Human plague associated with Tibetan sheep originates in marmots.
The Qinghai-Tibet plateau is a natural plague focus and is the largest such focus in China. In this area, while Marmota himalayana is the primary host, a total of 18 human plague outbreaks associated with Tibetan sheep (78 cases with 47 deaths) have been reported on the Qinghai-Tibet plateau since 1...
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ftdoajarticles:oai:doaj.org/article:5f42c76fa0c341409cd38b976944516b 2023-05-15T15:07:28+02:00 Human plague associated with Tibetan sheep originates in marmots. Ruixia Dai Baiqing Wei Haoming Xiong Xiaoyan Yang Yao Peng Jian He Juan Jin Yumeng Wang Xi Zha Zhikai Zhang Ying Liang Qingwen Zhang Jianguo Xu Zuyun Wang Wei Li 2018-08-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0006635 https://doaj.org/article/5f42c76fa0c341409cd38b976944516b EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC6095483?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0006635 https://doaj.org/article/5f42c76fa0c341409cd38b976944516b PLoS Neglected Tropical Diseases, Vol 12, Iss 8, p e0006635 (2018) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2018 ftdoajarticles https://doi.org/10.1371/journal.pntd.0006635 2022-12-31T14:37:37Z The Qinghai-Tibet plateau is a natural plague focus and is the largest such focus in China. In this area, while Marmota himalayana is the primary host, a total of 18 human plague outbreaks associated with Tibetan sheep (78 cases with 47 deaths) have been reported on the Qinghai-Tibet plateau since 1956. All of the index infectious cases had an exposure history of slaughtering or skinning diseased or dead Tibetan sheep. In this study, we sequenced and compared 38 strains of Yersinia pestis isolated from different hosts, including humans, Tibetan sheep, and M. himalayana. Phylogenetic relationships were reconstructed based on genome-wide single-nucleotide polymorphisms identified from our isolates and reference strains. The phylogenetic relationships illustrated in our study, together with the finding that the Tibetan sheep plague clearly lagged behind the M. himalayana plague, and a previous study that identified the Tibetan sheep as a plague reservoir with high susceptibility and moderate sensitivity, indicated that the human plague was transmitted from Tibetan sheep, while the Tibetan sheep plague originated from marmots. Tibetan sheep may encounter this infection by contact with dead rodents or through being bitten by fleas originating from M. himalayana during local epizootics. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 12 8 e0006635 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Ruixia Dai Baiqing Wei Haoming Xiong Xiaoyan Yang Yao Peng Jian He Juan Jin Yumeng Wang Xi Zha Zhikai Zhang Ying Liang Qingwen Zhang Jianguo Xu Zuyun Wang Wei Li Human plague associated with Tibetan sheep originates in marmots. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
The Qinghai-Tibet plateau is a natural plague focus and is the largest such focus in China. In this area, while Marmota himalayana is the primary host, a total of 18 human plague outbreaks associated with Tibetan sheep (78 cases with 47 deaths) have been reported on the Qinghai-Tibet plateau since 1956. All of the index infectious cases had an exposure history of slaughtering or skinning diseased or dead Tibetan sheep. In this study, we sequenced and compared 38 strains of Yersinia pestis isolated from different hosts, including humans, Tibetan sheep, and M. himalayana. Phylogenetic relationships were reconstructed based on genome-wide single-nucleotide polymorphisms identified from our isolates and reference strains. The phylogenetic relationships illustrated in our study, together with the finding that the Tibetan sheep plague clearly lagged behind the M. himalayana plague, and a previous study that identified the Tibetan sheep as a plague reservoir with high susceptibility and moderate sensitivity, indicated that the human plague was transmitted from Tibetan sheep, while the Tibetan sheep plague originated from marmots. Tibetan sheep may encounter this infection by contact with dead rodents or through being bitten by fleas originating from M. himalayana during local epizootics. |
format |
Article in Journal/Newspaper |
author |
Ruixia Dai Baiqing Wei Haoming Xiong Xiaoyan Yang Yao Peng Jian He Juan Jin Yumeng Wang Xi Zha Zhikai Zhang Ying Liang Qingwen Zhang Jianguo Xu Zuyun Wang Wei Li |
author_facet |
Ruixia Dai Baiqing Wei Haoming Xiong Xiaoyan Yang Yao Peng Jian He Juan Jin Yumeng Wang Xi Zha Zhikai Zhang Ying Liang Qingwen Zhang Jianguo Xu Zuyun Wang Wei Li |
author_sort |
Ruixia Dai |
title |
Human plague associated with Tibetan sheep originates in marmots. |
title_short |
Human plague associated with Tibetan sheep originates in marmots. |
title_full |
Human plague associated with Tibetan sheep originates in marmots. |
title_fullStr |
Human plague associated with Tibetan sheep originates in marmots. |
title_full_unstemmed |
Human plague associated with Tibetan sheep originates in marmots. |
title_sort |
human plague associated with tibetan sheep originates in marmots. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2018 |
url |
https://doi.org/10.1371/journal.pntd.0006635 https://doaj.org/article/5f42c76fa0c341409cd38b976944516b |
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Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 12, Iss 8, p e0006635 (2018) |
op_relation |
http://europepmc.org/articles/PMC6095483?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0006635 https://doaj.org/article/5f42c76fa0c341409cd38b976944516b |
op_doi |
https://doi.org/10.1371/journal.pntd.0006635 |
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PLOS Neglected Tropical Diseases |
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12 |
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8 |
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e0006635 |
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