: Prior Anisakis infection is an independent risk factor for UGIB, and the joint effect with NSAIDs is 3 times higher than the sum of their individual effects. |
format |
Article in Journal/Newspaper |
author |
Florencio M Ubeira Ana M Anadón Angel Salgado Alfonso Carvajal Sara Ortega Carmelo Aguirre María José López-Goikoetxea Luisa Ibanez Adolfo Figueiras |
author_facet |
Florencio M Ubeira Ana M Anadón Angel Salgado Alfonso Carvajal Sara Ortega Carmelo Aguirre María José López-Goikoetxea Luisa Ibanez Adolfo Figueiras |
author_sort |
Florencio M Ubeira |
title |
Synergism between prior Anisakis simplex infections and intake of NSAIDs, on the risk of upper digestive bleeding: a case-control study. |
title_short |
Synergism between prior Anisakis simplex infections and intake of NSAIDs, on the risk of upper digestive bleeding: a case-control study. |
title_full |
Synergism between prior Anisakis simplex infections and intake of NSAIDs, on the risk of upper digestive bleeding: a case-control study. |
title_fullStr |
Synergism between prior Anisakis simplex infections and intake of NSAIDs, on the risk of upper digestive bleeding: a case-control study. |
title_full_unstemmed |
Synergism between prior Anisakis simplex infections and intake of NSAIDs, on the risk of upper digestive bleeding: a case-control study. |
title_sort |
synergism between prior anisakis simplex infections and intake of nsaids, on the risk of upper digestive bleeding: a case-control study. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2011 |
url |
https://doi.org/10.1371/journal.pntd.0001214 https://doaj.org/article/61927fe7951149debc1104ea7e8760ea |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 5, Iss 6, p e1214 (2011) |
op_relation |
http://europepmc.org/articles/PMC3125143?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0001214 https://doaj.org/article/61927fe7951149debc1104ea7e8760ea |
op_doi |
https://doi.org/10.1371/journal.pntd.0001214 |
container_title |
PLoS Neglected Tropical Diseases |
container_volume |
5 |
container_issue |
6 |
container_start_page |
e1214 |
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1766339813682708480 |