Insulin-Like Peptide Receptor-Mediated Signaling Pathways Orchestrate Regulation of Growth in the Pacific Oyster ( Crassostrea gigas ), as Revealed by Gene Expression Profiles
The involvement of insulin/insulin-like growth factor signaling (IIS) pathways in the growth regulation of marine invertebrates remains largely unexplored. In this study, we used a fast-growing Pacific oyster ( Crassostrea gigas ) variety “Haida No.1” as the material with which to unravel the role o...
Published in: | International Journal of Molecular Sciences |
---|---|
Main Authors: | , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
MDPI AG
2021
|
Subjects: | |
Online Access: | https://doi.org/10.3390/ijms22105259 https://doaj.org/article/60c1a4df92644ff5848c77905b48bf83 |
id |
ftdoajarticles:oai:doaj.org/article:60c1a4df92644ff5848c77905b48bf83 |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:60c1a4df92644ff5848c77905b48bf83 2023-05-15T15:57:37+02:00 Insulin-Like Peptide Receptor-Mediated Signaling Pathways Orchestrate Regulation of Growth in the Pacific Oyster ( Crassostrea gigas ), as Revealed by Gene Expression Profiles Yongjing Li Huiru Fu Fuqiang Zhang Liting Ren Jing Tian Qi Li Shikai Liu 2021-05-01T00:00:00Z https://doi.org/10.3390/ijms22105259 https://doaj.org/article/60c1a4df92644ff5848c77905b48bf83 EN eng MDPI AG https://www.mdpi.com/1422-0067/22/10/5259 https://doaj.org/toc/1661-6596 https://doaj.org/toc/1422-0067 doi:10.3390/ijms22105259 1422-0067 1661-6596 https://doaj.org/article/60c1a4df92644ff5848c77905b48bf83 International Journal of Molecular Sciences, Vol 22, Iss 5259, p 5259 (2021) Crassostrea gigas IIS nutrient abundance temperature energy metabolism Biology (General) QH301-705.5 Chemistry QD1-999 article 2021 ftdoajarticles https://doi.org/10.3390/ijms22105259 2022-12-31T10:45:39Z The involvement of insulin/insulin-like growth factor signaling (IIS) pathways in the growth regulation of marine invertebrates remains largely unexplored. In this study, we used a fast-growing Pacific oyster ( Crassostrea gigas ) variety “Haida No.1” as the material with which to unravel the role of IIS systems in growth regulation in oysters. Systematic bioinformatics analyses allowed us to identify major components of the IIS signaling pathway and insulin-like peptide receptor (ILPR)-mediated signaling pathways, including PI3K-AKT, RAS-MAPK, and TOR, in C. gigas . The expression levels of the major genes in IIS and its downstream signaling pathways were significantly higher in “Haida No.1” than in wild oysters, suggesting their involvement in the growth regulation of C. gigas . The expression profiles of IIS and its downstream signaling pathway genes were significantly altered by nutrient abundance and culture temperature. These results suggest that the IIS signaling pathway coupled with the ILPR-mediated signaling pathways orchestrate the regulation of energy metabolism to control growth in Pacific oysters. Article in Journal/Newspaper Crassostrea gigas Pacific oyster Directory of Open Access Journals: DOAJ Articles Pacific International Journal of Molecular Sciences 22 10 5259 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Crassostrea gigas IIS nutrient abundance temperature energy metabolism Biology (General) QH301-705.5 Chemistry QD1-999 |
spellingShingle |
Crassostrea gigas IIS nutrient abundance temperature energy metabolism Biology (General) QH301-705.5 Chemistry QD1-999 Yongjing Li Huiru Fu Fuqiang Zhang Liting Ren Jing Tian Qi Li Shikai Liu Insulin-Like Peptide Receptor-Mediated Signaling Pathways Orchestrate Regulation of Growth in the Pacific Oyster ( Crassostrea gigas ), as Revealed by Gene Expression Profiles |
