Cytokine profile and clinical metabolic alterations in HIV-1 infected individuals with and without lipodistrophy
The extensive use of Highly Active Antiretroviral Therapy (HAART) has transformed HIV infection into a chronic condition. Thus, metabolic alterations including lipodystrophy and dyslipidemia have been associated with the use of such medications. The objective of the present study was to analyze clin...
Published in: | Journal of Venomous Animals and Toxins including Tropical Diseases |
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ftdoajarticles:oai:doaj.org/article:615f05cb303d4ff89b40126c85dfbfca 2023-05-15T15:08:12+02:00 Cytokine profile and clinical metabolic alterations in HIV-1 infected individuals with and without lipodistrophy L. C. R. Pontes-Cardoso L. R. Souza M. T. S. Peraçoli P. C. M. Pereira 2007-01-01T00:00:00Z https://doi.org/10.1590/S1678-91992007000200009 https://doaj.org/article/615f05cb303d4ff89b40126c85dfbfca EN eng SciELO http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992007000200009 https://doaj.org/toc/1678-9199 doi:10.1590/S1678-91992007000200009 1678-9199 https://doaj.org/article/615f05cb303d4ff89b40126c85dfbfca Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 13, Iss 2, Pp 509-526 (2007) lipodystrophy HIV-1 hypertriglyceridemia cytokines Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 article 2007 ftdoajarticles https://doi.org/10.1590/S1678-91992007000200009 2022-12-31T00:58:29Z The extensive use of Highly Active Antiretroviral Therapy (HAART) has transformed HIV infection into a chronic condition. Thus, metabolic alterations including lipodystrophy and dyslipidemia have been associated with the use of such medications. The objective of the present study was to analyze clinical metabolic alterations and the profile of TNF-alpha, IFN-Y, IL-2, IL-10, and TNF-alpha type II soluble receptor in serum of HIV-1 individuals with and without lipodystrophy. Eighty-four adults were evaluated, 42 males and 42 females, mean age 37 years, and HAART time of at least 15 months. Two groups were formed, G1: 42 individuals with lipodystrophy, and G2: 42 without lipodistropy. From the HAART used, stavudine was more associated with the lipodystrophy group and zidovudine with the non-lipodystrophy group. CD4 and CD8 values, viral load, glucose, albumin, and lipids were not different between groups, except for triglycerides, which were high in the lipodystrophy group, and HDL, whose concentration was reduced in G1. TNF-alpha, TNF-RII, and IL-10 profiles were high and had positive correlation; IL-2 and IFN-gamma had reduced levels in the lipodystrophy group. High TNF-alpha and its receptor levels seem to be associated with lipodystrophy development in individuals under HAART therapy. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Journal of Venomous Animals and Toxins including Tropical Diseases 13 2 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
lipodystrophy HIV-1 hypertriglyceridemia cytokines Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
spellingShingle |
lipodystrophy HIV-1 hypertriglyceridemia cytokines Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 L. C. R. Pontes-Cardoso L. R. Souza M. T. S. Peraçoli P. C. M. Pereira Cytokine profile and clinical metabolic alterations in HIV-1 infected individuals with and without lipodistrophy |
topic_facet |
lipodystrophy HIV-1 hypertriglyceridemia cytokines Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
description |
The extensive use of Highly Active Antiretroviral Therapy (HAART) has transformed HIV infection into a chronic condition. Thus, metabolic alterations including lipodystrophy and dyslipidemia have been associated with the use of such medications. The objective of the present study was to analyze clinical metabolic alterations and the profile of TNF-alpha, IFN-Y, IL-2, IL-10, and TNF-alpha type II soluble receptor in serum of HIV-1 individuals with and without lipodystrophy. Eighty-four adults were evaluated, 42 males and 42 females, mean age 37 years, and HAART time of at least 15 months. Two groups were formed, G1: 42 individuals with lipodystrophy, and G2: 42 without lipodistropy. From the HAART used, stavudine was more associated with the lipodystrophy group and zidovudine with the non-lipodystrophy group. CD4 and CD8 values, viral load, glucose, albumin, and lipids were not different between groups, except for triglycerides, which were high in the lipodystrophy group, and HDL, whose concentration was reduced in G1. TNF-alpha, TNF-RII, and IL-10 profiles were high and had positive correlation; IL-2 and IFN-gamma had reduced levels in the lipodystrophy group. High TNF-alpha and its receptor levels seem to be associated with lipodystrophy development in individuals under HAART therapy. |
format |
Article in Journal/Newspaper |
author |
L. C. R. Pontes-Cardoso L. R. Souza M. T. S. Peraçoli P. C. M. Pereira |
author_facet |
L. C. R. Pontes-Cardoso L. R. Souza M. T. S. Peraçoli P. C. M. Pereira |
author_sort |
L. C. R. Pontes-Cardoso |
title |
Cytokine profile and clinical metabolic alterations in HIV-1 infected individuals with and without lipodistrophy |
title_short |
Cytokine profile and clinical metabolic alterations in HIV-1 infected individuals with and without lipodistrophy |
title_full |
Cytokine profile and clinical metabolic alterations in HIV-1 infected individuals with and without lipodistrophy |
title_fullStr |
Cytokine profile and clinical metabolic alterations in HIV-1 infected individuals with and without lipodistrophy |
title_full_unstemmed |
Cytokine profile and clinical metabolic alterations in HIV-1 infected individuals with and without lipodistrophy |
title_sort |
cytokine profile and clinical metabolic alterations in hiv-1 infected individuals with and without lipodistrophy |
publisher |
SciELO |
publishDate |
2007 |
url |
https://doi.org/10.1590/S1678-91992007000200009 https://doaj.org/article/615f05cb303d4ff89b40126c85dfbfca |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 13, Iss 2, Pp 509-526 (2007) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992007000200009 https://doaj.org/toc/1678-9199 doi:10.1590/S1678-91992007000200009 1678-9199 https://doaj.org/article/615f05cb303d4ff89b40126c85dfbfca |
op_doi |
https://doi.org/10.1590/S1678-91992007000200009 |
container_title |
Journal of Venomous Animals and Toxins including Tropical Diseases |
container_volume |
13 |
container_issue |
2 |
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1766339607490723840 |