Performance of cryptococcal antigen lateral flow assay in serum, cerebrospinal fluid, whole blood, and urine in HIV-infected patients with culture-proven cryptococcal meningitis admitted at a Brazilian referral center
ABSTRACT Cryptococcal meningitis is the most common cause of opportunistic meningitis in HIV-infected patients in Brazil and causes unacceptable high mortality rates. In this study, HIV-infected patients with a first episode of culture-proven cryptococcal meningitis in cerebrospinal fluid (CSF) were...
Published in: | Revista do Instituto de Medicina Tropical de São Paulo |
---|---|
Main Authors: | , , , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Universidade de São Paulo (USP)
2018
|
Subjects: | |
Online Access: | https://doi.org/10.1590/s1678-9946201860001 https://doaj.org/article/6148cd00776b4013bc03915b74e4d075 |
id |
ftdoajarticles:oai:doaj.org/article:6148cd00776b4013bc03915b74e4d075 |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:6148cd00776b4013bc03915b74e4d075 2024-09-09T19:26:24+00:00 Performance of cryptococcal antigen lateral flow assay in serum, cerebrospinal fluid, whole blood, and urine in HIV-infected patients with culture-proven cryptococcal meningitis admitted at a Brazilian referral center José E. Vidal Carolina Toniolo Adriana Paulino Arnaldo L. Colombo Marilena dos Anjos Martins Cristina da Silva Meira Renata Guise Soares Azevedo Vera Lucia Pereira-Chioccola Hélio Rodrigues Gomes Marcia dos Santos Lazera Augusto C. Penalva de Oliveira David R. Boulware 2018-02-01T00:00:00Z https://doi.org/10.1590/s1678-9946201860001 https://doaj.org/article/6148cd00776b4013bc03915b74e4d075 EN eng Universidade de São Paulo (USP) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652018005000600&lng=en&tlng=en https://doaj.org/toc/1678-9946 1678-9946 doi:10.1590/s1678-9946201860001 https://doaj.org/article/6148cd00776b4013bc03915b74e4d075 Revista do Instituto de Medicina Tropical de São Paulo, Vol 60, Iss 0 (2018) Cryptococcal meningitis Cryptococcosis Diagnosis Human immunodeficiency virus Acquired immunodeficiency syndrome Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2018 ftdoajarticles https://doi.org/10.1590/s1678-9946201860001 2024-08-05T17:49:31Z ABSTRACT Cryptococcal meningitis is the most common cause of opportunistic meningitis in HIV-infected patients in Brazil and causes unacceptable high mortality rates. In this study, HIV-infected patients with a first episode of culture-proven cryptococcal meningitis in cerebrospinal fluid (CSF) were prospectively included in order to evaluate sensitivity of cryptococcal antigen (CrAg) lateral flow assay (LFA) in serum, CSF, whole blood (fingerstick), and fresh urine. In addition, HIV-infected patients with other neurological confirmed diseases were included in order to evaluate the specificity of CrAg LFA in serum. Twenty patients with cryptococcal meningitis were included and in 19 of them, CrAg LFA in CSF, serum, and whole blood were positive (95% sensitivity). In 18 patients, India ink test was positive in CSF (90% sensitivity), and in 16 cases, CrAg LFA was positive in urine (80% sensitivity). Thirty-six HIV-infected patients with other neurological diseases had negative results of CrAg LFA in serum (100% specificity). In conclusion, CrAg LFA in serum, CSF, and whole blood showed high sensitivity and specificity. Whole blood CrAg LFA seems to be a good and reliable strategy to improve AIDS-related cryptococcal meningitis diagnosis in Brazil. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista do Instituto de Medicina Tropical de São Paulo 60 0 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Cryptococcal meningitis Cryptococcosis Diagnosis Human immunodeficiency virus Acquired immunodeficiency syndrome Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Cryptococcal meningitis Cryptococcosis Diagnosis Human immunodeficiency virus Acquired immunodeficiency syndrome Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 José E. Vidal Carolina Toniolo Adriana Paulino Arnaldo L. Colombo Marilena dos Anjos Martins Cristina da Silva Meira Renata Guise Soares Azevedo Vera Lucia Pereira-Chioccola Hélio Rodrigues Gomes Marcia dos Santos Lazera Augusto C. Penalva de Oliveira David R. Boulware Performance of cryptococcal antigen lateral flow assay in serum, cerebrospinal fluid, whole blood, and urine in HIV-infected patients with culture-proven cryptococcal meningitis admitted at a Brazilian referral center |
