On the interference of clinical outcome on rabies transmission an perpetuation
Rabies is a viral zoonotic infectious disease that affects mammals and is caused by genotypes/species of the Lyssavirus genus (Rhabdoviridae, Mononegavirales), with the genotype 1 (classic rabies virus - RABV) being the most prevalent. Despite continuous efforts, rabies is still an incurable disease...
Published in: | Journal of Venomous Animals and Toxins including Tropical Diseases |
---|---|
Main Author: | |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
SciELO
2009
|
Subjects: | |
Online Access: | https://doi.org/10.1590/S1678-91992009000200003 https://doaj.org/article/6190c18f6c1943578db2cc483598291a |
id |
ftdoajarticles:oai:doaj.org/article:6190c18f6c1943578db2cc483598291a |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:6190c18f6c1943578db2cc483598291a 2023-05-15T15:07:46+02:00 On the interference of clinical outcome on rabies transmission an perpetuation PE Brandão 2009-01-01T00:00:00Z https://doi.org/10.1590/S1678-91992009000200003 https://doaj.org/article/6190c18f6c1943578db2cc483598291a EN eng SciELO http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992009000200003 https://doaj.org/toc/1678-9199 doi:10.1590/S1678-91992009000200003 1678-9199 https://doaj.org/article/6190c18f6c1943578db2cc483598291a Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 15, Iss 2, Pp 190-203 (2009) rabies transmission disease ecology epidemiology immune response Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 article 2009 ftdoajarticles https://doi.org/10.1590/S1678-91992009000200003 2022-12-31T05:11:10Z Rabies is a viral zoonotic infectious disease that affects mammals and is caused by genotypes/species of the Lyssavirus genus (Rhabdoviridae, Mononegavirales), with the genotype 1 (classic rabies virus - RABV) being the most prevalent. Despite continuous efforts, rabies is still an incurable disease that causes thousands of deaths amongst humans worldwide. Due to a wide range of hosts and the different evolutionary paths of RABV in each host, several host-specific variants have arisen in an ongoing process. The result of RABV replication in nervous tissues may lead to two opposite clinical outcomes, i.e., paralytic/dumb form and encephalitic/furious one. The paralytic form creates dead-end hosts mainly amongst herbivores, while the furious form of the disease allows for augmented transmission when manifested in gregarious carnivores, as their natural aggressive behavior is accentuated by the disease itself. The aim of this article is to propose a theoretical model intended to explore how the rabies virus intrinsically modulates the immune system of different host classes, the pathological changes that the virus causes in these animals and how these elements favor its own perpetuation in nature, thus providing a basis for better prediction of the patterns this disease may present. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Journal of Venomous Animals and Toxins including Tropical Diseases 15 2 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
rabies transmission disease ecology epidemiology immune response Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
spellingShingle |
rabies transmission disease ecology epidemiology immune response Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 PE Brandão On the interference of clinical outcome on rabies transmission an perpetuation |
topic_facet |
rabies transmission disease ecology epidemiology immune response Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
description |
Rabies is a viral zoonotic infectious disease that affects mammals and is caused by genotypes/species of the Lyssavirus genus (Rhabdoviridae, Mononegavirales), with the genotype 1 (classic rabies virus - RABV) being the most prevalent. Despite continuous efforts, rabies is still an incurable disease that causes thousands of deaths amongst humans worldwide. Due to a wide range of hosts and the different evolutionary paths of RABV in each host, several host-specific variants have arisen in an ongoing process. The result of RABV replication in nervous tissues may lead to two opposite clinical outcomes, i.e., paralytic/dumb form and encephalitic/furious one. The paralytic form creates dead-end hosts mainly amongst herbivores, while the furious form of the disease allows for augmented transmission when manifested in gregarious carnivores, as their natural aggressive behavior is accentuated by the disease itself. The aim of this article is to propose a theoretical model intended to explore how the rabies virus intrinsically modulates the immune system of different host classes, the pathological changes that the virus causes in these animals and how these elements favor its own perpetuation in nature, thus providing a basis for better prediction of the patterns this disease may present. |
format |
Article in Journal/Newspaper |
author |
PE Brandão |
author_facet |
PE Brandão |
author_sort |
PE Brandão |
title |
On the interference of clinical outcome on rabies transmission an perpetuation |
title_short |
On the interference of clinical outcome on rabies transmission an perpetuation |
title_full |
On the interference of clinical outcome on rabies transmission an perpetuation |
title_fullStr |
On the interference of clinical outcome on rabies transmission an perpetuation |
title_full_unstemmed |
On the interference of clinical outcome on rabies transmission an perpetuation |
title_sort |
on the interference of clinical outcome on rabies transmission an perpetuation |
publisher |
SciELO |
publishDate |
2009 |
url |
https://doi.org/10.1590/S1678-91992009000200003 https://doaj.org/article/6190c18f6c1943578db2cc483598291a |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 15, Iss 2, Pp 190-203 (2009) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992009000200003 https://doaj.org/toc/1678-9199 doi:10.1590/S1678-91992009000200003 1678-9199 https://doaj.org/article/6190c18f6c1943578db2cc483598291a |
op_doi |
https://doi.org/10.1590/S1678-91992009000200003 |
container_title |
Journal of Venomous Animals and Toxins including Tropical Diseases |
container_volume |
15 |
container_issue |
2 |
_version_ |
1766339195527233536 |