Efecto de la terapia antirretroviral sobre el perfil lipídico de pacientes con Sida en Maracaibo, estado Zulia, Venezuela

• Main Authors: Soto Isabel, Villalobos-B María, Villalobos-P Rafael
• Format: Article in Journal/Newspaper
• Language: English; Spanish
• Published: Universidad del Zulia,Facultad de Medicina,Departamento de Enfermedades Infecciosas y Tropicales 2010
• Subjects: Sida; terapia antirretroviral; perfil lipídico; AIDS; anti-retroviral therapy; lipidic profile; Arctic medicine. Tropical medicine; RC955-962; Public aspects of medicine; RA1-1270; Arctic
• Online Access: https://doaj.org/article/5ffc4cc46dbd4e05b63f86b534bd6d63

Abstract: A prospective study was carried out to determine the effect of antiretroviral therapy on the lipid profile in a population of 50 patients with AIDS who received their first antiretroviral drug treatment in the HIV-AIDS clinic at the Maracaibo University Hospital from November 2008 to July 2009. Serum levels of cholesterol, triglycerides, HDL-cholesterol and LDL-cholesterol were determined at the beginning and the end of the study. The therapeutic combinations were: 47 patients (94.0%) with the protease/booster inhibitors (IP/b) + nucleoside inhibitors of reverse transcriptase (NRTI) and 3 (6%) with 2 NRTI + 1 non-nucleoside inhibitors of reverse transcriptase inhibitors (NNRTIs). Initially, lipid profile parameters were inside the range of normality. By the end of the study, blood levels for triglycerides, total cholesterol and LDLc had increased with regard to the initial values.Conclusions are that hypertriglyceridemia is a frequent alteration in patients that receive antiretroviral therapy with PI/b combined with NRTI, since this constituted most of the sample studied. Resumen: Se realizó una investigación prospectiva con el objetivo de determinar el efecto de la terapia antirretroviral sobre el perfil lipídico en una población de 50 pacientes con sida, que recibían su primer esquema antirretroviral, que asisten a la consulta de VIH-SIDA del Hospital Universitario de Maracaibo durante los meses de Noviembre 2008 a Julio de 2009. Se determinaron los niveles séricos de colesterol, triglicéridos, HDL-colesterol, LDL-colesterol al inicio y al finalizar el estudio. Las combinaciones terapéuticas fueron; 47 (94,0%) con inhibidores de la proteasa/reforzado (IP/r) + inhibidores nucleosidos de la trancriptasa reversa (INTR) y 3 (6%) 2 INTR + 1 INNTR. En todos los pacientes los parámetros del perfil lipídico estaban dentro del rango de la normalidad. Al final del estudio, los niveles sanguíneos de triglicéridos, colesterol total y LDLc de los pacientes tratados aumentaron con respecto a los valores iniciales. ...