MicroRNA-30e* suppresses dengue virus replication by promoting NF-κB-dependent IFN production.
MicroRNAs have been shown to contribute to a repertoire of host-pathogen interactions during viral infection. Our previous study demonstrated that microRNA-30e* (miR-30e*) directly targeted the IκBα 3'-UTR and disrupted the NF-κB/IκBα negative feedback loop, leading to hyperactivation of NF-κB....
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ftdoajarticles:oai:doaj.org/article:5ffd630f737242c3990cdac984c693d5 2023-05-15T15:05:44+02:00 MicroRNA-30e* suppresses dengue virus replication by promoting NF-κB-dependent IFN production. Xun Zhu Zhenjian He Yiwen Hu Weitao Wen Cuiji Lin Jianchen Yu Jing Pan Ran Li Haijing Deng Shaowei Liao Jie Yuan Jueheng Wu Jun Li Mengfeng Li 2014-08-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0003088 https://doaj.org/article/5ffd630f737242c3990cdac984c693d5 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC4133224?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0003088 https://doaj.org/article/5ffd630f737242c3990cdac984c693d5 PLoS Neglected Tropical Diseases, Vol 8, Iss 8, p e3088 (2014) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2014 ftdoajarticles https://doi.org/10.1371/journal.pntd.0003088 2022-12-31T02:26:55Z MicroRNAs have been shown to contribute to a repertoire of host-pathogen interactions during viral infection. Our previous study demonstrated that microRNA-30e* (miR-30e*) directly targeted the IκBα 3'-UTR and disrupted the NF-κB/IκBα negative feedback loop, leading to hyperactivation of NF-κB. This current study investigated the possible role of miR-30e* in the regulation of innate immunity associated with dengue virus (DENV) infection. We found that DENV infection could induce miR-30e* expression in DENV-permissive cells, and such an overexpression of miR-30e* upregulated IFN-β and the downstream IFN-stimulated genes (ISGs) such as OAS1, MxA and IFITM1, and suppressed DENV replication. Furthermore, suppression of IκBα mediates the enhancing effect of miR-30e* on IFN-β-induced antiviral response. Collectively, our findings suggest a modulatory role of miR-30e* in DENV induced IFN-β signaling via the NF-κB-dependent pathway. Further investigation is needed to evaluate whether miR-30e* has an anti-DENV effect in vivo. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 8 8 e3088 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Xun Zhu Zhenjian He Yiwen Hu Weitao Wen Cuiji Lin Jianchen Yu Jing Pan Ran Li Haijing Deng Shaowei Liao Jie Yuan Jueheng Wu Jun Li Mengfeng Li MicroRNA-30e* suppresses dengue virus replication by promoting NF-κB-dependent IFN production. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
MicroRNAs have been shown to contribute to a repertoire of host-pathogen interactions during viral infection. Our previous study demonstrated that microRNA-30e* (miR-30e*) directly targeted the IκBα 3'-UTR and disrupted the NF-κB/IκBα negative feedback loop, leading to hyperactivation of NF-κB. This current study investigated the possible role of miR-30e* in the regulation of innate immunity associated with dengue virus (DENV) infection. We found that DENV infection could induce miR-30e* expression in DENV-permissive cells, and such an overexpression of miR-30e* upregulated IFN-β and the downstream IFN-stimulated genes (ISGs) such as OAS1, MxA and IFITM1, and suppressed DENV replication. Furthermore, suppression of IκBα mediates the enhancing effect of miR-30e* on IFN-β-induced antiviral response. Collectively, our findings suggest a modulatory role of miR-30e* in DENV induced IFN-β signaling via the NF-κB-dependent pathway. Further investigation is needed to evaluate whether miR-30e* has an anti-DENV effect in vivo. |
format |
Article in Journal/Newspaper |
author |
Xun Zhu Zhenjian He Yiwen Hu Weitao Wen Cuiji Lin Jianchen Yu Jing Pan Ran Li Haijing Deng Shaowei Liao Jie Yuan Jueheng Wu Jun Li Mengfeng Li |
author_facet |
Xun Zhu Zhenjian He Yiwen Hu Weitao Wen Cuiji Lin Jianchen Yu Jing Pan Ran Li Haijing Deng Shaowei Liao Jie Yuan Jueheng Wu Jun Li Mengfeng Li |
author_sort |
Xun Zhu |
title |
MicroRNA-30e* suppresses dengue virus replication by promoting NF-κB-dependent IFN production. |
title_short |
MicroRNA-30e* suppresses dengue virus replication by promoting NF-κB-dependent IFN production. |
title_full |
MicroRNA-30e* suppresses dengue virus replication by promoting NF-κB-dependent IFN production. |
title_fullStr |
MicroRNA-30e* suppresses dengue virus replication by promoting NF-κB-dependent IFN production. |
title_full_unstemmed |
MicroRNA-30e* suppresses dengue virus replication by promoting NF-κB-dependent IFN production. |
title_sort |
microrna-30e* suppresses dengue virus replication by promoting nf-κb-dependent ifn production. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2014 |
url |
https://doi.org/10.1371/journal.pntd.0003088 https://doaj.org/article/5ffd630f737242c3990cdac984c693d5 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 8, Iss 8, p e3088 (2014) |
op_relation |
http://europepmc.org/articles/PMC4133224?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0003088 https://doaj.org/article/5ffd630f737242c3990cdac984c693d5 |
op_doi |
https://doi.org/10.1371/journal.pntd.0003088 |
container_title |
PLoS Neglected Tropical Diseases |
container_volume |
8 |
container_issue |
8 |
container_start_page |
e3088 |
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1766337384257945600 |