The Effect of Aqueous Extract of Cinnamon on the Metabolome of Plasmodium falciparum Using 1HNMR Spectroscopy
Malaria is responsible for estimated 584,000 deaths in 2013. Researchers are working on new drugs and medicinal herbs due to drug resistance that is a major problem facing them; the search is on for new medicinal herbs. Cinnamon is the bark of a tree with reported antiparasitic effects. Metabonomics...
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ftdoajarticles:oai:doaj.org/article:60fb1868f8a0488c9ea847a6974a1f80 2023-05-15T15:08:15+02:00 The Effect of Aqueous Extract of Cinnamon on the Metabolome of Plasmodium falciparum Using 1HNMR Spectroscopy Shirin Parvazi Sedigheh Sadeghi Mehri Azadi Maryam Mohammadi Mohammad Arjmand Farideh Vahabi Somye Sadeghzadeh Zahra Zamani 2016-01-01T00:00:00Z https://doi.org/10.1155/2016/3174841 https://doaj.org/article/60fb1868f8a0488c9ea847a6974a1f80 EN eng Hindawi Limited http://dx.doi.org/10.1155/2016/3174841 https://doaj.org/toc/1687-9686 https://doaj.org/toc/1687-9694 1687-9686 1687-9694 doi:10.1155/2016/3174841 https://doaj.org/article/60fb1868f8a0488c9ea847a6974a1f80 Journal of Tropical Medicine, Vol 2016 (2016) Arctic medicine. Tropical medicine RC955-962 article 2016 ftdoajarticles https://doi.org/10.1155/2016/3174841 2022-12-30T22:20:43Z Malaria is responsible for estimated 584,000 deaths in 2013. Researchers are working on new drugs and medicinal herbs due to drug resistance that is a major problem facing them; the search is on for new medicinal herbs. Cinnamon is the bark of a tree with reported antiparasitic effects. Metabonomics is the simultaneous study of all the metabolites in biological fluids, cells, and tissues detected by high throughput technology. It was decided to determine the mechanism of the effect of aqueous extract of cinnamon on the metabolome of Plasmodium falciparum in vitro using 1HNMR spectroscopy. Prepared aqueous extract of cinnamon was added to a culture of Plasmodium falciparum 3D7 and its 50% inhibitory concentration determined, and, after collection, their metabolites were extracted and 1HNMR spectroscopy by NOESY method was done. The spectra were analyzed by chemometric methods. The differentiating metabolites were identified using Human Metabolome Database and the metabolic cycles identified by Metaboanalyst. 50% inhibitory concentration of cinnamon on Plasmodium falciparum was 1.25 mg/mL with p<0.001. The metabolites were identified as succinic acid, glutathione, L-aspartic acid, beta-alanine, and 2-methylbutyryl glycine. The main metabolic cycles detected were alanine and aspartame and glutamate pathway and pantothenate and coenzyme A biosynthesis and lysine biosynthesis and glutathione metabolism, which are all important as drug targets. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Journal of Tropical Medicine 2016 1 5 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 |
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Arctic medicine. Tropical medicine RC955-962 Shirin Parvazi Sedigheh Sadeghi Mehri Azadi Maryam Mohammadi Mohammad Arjmand Farideh Vahabi Somye Sadeghzadeh Zahra Zamani The Effect of Aqueous Extract of Cinnamon on the Metabolome of Plasmodium falciparum Using 1HNMR Spectroscopy |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 |
description |
Malaria is responsible for estimated 584,000 deaths in 2013. Researchers are working on new drugs and medicinal herbs due to drug resistance that is a major problem facing them; the search is on for new medicinal herbs. Cinnamon is the bark of a tree with reported antiparasitic effects. Metabonomics is the simultaneous study of all the metabolites in biological fluids, cells, and tissues detected by high throughput technology. It was decided to determine the mechanism of the effect of aqueous extract of cinnamon on the metabolome of Plasmodium falciparum in vitro using 1HNMR spectroscopy. Prepared aqueous extract of cinnamon was added to a culture of Plasmodium falciparum 3D7 and its 50% inhibitory concentration determined, and, after collection, their metabolites were extracted and 1HNMR spectroscopy by NOESY method was done. The spectra were analyzed by chemometric methods. The differentiating metabolites were identified using Human Metabolome Database and the metabolic cycles identified by Metaboanalyst. 50% inhibitory concentration of cinnamon on Plasmodium falciparum was 1.25 mg/mL with p<0.001. The metabolites were identified as succinic acid, glutathione, L-aspartic acid, beta-alanine, and 2-methylbutyryl glycine. The main metabolic cycles detected were alanine and aspartame and glutamate pathway and pantothenate and coenzyme A biosynthesis and lysine biosynthesis and glutathione metabolism, which are all important as drug targets. |
format |
Article in Journal/Newspaper |
author |
Shirin Parvazi Sedigheh Sadeghi Mehri Azadi Maryam Mohammadi Mohammad Arjmand Farideh Vahabi Somye Sadeghzadeh Zahra Zamani |
author_facet |
Shirin Parvazi Sedigheh Sadeghi Mehri Azadi Maryam Mohammadi Mohammad Arjmand Farideh Vahabi Somye Sadeghzadeh Zahra Zamani |
author_sort |
Shirin Parvazi |
title |
The Effect of Aqueous Extract of Cinnamon on the Metabolome of Plasmodium falciparum Using 1HNMR Spectroscopy |
title_short |
The Effect of Aqueous Extract of Cinnamon on the Metabolome of Plasmodium falciparum Using 1HNMR Spectroscopy |
title_full |
The Effect of Aqueous Extract of Cinnamon on the Metabolome of Plasmodium falciparum Using 1HNMR Spectroscopy |
title_fullStr |
The Effect of Aqueous Extract of Cinnamon on the Metabolome of Plasmodium falciparum Using 1HNMR Spectroscopy |
title_full_unstemmed |
The Effect of Aqueous Extract of Cinnamon on the Metabolome of Plasmodium falciparum Using 1HNMR Spectroscopy |
title_sort |
effect of aqueous extract of cinnamon on the metabolome of plasmodium falciparum using 1hnmr spectroscopy |
publisher |
Hindawi Limited |
publishDate |
2016 |
url |
https://doi.org/10.1155/2016/3174841 https://doaj.org/article/60fb1868f8a0488c9ea847a6974a1f80 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Tropical Medicine, Vol 2016 (2016) |
op_relation |
http://dx.doi.org/10.1155/2016/3174841 https://doaj.org/toc/1687-9686 https://doaj.org/toc/1687-9694 1687-9686 1687-9694 doi:10.1155/2016/3174841 https://doaj.org/article/60fb1868f8a0488c9ea847a6974a1f80 |
op_doi |
https://doi.org/10.1155/2016/3174841 |
container_title |
Journal of Tropical Medicine |
container_volume |
2016 |
container_start_page |
1 |
op_container_end_page |
5 |
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1766339647975194624 |