Intergenerational effects of early life-stage temperature modulation on gene expression and DNA methylation in Atlantic cod (Gadus morhua)

• Published in: Epigenetics
• Main Authors: Velmurugu Puvanendran, Erik Burgerhout, Øivind Andersen, Matthew Kent, Øyvind Hansen, Torstein Tengs
• Format: Article in Journal/Newspaper
• Language: English
• Published: Taylor & Francis Group 2023
• Subjects: atlantic cod; epigenetics; temperature; aquaculture; intergenerational; Genetics; QH426-470; Gadus morhua
• Online Access: https://doi.org/10.1080/15592294.2023.2237759; https://doaj.org/article/610f30bcfffb4ce8a6ecefcb197701be

After suffering several collapses, the cod farming industry is now in the process of trying to re-establish itself. We have used material from Norway’s National Cod Breeding Program to study how different early life-stage temperature regimes affect DNA methylation and gene expression. Long-term effects were detected by sampling fish several weeks after the end of differential treatments, and offspring from the different exposure groups was also sampled. Many overlapping genes were found between the different exposure groups and generations, coupled with genes associated with differential CpG methylation levels. Genes involved in muscle fibre development, general metabolic processes and formation of deformities were significantly affected, and genes relevant for intergenerational transfer of epigenetic marks were also detected. We believe the use of environmental cues can be a useful strategy for improving the production of Atlantic cod.