The impact of low erythrocyte density in human blood on the fitness and energetic reserves of the African malaria vector Anopheles gambiae
Abstract Background Anaemia is a common health problem in the developing world. This condition is characterized by a reduction in erythrocyte density, primarily from malnutrition and/or infectious diseases such as malaria. As red blood cells are the primary source of protein for haematophagous mosqu...
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ftdoajarticles:oai:doaj.org/article:6100ec01d517458db82a3266eb96de50 2023-05-15T15:18:03+02:00 The impact of low erythrocyte density in human blood on the fitness and energetic reserves of the African malaria vector Anopheles gambiae Emami S Noushin Ranford-Cartwright Lisa C Ferguson Heather M 2013-02-01T00:00:00Z https://doi.org/10.1186/1475-2875-12-45 https://doaj.org/article/6100ec01d517458db82a3266eb96de50 EN eng BMC http://www.malariajournal.com/content/12/1/45 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-12-45 1475-2875 https://doaj.org/article/6100ec01d517458db82a3266eb96de50 Malaria Journal, Vol 12, Iss 1, p 45 (2013) Malaria Anopheles gambiae Mosquito vector Erythrocyte density Fitness Energetic reserves Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2013 ftdoajarticles https://doi.org/10.1186/1475-2875-12-45 2022-12-31T09:32:22Z Abstract Background Anaemia is a common health problem in the developing world. This condition is characterized by a reduction in erythrocyte density, primarily from malnutrition and/or infectious diseases such as malaria. As red blood cells are the primary source of protein for haematophagous mosquitoes, any reduction could impede the ability of mosquito vectors to transmit malaria by influencing their fitness or that of the parasites they transmit. The aim of this study was to determine the impact of differences in the density of red blood cells in human blood on malaria vector ( Anopheles gambiae sensu stricto) fitness. The hypotheses tested are that mosquito vector energetic reserves and fitness are negatively influenced by reductions in the red cell density of host human blood meals commensurate with those expected from severe anaemia. Methods Mosquitoes ( An. gambiae s.s. ) were offered blood meals of different packed cell volume (PCV) of human blood consistent with those arising from severe anaemia (15%) and normal PCV (50%). Associations between mosquito energetic reserves (lipid, glucose and glycogen) and fitness measures (reproduction and survival) and blood meal PCV were investigated. Results The amount of protein that malaria vectors acquired from blood feeding (indexed by haematin excretion) was significantly reduced at low blood PCV. However, mosquitoes feeding on blood of low PCV had the same oviposition rates as those feeding on blood of normal PCV, and showed an increase in egg production of around 15%. The long-term survival of An. gambiae s.s was reduced after feeding on low PCV blood, but PCV had no significant impact on the proportion of mosquitoes surviving through the minimal period required to develop and transmit malaria parasites (estimated as 14 days post-blood feeding). The impact of blood PCV on the energetic reserves of mosquitoes was relatively minor. Conclusions These results suggest that feeding on human hosts whose PCV has been depleted due to severe anaemia does not ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 12 1 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
topic |
Malaria Anopheles gambiae Mosquito vector Erythrocyte density Fitness Energetic reserves Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Malaria Anopheles gambiae Mosquito vector Erythrocyte density Fitness Energetic reserves Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Emami S Noushin Ranford-Cartwright Lisa C Ferguson Heather M The impact of low erythrocyte density in human blood on the fitness and energetic reserves of the African malaria vector Anopheles gambiae |
topic_facet |
Malaria Anopheles gambiae Mosquito vector Erythrocyte density Fitness Energetic reserves Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Anaemia is a common health problem in the developing world. This condition is characterized by a reduction in erythrocyte density, primarily from malnutrition and/or infectious diseases such as malaria. As red blood cells are the primary source of protein for haematophagous mosquitoes, any reduction could impede the ability of mosquito vectors to transmit malaria by influencing their fitness or that of the parasites they transmit. The aim of this study was to determine the impact of differences in the density of red blood cells in human blood on malaria vector ( Anopheles gambiae sensu stricto) fitness. The hypotheses tested are that mosquito vector energetic reserves and fitness are negatively influenced by reductions in the red cell density of host human blood meals commensurate with those expected from severe anaemia. Methods Mosquitoes ( An. gambiae s.s. ) were offered blood meals of different packed cell volume (PCV) of human blood consistent with those arising from severe anaemia (15%) and normal PCV (50%). Associations between mosquito energetic reserves (lipid, glucose and glycogen) and fitness measures (reproduction and survival) and blood meal PCV were investigated. Results The amount of protein that malaria vectors acquired from blood feeding (indexed by haematin excretion) was significantly reduced at low blood PCV. However, mosquitoes feeding on blood of low PCV had the same oviposition rates as those feeding on blood of normal PCV, and showed an increase in egg production of around 15%. The long-term survival of An. gambiae s.s was reduced after feeding on low PCV blood, but PCV had no significant impact on the proportion of mosquitoes surviving through the minimal period required to develop and transmit malaria parasites (estimated as 14 days post-blood feeding). The impact of blood PCV on the energetic reserves of mosquitoes was relatively minor. Conclusions These results suggest that feeding on human hosts whose PCV has been depleted due to severe anaemia does not ... |
format |
Article in Journal/Newspaper |
author |
Emami S Noushin Ranford-Cartwright Lisa C Ferguson Heather M |
author_facet |
Emami S Noushin Ranford-Cartwright Lisa C Ferguson Heather M |
author_sort |
Emami S Noushin |
title |
The impact of low erythrocyte density in human blood on the fitness and energetic reserves of the African malaria vector Anopheles gambiae |
title_short |
The impact of low erythrocyte density in human blood on the fitness and energetic reserves of the African malaria vector Anopheles gambiae |
title_full |
The impact of low erythrocyte density in human blood on the fitness and energetic reserves of the African malaria vector Anopheles gambiae |
title_fullStr |
The impact of low erythrocyte density in human blood on the fitness and energetic reserves of the African malaria vector Anopheles gambiae |
title_full_unstemmed |
The impact of low erythrocyte density in human blood on the fitness and energetic reserves of the African malaria vector Anopheles gambiae |
title_sort |
impact of low erythrocyte density in human blood on the fitness and energetic reserves of the african malaria vector anopheles gambiae |
publisher |
BMC |
publishDate |
2013 |
url |
https://doi.org/10.1186/1475-2875-12-45 https://doaj.org/article/6100ec01d517458db82a3266eb96de50 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 12, Iss 1, p 45 (2013) |
op_relation |
http://www.malariajournal.com/content/12/1/45 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-12-45 1475-2875 https://doaj.org/article/6100ec01d517458db82a3266eb96de50 |
op_doi |
https://doi.org/10.1186/1475-2875-12-45 |
container_title |
Malaria Journal |
container_volume |
12 |
container_issue |
1 |
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1766348286892965888 |