Effectiveness of routine BCG vaccination on buruli ulcer disease: a case-control study in the Democratic Republic of Congo, Ghana and Togo.
The only available vaccine that could be potentially beneficial against mycobacterial diseases contains live attenuated bovine tuberculosis bacillus (Mycobacterium bovis) also called Bacillus Calmette-Guérin (BCG). Even though the BCG vaccine is still widely used, results on its effectiveness in pre...
Published in: | PLoS Neglected Tropical Diseases |
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ftdoajarticles:oai:doaj.org/article:611e70905af648808a6a17f41ea4dba9 2023-05-15T15:15:00+02:00 Effectiveness of routine BCG vaccination on buruli ulcer disease: a case-control study in the Democratic Republic of Congo, Ghana and Togo. Richard Odame Phillips Delphin Mavinga Phanzu Marcus Beissner Kossi Badziklou Elysée Kalundieko Luzolo Fred Stephen Sarfo Wemboo Afiwa Halatoko Yaw Amoako Michael Frimpong Abass Mohammed Kabiru Ebekalisai Piten Issaka Maman Bawimodom Bidjada Adjaho Koba Koffi Somenou Awoussi Basile Kobara Jörg Nitschke Franz Xaver Wiedemann Abiba Banla Kere Ohene Adjei Thomas Löscher Bernhard Fleischer Gisela Bretzel Karl-Heinz Herbinger 2015-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0003457 https://doaj.org/article/611e70905af648808a6a17f41ea4dba9 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC4287572?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0003457 https://doaj.org/article/611e70905af648808a6a17f41ea4dba9 PLoS Neglected Tropical Diseases, Vol 9, Iss 1, p e3457 (2015) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2015 ftdoajarticles https://doi.org/10.1371/journal.pntd.0003457 2022-12-31T10:25:00Z The only available vaccine that could be potentially beneficial against mycobacterial diseases contains live attenuated bovine tuberculosis bacillus (Mycobacterium bovis) also called Bacillus Calmette-Guérin (BCG). Even though the BCG vaccine is still widely used, results on its effectiveness in preventing mycobacterial diseases are partially contradictory, especially regarding Buruli Ulcer Disease (BUD). The aim of this case-control study is to evaluate the possible protective effect of BCG vaccination on BUD.The present study was performed in three different countries and sites where BUD is endemic: in the Democratic Republic of the Congo, Ghana, and Togo from 2010 through 2013. The large study population was comprised of 401 cases with laboratory confirmed BUD and 826 controls, mostly family members or neighbors.After stratification by the three countries, two sexes and four age groups, no significant correlation was found between the presence of BCG scar and BUD status of individuals. Multivariate analysis has shown that the independent variables country (p = 0.31), sex (p = 0.24), age (p = 0.96), and presence of a BCG scar (p = 0.07) did not significantly influence the development of BUD category I or category II/III. Furthermore, the status of BCG vaccination was also not significantly related to duration of BUD or time to healing of lesions.In our study, we did not observe significant evidence of a protective effect of routine BCG vaccination on the risk of developing either BUD or severe forms of BUD. Since accurate data on BCG strains used in these three countries were not available, no final conclusion can be drawn on the effectiveness of BCG strain in protecting against BUD. As has been suggested for tuberculosis and leprosy, well-designed prospective studies on different existing BCG vaccine strains are needed also for BUD. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Calmette ENVELOPE(-67.150,-67.150,-68.050,-68.050) PLoS Neglected Tropical Diseases 9 1 e3457 |
institution |
Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Richard Odame Phillips Delphin Mavinga Phanzu Marcus Beissner Kossi Badziklou Elysée Kalundieko Luzolo Fred Stephen Sarfo Wemboo Afiwa Halatoko Yaw Amoako Michael Frimpong Abass Mohammed Kabiru Ebekalisai Piten Issaka Maman Bawimodom Bidjada Adjaho Koba Koffi Somenou Awoussi Basile Kobara Jörg Nitschke Franz Xaver Wiedemann Abiba Banla Kere Ohene Adjei Thomas Löscher Bernhard Fleischer Gisela Bretzel Karl-Heinz Herbinger Effectiveness of routine BCG vaccination on buruli ulcer disease: a case-control study in the Democratic Republic of Congo, Ghana and Togo. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
