Specific Profiles and Amplification of Resistance to Anti-tuberculosis Drugs in Tuberculosis Patients in the Republic of Karelia
The objective: to determine the frequency of resistance of Mycobacterium tuberculosis (MTB) to the most effective anti-tuberculosis drugs in tuberculosis patients in the Republic of Karelia, to characterize cases of amplification of MTB drug resistance during chemotherapy (CT).Subjects and Methods....
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New Terra Publishing House
2022
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Online Access: | https://doi.org/10.21292/2075-1230-2022-100-9-21-26 https://doaj.org/article/6074c8a6b046489ea1bbf49ae2c16c68 |
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ftdoajarticles:oai:doaj.org/article:6074c8a6b046489ea1bbf49ae2c16c68 2023-10-09T21:55:36+02:00 Specific Profiles and Amplification of Resistance to Anti-tuberculosis Drugs in Tuberculosis Patients in the Republic of Karelia Yu. M. Markelov E. N. Belyaeva T. V. Sunchalina 2022-10-01T00:00:00Z https://doi.org/10.21292/2075-1230-2022-100-9-21-26 https://doaj.org/article/6074c8a6b046489ea1bbf49ae2c16c68 RU rus New Terra Publishing House https://www.tibl-journal.com/jour/article/view/1673 https://doaj.org/toc/2075-1230 https://doaj.org/toc/2542-1506 2075-1230 2542-1506 doi:10.21292/2075-1230-2022-100-9-21-26 https://doaj.org/article/6074c8a6b046489ea1bbf49ae2c16c68 Туберкулез и болезни лёгких, Vol 100, Iss 9, Pp 21-26 (2022) множественная и широкая лекарственная устойчивость микобактерий туберкулеза амплификация лекарственной устойчивости Diseases of the respiratory system RC705-779 article 2022 ftdoajarticles https://doi.org/10.21292/2075-1230-2022-100-9-21-26 2023-09-10T00:41:28Z The objective: to determine the frequency of resistance of Mycobacterium tuberculosis (MTB) to the most effective anti-tuberculosis drugs in tuberculosis patients in the Republic of Karelia, to characterize cases of amplification of MTB drug resistance during chemotherapy (CT).Subjects and Methods. MTB cultures of 1,137 tuberculosis patients were studied, the patients received chemotherapy from 2016 to 2021, among them 634 (55.8%) had multiple drug resistance (MDR). Among MBT cultures with MDR, there was a high frequency of MTB with extensive drug resistance (XDR) – 42.3% (268/634) including new cases. It provided a negative impact on the chemotherapy efficacy. Most often, amplification of MTB drug resistance was observed in patients treated as per regimen IV – 37/49 (75.5%) cases. MTB drug resistance amplified more often in the cases who were already resistant to 3 and more anti-tuberculosis drugs, 31/49 (63.3%). Most often, amplification was noted in aminoglycosides (Km, Am) and glycopeptide (Cm), (71.6% of cases). The high frequency of MTB drug resistance amplification from MDR up to XDR was due to the lack of rapid molecular genetic methods to test drug susceptibility to fluoroquinolones and aminoglycosides. Article in Journal/Newspaper Republic of Karelia Directory of Open Access Journals: DOAJ Articles Tuberculosis and Lung Diseases 100 9 21 26 |
institution |
Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
Russian |
topic |
множественная и широкая лекарственная устойчивость микобактерий туберкулеза амплификация лекарственной устойчивости Diseases of the respiratory system RC705-779 |
spellingShingle |
множественная и широкая лекарственная устойчивость микобактерий туберкулеза амплификация лекарственной устойчивости Diseases of the respiratory system RC705-779 Yu. M. Markelov E. N. Belyaeva T. V. Sunchalina Specific Profiles and Amplification of Resistance to Anti-tuberculosis Drugs in Tuberculosis Patients in the Republic of Karelia |
topic_facet |
множественная и широкая лекарственная устойчивость микобактерий туберкулеза амплификация лекарственной устойчивости Diseases of the respiratory system RC705-779 |
description |
The objective: to determine the frequency of resistance of Mycobacterium tuberculosis (MTB) to the most effective anti-tuberculosis drugs in tuberculosis patients in the Republic of Karelia, to characterize cases of amplification of MTB drug resistance during chemotherapy (CT).Subjects and Methods. MTB cultures of 1,137 tuberculosis patients were studied, the patients received chemotherapy from 2016 to 2021, among them 634 (55.8%) had multiple drug resistance (MDR). Among MBT cultures with MDR, there was a high frequency of MTB with extensive drug resistance (XDR) – 42.3% (268/634) including new cases. It provided a negative impact on the chemotherapy efficacy. Most often, amplification of MTB drug resistance was observed in patients treated as per regimen IV – 37/49 (75.5%) cases. MTB drug resistance amplified more often in the cases who were already resistant to 3 and more anti-tuberculosis drugs, 31/49 (63.3%). Most often, amplification was noted in aminoglycosides (Km, Am) and glycopeptide (Cm), (71.6% of cases). The high frequency of MTB drug resistance amplification from MDR up to XDR was due to the lack of rapid molecular genetic methods to test drug susceptibility to fluoroquinolones and aminoglycosides. |
format |
Article in Journal/Newspaper |
author |
Yu. M. Markelov E. N. Belyaeva T. V. Sunchalina |
author_facet |
Yu. M. Markelov E. N. Belyaeva T. V. Sunchalina |
author_sort |
Yu. M. Markelov |
title |
Specific Profiles and Amplification of Resistance to Anti-tuberculosis Drugs in Tuberculosis Patients in the Republic of Karelia |
title_short |
Specific Profiles and Amplification of Resistance to Anti-tuberculosis Drugs in Tuberculosis Patients in the Republic of Karelia |
title_full |
Specific Profiles and Amplification of Resistance to Anti-tuberculosis Drugs in Tuberculosis Patients in the Republic of Karelia |
title_fullStr |
Specific Profiles and Amplification of Resistance to Anti-tuberculosis Drugs in Tuberculosis Patients in the Republic of Karelia |
title_full_unstemmed |
Specific Profiles and Amplification of Resistance to Anti-tuberculosis Drugs in Tuberculosis Patients in the Republic of Karelia |
title_sort |
specific profiles and amplification of resistance to anti-tuberculosis drugs in tuberculosis patients in the republic of karelia |
publisher |
New Terra Publishing House |
publishDate |
2022 |
url |
https://doi.org/10.21292/2075-1230-2022-100-9-21-26 https://doaj.org/article/6074c8a6b046489ea1bbf49ae2c16c68 |
genre |
Republic of Karelia |
genre_facet |
Republic of Karelia |
op_source |
Туберкулез и болезни лёгких, Vol 100, Iss 9, Pp 21-26 (2022) |
op_relation |
https://www.tibl-journal.com/jour/article/view/1673 https://doaj.org/toc/2075-1230 https://doaj.org/toc/2542-1506 2075-1230 2542-1506 doi:10.21292/2075-1230-2022-100-9-21-26 https://doaj.org/article/6074c8a6b046489ea1bbf49ae2c16c68 |
op_doi |
https://doi.org/10.21292/2075-1230-2022-100-9-21-26 |
container_title |
Tuberculosis and Lung Diseases |
container_volume |
100 |
container_issue |
9 |
container_start_page |
21 |
op_container_end_page |
26 |
_version_ |
1779319569308975104 |