topic_facet |
Cryptococcal meningitis Cryptococcosis Diagnosis Human immunodeficiency virus Acquired immunodeficiency syndrome Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
ABSTRACT Cryptococcal meningitis is the most common cause of opportunistic meningitis in HIV-infected patients in Brazil and causes unacceptable high mortality rates. In this study, HIV-infected patients with a first episode of culture-proven cryptococcal meningitis in cerebrospinal fluid (CSF) were prospectively included in order to evaluate sensitivity of cryptococcal antigen (CrAg) lateral flow assay (LFA) in serum, CSF, whole blood (fingerstick), and fresh urine. In addition, HIV-infected patients with other neurological confirmed diseases were included in order to evaluate the specificity of CrAg LFA in serum. Twenty patients with cryptococcal meningitis were included and in 19 of them, CrAg LFA in CSF, serum, and whole blood were positive (95% sensitivity). In 18 patients, India ink test was positive in CSF (90% sensitivity), and in 16 cases, CrAg LFA was positive in urine (80% sensitivity). Thirty-six HIV-infected patients with other neurological diseases had negative results of CrAg LFA in serum (100% specificity). In conclusion, CrAg LFA in serum, CSF, and whole blood showed high sensitivity and specificity. Whole blood CrAg LFA seems to be a good and reliable strategy to improve AIDS-related cryptococcal meningitis diagnosis in Brazil. |
format |
Article in Journal/Newspaper |
author |
José E. Vidal Carolina Toniolo Adriana Paulino Arnaldo L. Colombo Marilena dos Anjos Martins Cristina da Silva Meira Renata Guise Soares Azevedo Vera Lucia Pereira-Chioccola Hélio Rodrigues Gomes Marcia dos Santos Lazera Augusto C. Penalva de Oliveira David R. Boulware |
author_facet |
José E. Vidal Carolina Toniolo Adriana Paulino Arnaldo L. Colombo Marilena dos Anjos Martins Cristina da Silva Meira Renata Guise Soares Azevedo Vera Lucia Pereira-Chioccola Hélio Rodrigues Gomes Marcia dos Santos Lazera Augusto C. Penalva de Oliveira David R. Boulware |
author_sort |
José E. Vidal |
title |
Performance of cryptococcal antigen lateral flow assay in serum, cerebrospinal fluid, whole blood, and urine in HIV-infected patients with culture-proven cryptococcal meningitis admitted at a Brazilian referral center |
title_short |
Performance of cryptococcal antigen lateral flow assay in serum, cerebrospinal fluid, whole blood, and urine in HIV-infected patients with culture-proven cryptococcal meningitis admitted at a Brazilian referral center |
title_full |
Performance of cryptococcal antigen lateral flow assay in serum, cerebrospinal fluid, whole blood, and urine in HIV-infected patients with culture-proven cryptococcal meningitis admitted at a Brazilian referral center |
title_fullStr |
Performance of cryptococcal antigen lateral flow assay in serum, cerebrospinal fluid, whole blood, and urine in HIV-infected patients with culture-proven cryptococcal meningitis admitted at a Brazilian referral center |
title_full_unstemmed |
Performance of cryptococcal antigen lateral flow assay in serum, cerebrospinal fluid, whole blood, and urine in HIV-infected patients with culture-proven cryptococcal meningitis admitted at a Brazilian referral center |
title_sort |
performance of cryptococcal antigen lateral flow assay in serum, cerebrospinal fluid, whole blood, and urine in hiv-infected patients with culture-proven cryptococcal meningitis admitted at a brazilian referral center |
publisher |
Universidade de São Paulo (USP) |
publishDate |
2018 |
url |
https://doi.org/10.1590/s1678-9946201860001 https://doaj.org/article/6148cd00776b4013bc03915b74e4d075 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista do Instituto de Medicina Tropical de São Paulo, Vol 60, Iss 0 (2018) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652018005000600&lng=en&tlng=en https://doaj.org/toc/1678-9946 1678-9946 doi:10.1590/s1678-9946201860001 https://doaj.org/article/6148cd00776b4013bc03915b74e4d075 |
op_doi |
https://doi.org/10.1590/s1678-9946201860001 |
container_title |
Revista do Instituto de Medicina Tropical de São Paulo |
container_volume |
60 |
container_issue |
0 |
_version_ |
1809896017921835008 |