The only available vaccine that could be potentially beneficial against mycobacterial diseases contains live attenuated bovine tuberculosis bacillus (Mycobacterium bovis) also called Bacillus Calmette-Guérin (BCG). Even though the BCG vaccine is still widely used, results on its effectiveness in preventing mycobacterial diseases are partially contradictory, especially regarding Buruli Ulcer Disease (BUD). The aim of this case-control study is to evaluate the possible protective effect of BCG vaccination on BUD.The present study was performed in three different countries and sites where BUD is endemic: in the Democratic Republic of the Congo, Ghana, and Togo from 2010 through 2013. The large study population was comprised of 401 cases with laboratory confirmed BUD and 826 controls, mostly family members or neighbors.After stratification by the three countries, two sexes and four age groups, no significant correlation was found between the presence of BCG scar and BUD status of individuals. Multivariate analysis has shown that the independent variables country (p = 0.31), sex (p = 0.24), age (p = 0.96), and presence of a BCG scar (p = 0.07) did not significantly influence the development of BUD category I or category II/III. Furthermore, the status of BCG vaccination was also not significantly related to duration of BUD or time to healing of lesions.In our study, we did not observe significant evidence of a protective effect of routine BCG vaccination on the risk of developing either BUD or severe forms of BUD. Since accurate data on BCG strains used in these three countries were not available, no final conclusion can be drawn on the effectiveness of BCG strain in protecting against BUD. As has been suggested for tuberculosis and leprosy, well-designed prospective studies on different existing BCG vaccine strains are needed also for BUD. |
format |
Article in Journal/Newspaper |
author |
Richard Odame Phillips Delphin Mavinga Phanzu Marcus Beissner Kossi Badziklou Elysée Kalundieko Luzolo Fred Stephen Sarfo Wemboo Afiwa Halatoko Yaw Amoako Michael Frimpong Abass Mohammed Kabiru Ebekalisai Piten Issaka Maman Bawimodom Bidjada Adjaho Koba Koffi Somenou Awoussi Basile Kobara Jörg Nitschke Franz Xaver Wiedemann Abiba Banla Kere Ohene Adjei Thomas Löscher Bernhard Fleischer Gisela Bretzel Karl-Heinz Herbinger |
author_facet |
Richard Odame Phillips Delphin Mavinga Phanzu Marcus Beissner Kossi Badziklou Elysée Kalundieko Luzolo Fred Stephen Sarfo Wemboo Afiwa Halatoko Yaw Amoako Michael Frimpong Abass Mohammed Kabiru Ebekalisai Piten Issaka Maman Bawimodom Bidjada Adjaho Koba Koffi Somenou Awoussi Basile Kobara Jörg Nitschke Franz Xaver Wiedemann Abiba Banla Kere Ohene Adjei Thomas Löscher Bernhard Fleischer Gisela Bretzel Karl-Heinz Herbinger |
author_sort |
Richard Odame Phillips |
title |
Effectiveness of routine BCG vaccination on buruli ulcer disease: a case-control study in the Democratic Republic of Congo, Ghana and Togo. |
title_short |
Effectiveness of routine BCG vaccination on buruli ulcer disease: a case-control study in the Democratic Republic of Congo, Ghana and Togo. |
title_full |
Effectiveness of routine BCG vaccination on buruli ulcer disease: a case-control study in the Democratic Republic of Congo, Ghana and Togo. |
title_fullStr |
Effectiveness of routine BCG vaccination on buruli ulcer disease: a case-control study in the Democratic Republic of Congo, Ghana and Togo. |
title_full_unstemmed |
Effectiveness of routine BCG vaccination on buruli ulcer disease: a case-control study in the Democratic Republic of Congo, Ghana and Togo. |
title_sort |
effectiveness of routine bcg vaccination on buruli ulcer disease: a case-control study in the democratic republic of congo, ghana and togo. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2015 |
url |
https://doi.org/10.1371/journal.pntd.0003457 https://doaj.org/article/611e70905af648808a6a17f41ea4dba9 |
long_lat |
ENVELOPE(-67.150,-67.150,-68.050,-68.050) |
geographic |
Arctic Calmette |
geographic_facet |
Arctic Calmette |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 9, Iss 1, p e3457 (2015) |
op_relation |
http://europepmc.org/articles/PMC4287572?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0003457 https://doaj.org/article/611e70905af648808a6a17f41ea4dba9 |
op_doi |
https://doi.org/10.1371/journal.pntd.0003457 |
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PLoS Neglected Tropical Diseases |
container_volume |
9 |
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1 |
container_start_page |
e3457 |
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