Efficacy of sertraline against Trypanosoma cruzi: an in vitro and in silico study

• Published in: Journal of Venomous Animals and Toxins including Tropical Diseases
• Main Authors: Daiane Dias Ferreira, Juliana Tonini Mesquita, Thais Alves da Costa Silva, Maiara Maria Romanelli, Denise da Gama Jaen Batista, Cristiane França da Silva, Aline Nefertiti Silva da Gama, Bruno Junior Neves, Cleber Camilo Melo-Filho, Maria de Nazare Correia Soeiro, Carolina Horta Andrade, Andre Gustavo Tempone
• Format: Article in Journal/Newspaper
• Language: English
• Published: SciELO 2018
• Subjects: Trypanosoma cruzi; Drug; Treatment; Sertraline; Drug repurposing; Drug repositioning; Arctic medicine. Tropical medicine; RC955-962; Toxicology. Poisons; RA1190-1270; Zoology; QL1-991; Arctic; The ''Y''
• Online Access: https://doi.org/10.1186/s40409-018-0165-8; https://doaj.org/article/5fea82da8c5541068b69e7ccd07d156e

Abstract Background Drug repurposing has been an interesting and cost-effective approach, especially for neglected diseases, such as Chagas disease. Methods In this work, we studied the activity of the antidepressant drug sertraline against Trypanosoma cruzi trypomastigotes and intracellular amastig...