Missed, Not Missing: Phylogenomic Evidence for the Existence of Avian FoxP3.
The Forkhead box transcription factor FoxP3 is pivotal to the development and function of regulatory T cells (Tregs), which make a major contribution to peripheral tolerance. FoxP3 is believed to perform a regulatory role in all the vertebrate species in which it has been detected. The prevailing vi...
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ftdoajarticles:oai:doaj.org/article:5fcc784223b44c9ba30b386e0b0cc806 2023-05-15T16:09:57+02:00 Missed, Not Missing: Phylogenomic Evidence for the Existence of Avian FoxP3. Michael P Denyer Dammy Y Pinheiro Oliver A Garden Adrian J Shepherd 2016-01-01T00:00:00Z https://doi.org/10.1371/journal.pone.0150988 https://doaj.org/article/5fcc784223b44c9ba30b386e0b0cc806 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC4777427?pdf=render https://doaj.org/toc/1932-6203 1932-6203 doi:10.1371/journal.pone.0150988 https://doaj.org/article/5fcc784223b44c9ba30b386e0b0cc806 PLoS ONE, Vol 11, Iss 3, p e0150988 (2016) Medicine R Science Q article 2016 ftdoajarticles https://doi.org/10.1371/journal.pone.0150988 2022-12-31T08:52:40Z The Forkhead box transcription factor FoxP3 is pivotal to the development and function of regulatory T cells (Tregs), which make a major contribution to peripheral tolerance. FoxP3 is believed to perform a regulatory role in all the vertebrate species in which it has been detected. The prevailing view is that FoxP3 is absent in birds and that avian Tregs rely on alternative developmental and suppressive pathways. Prompted by the automated annotation of foxp3 in the ground tit (Parus humilis) genome, we have questioned this assumption. Our analysis of all available avian genomes has revealed that the foxp3 locus is missing, incomplete or of poor quality in the relevant genomic assemblies for nearly all avian species. Nevertheless, in two species, the peregrine falcon (Falco peregrinus) and the saker falcon (F. cherrug), there is compelling evidence for the existence of exons showing synteny with foxp3 in the ground tit. A broader phylogenomic analysis has shown that FoxP3 sequences from these three species are similar to crocodilian sequences, the closest living relatives of birds. In both birds and crocodilians, we have also identified a highly proline-enriched region at the N terminus of FoxP3, a region previously identified only in mammals. Article in Journal/Newspaper Falco peregrinus peregrine falcon Directory of Open Access Journals: DOAJ Articles Parus ENVELOPE(3.950,3.950,-71.983,-71.983) PLOS ONE 11 3 e0150988 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Medicine R Science Q |
spellingShingle |
Medicine R Science Q Michael P Denyer Dammy Y Pinheiro Oliver A Garden Adrian J Shepherd Missed, Not Missing: Phylogenomic Evidence for the Existence of Avian FoxP3. |
topic_facet |
Medicine R Science Q |
description |
The Forkhead box transcription factor FoxP3 is pivotal to the development and function of regulatory T cells (Tregs), which make a major contribution to peripheral tolerance. FoxP3 is believed to perform a regulatory role in all the vertebrate species in which it has been detected. The prevailing view is that FoxP3 is absent in birds and that avian Tregs rely on alternative developmental and suppressive pathways. Prompted by the automated annotation of foxp3 in the ground tit (Parus humilis) genome, we have questioned this assumption. Our analysis of all available avian genomes has revealed that the foxp3 locus is missing, incomplete or of poor quality in the relevant genomic assemblies for nearly all avian species. Nevertheless, in two species, the peregrine falcon (Falco peregrinus) and the saker falcon (F. cherrug), there is compelling evidence for the existence of exons showing synteny with foxp3 in the ground tit. A broader phylogenomic analysis has shown that FoxP3 sequences from these three species are similar to crocodilian sequences, the closest living relatives of birds. In both birds and crocodilians, we have also identified a highly proline-enriched region at the N terminus of FoxP3, a region previously identified only in mammals. |
format |
Article in Journal/Newspaper |
author |
Michael P Denyer Dammy Y Pinheiro Oliver A Garden Adrian J Shepherd |
author_facet |
Michael P Denyer Dammy Y Pinheiro Oliver A Garden Adrian J Shepherd |
author_sort |
Michael P Denyer |
title |
Missed, Not Missing: Phylogenomic Evidence for the Existence of Avian FoxP3. |
title_short |
Missed, Not Missing: Phylogenomic Evidence for the Existence of Avian FoxP3. |
title_full |
Missed, Not Missing: Phylogenomic Evidence for the Existence of Avian FoxP3. |
title_fullStr |
Missed, Not Missing: Phylogenomic Evidence for the Existence of Avian FoxP3. |
title_full_unstemmed |
Missed, Not Missing: Phylogenomic Evidence for the Existence of Avian FoxP3. |
title_sort |
missed, not missing: phylogenomic evidence for the existence of avian foxp3. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2016 |
url |
https://doi.org/10.1371/journal.pone.0150988 https://doaj.org/article/5fcc784223b44c9ba30b386e0b0cc806 |
long_lat |
ENVELOPE(3.950,3.950,-71.983,-71.983) |
geographic |
Parus |
geographic_facet |
Parus |
genre |
Falco peregrinus peregrine falcon |
genre_facet |
Falco peregrinus peregrine falcon |
op_source |
PLoS ONE, Vol 11, Iss 3, p e0150988 (2016) |
op_relation |
http://europepmc.org/articles/PMC4777427?pdf=render https://doaj.org/toc/1932-6203 1932-6203 doi:10.1371/journal.pone.0150988 https://doaj.org/article/5fcc784223b44c9ba30b386e0b0cc806 |
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https://doi.org/10.1371/journal.pone.0150988 |
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PLOS ONE |
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11 |
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3 |
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e0150988 |
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