topic_facet |
Crassostrea gigas IIS nutrient abundance temperature energy metabolism Biology (General) QH301-705.5 Chemistry QD1-999 |
description |
The involvement of insulin/insulin-like growth factor signaling (IIS) pathways in the growth regulation of marine invertebrates remains largely unexplored. In this study, we used a fast-growing Pacific oyster ( Crassostrea gigas ) variety “Haida No.1” as the material with which to unravel the role of IIS systems in growth regulation in oysters. Systematic bioinformatics analyses allowed us to identify major components of the IIS signaling pathway and insulin-like peptide receptor (ILPR)-mediated signaling pathways, including PI3K-AKT, RAS-MAPK, and TOR, in C. gigas . The expression levels of the major genes in IIS and its downstream signaling pathways were significantly higher in “Haida No.1” than in wild oysters, suggesting their involvement in the growth regulation of C. gigas . The expression profiles of IIS and its downstream signaling pathway genes were significantly altered by nutrient abundance and culture temperature. These results suggest that the IIS signaling pathway coupled with the ILPR-mediated signaling pathways orchestrate the regulation of energy metabolism to control growth in Pacific oysters. |
format |
Article in Journal/Newspaper |
author |
Yongjing Li Huiru Fu Fuqiang Zhang Liting Ren Jing Tian Qi Li Shikai Liu |
author_facet |
Yongjing Li Huiru Fu Fuqiang Zhang Liting Ren Jing Tian Qi Li Shikai Liu |
author_sort |
Yongjing Li |
title |
Insulin-Like Peptide Receptor-Mediated Signaling Pathways Orchestrate Regulation of Growth in the Pacific Oyster ( Crassostrea gigas ), as Revealed by Gene Expression Profiles |
title_short |
Insulin-Like Peptide Receptor-Mediated Signaling Pathways Orchestrate Regulation of Growth in the Pacific Oyster ( Crassostrea gigas ), as Revealed by Gene Expression Profiles |
title_full |
Insulin-Like Peptide Receptor-Mediated Signaling Pathways Orchestrate Regulation of Growth in the Pacific Oyster ( Crassostrea gigas ), as Revealed by Gene Expression Profiles |
title_fullStr |
Insulin-Like Peptide Receptor-Mediated Signaling Pathways Orchestrate Regulation of Growth in the Pacific Oyster ( Crassostrea gigas ), as Revealed by Gene Expression Profiles |
title_full_unstemmed |
Insulin-Like Peptide Receptor-Mediated Signaling Pathways Orchestrate Regulation of Growth in the Pacific Oyster ( Crassostrea gigas ), as Revealed by Gene Expression Profiles |
title_sort |
insulin-like peptide receptor-mediated signaling pathways orchestrate regulation of growth in the pacific oyster ( crassostrea gigas ), as revealed by gene expression profiles |
publisher |
MDPI AG |
publishDate |
2021 |
url |
https://doi.org/10.3390/ijms22105259 https://doaj.org/article/60c1a4df92644ff5848c77905b48bf83 |
geographic |
Pacific |
geographic_facet |
Pacific |
genre |
Crassostrea gigas Pacific oyster |
genre_facet |
Crassostrea gigas Pacific oyster |
op_source |
International Journal of Molecular Sciences, Vol 22, Iss 5259, p 5259 (2021) |
op_relation |
https://www.mdpi.com/1422-0067/22/10/5259 https://doaj.org/toc/1661-6596 https://doaj.org/toc/1422-0067 doi:10.3390/ijms22105259 1422-0067 1661-6596 https://doaj.org/article/60c1a4df92644ff5848c77905b48bf83 |
op_doi |
https://doi.org/10.3390/ijms22105259 |
container_title |
International Journal of Molecular Sciences |
container_volume |
22 |
container_issue |
10 |
container_start_page |
5259 |
_version_ |
1766393285853577216 |