Selective activity of diselenides against Aedes aegypti (Diptera: Culicidae) larvae

• Published in: Revista da Sociedade Brasileira de Medicina Tropical
• Main Authors: Sabrina Ketrin Targanski, Janaina Rosa Sousa, André Luiz Agnes Stein, Marcos Antônio Soares
• Format: Article in Journal/Newspaper
• Language: English
• Published: Sociedade Brasileira de Medicina Tropical (SBMT) 2020
• Subjects: Selenium; 1,2-diphenyldiselenide; 1,2-bis(4-chlorophenyl) diselenide; Caenorhabditis elegans; Chlorella vulgaris; Galleria mellonela; Arctic medicine. Tropical medicine; RC955-962; Arctic
• Online Access: https://doi.org/10.1590/0037-8682-0146-2020; https://doaj.org/article/5f4258663e0a44dd9326a953008b8238

Abstract INTRODUCTION: Aedes aegypti (L.) is the major vector of arboviruses that causes serious public health concerns in tropical and subtropical countries. METHODS: We examined the larvicidal activity of 1,2-diphenyldiselenide [(PhSe)2] and 1,2-bis(4-chlorophenyl) diselenide [(p-ClPhSe)2] and determine its toxicity to different non-target organisms. RESULTS: (PhSe)2 and (p-ClPhSe)2 killed Ae. aegypti L3 larvae with LC50/24h values of 65.63 µM (20.48 mg/L) and 355.19 µM (135.33 mg/L), respectively. (PhSe)2 was not toxic to the four model organisms. CONCLUSIONS: (PhSe)2 is a larvicidal compound with selective action against Ae. aegypti larvae. The mechanisms of action of (PhSe)2 under field conditions remain to be investigated.