Migrant tuberculosis: the extent of transmission in a low burden country
Abstract Background Human migration caused by political unrest, wars and poverty is a major topic in international health. Infectious diseases like tuberculosis follow their host, with potential impact on both the migrants and the population in the recipient countries. In this study, we evaluate Myc...
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ftdoajarticles:oai:doaj.org/article:5f1383a4318f474aa02e7e1ab2c294f1 2023-05-15T16:30:58+02:00 Migrant tuberculosis: the extent of transmission in a low burden country Kamper-Jørgensen Zaza Andersen Aase Kok-Jensen Axel Kamper-Jørgensen Mads Bygbjerg Ib Andersen Peter Thomsen Vibeke Lillebaek Troels 2012-03-01T00:00:00Z https://doi.org/10.1186/1471-2334-12-60 https://doaj.org/article/5f1383a4318f474aa02e7e1ab2c294f1 EN eng BMC http://www.biomedcentral.com/1471-2334/12/60 https://doaj.org/toc/1471-2334 doi:10.1186/1471-2334-12-60 1471-2334 https://doaj.org/article/5f1383a4318f474aa02e7e1ab2c294f1 BMC Infectious Diseases, Vol 12, Iss 1, p 60 (2012) Denmark Genotyping IS 6110 -RFLP Molecular epidemiology Infectious and parasitic diseases RC109-216 article 2012 ftdoajarticles https://doi.org/10.1186/1471-2334-12-60 2022-12-30T22:12:51Z Abstract Background Human migration caused by political unrest, wars and poverty is a major topic in international health. Infectious diseases like tuberculosis follow their host, with potential impact on both the migrants and the population in the recipient countries. In this study, we evaluate Mycobacterium tuberculosis transmission between the national population and migrants in Denmark. Methods Register study based on IS 6110 -RFLP results from nationwide genotyping of tuberculosis cases during 1992 through 2004. Cases with 100% identical genotypes were defined as clustered and part of a transmission chain. Origin of clusters involving both Danes and migrants was defined as Danish/migrant/uncertain. Subsequently, the proportion of cases likely infected by the "opposite" ethnic group was estimated. Results 4,631 cases were included, representing 99% of culture confirmed cases during 1992 through 2004. Migrants contributed 61.6% of cases. Up to 7.9% (95% CI 7.0-8.9) of migrants were infected by Danes. The corresponding figure was 5.8% (95% CI 4.8-7.0) for Danes. Thus, transmission from Danes to migrants occurred up to 2.5 (95% CI 1.8-3.5) times more frequent than vice versa (OR = 1). A dominant strain, Cluster-2, was almost exclusively found in Danes, particular younger-middle-aged males. Conclusions Transmission between Danes and migrants is limited, and risk of being infected by the "opposite" ethnic group is highest for migrants. TB-control efforts should focus on continues micro-epidemics, e.g. with Cluster-2 in Danes, prevention of reactivation TB in high-risk migrants, and outbreaks in socially marginalized migrants, such as Somalis and Greenlanders. Fears that TB in migrants poses a threat for resident Danes seem exaggerated and unjustified. We believe this to be true for other low incidence countries as well. Article in Journal/Newspaper greenlander* Directory of Open Access Journals: DOAJ Articles BMC Infectious Diseases 12 1 |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Denmark Genotyping IS 6110 -RFLP Molecular epidemiology Infectious and parasitic diseases RC109-216 |
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Denmark Genotyping IS 6110 -RFLP Molecular epidemiology Infectious and parasitic diseases RC109-216 Kamper-Jørgensen Zaza Andersen Aase Kok-Jensen Axel Kamper-Jørgensen Mads Bygbjerg Ib Andersen Peter Thomsen Vibeke Lillebaek Troels Migrant tuberculosis: the extent of transmission in a low burden country |
topic_facet |
Denmark Genotyping IS 6110 -RFLP Molecular epidemiology Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Human migration caused by political unrest, wars and poverty is a major topic in international health. Infectious diseases like tuberculosis follow their host, with potential impact on both the migrants and the population in the recipient countries. In this study, we evaluate Mycobacterium tuberculosis transmission between the national population and migrants in Denmark. Methods Register study based on IS 6110 -RFLP results from nationwide genotyping of tuberculosis cases during 1992 through 2004. Cases with 100% identical genotypes were defined as clustered and part of a transmission chain. Origin of clusters involving both Danes and migrants was defined as Danish/migrant/uncertain. Subsequently, the proportion of cases likely infected by the "opposite" ethnic group was estimated. Results 4,631 cases were included, representing 99% of culture confirmed cases during 1992 through 2004. Migrants contributed 61.6% of cases. Up to 7.9% (95% CI 7.0-8.9) of migrants were infected by Danes. The corresponding figure was 5.8% (95% CI 4.8-7.0) for Danes. Thus, transmission from Danes to migrants occurred up to 2.5 (95% CI 1.8-3.5) times more frequent than vice versa (OR = 1). A dominant strain, Cluster-2, was almost exclusively found in Danes, particular younger-middle-aged males. Conclusions Transmission between Danes and migrants is limited, and risk of being infected by the "opposite" ethnic group is highest for migrants. TB-control efforts should focus on continues micro-epidemics, e.g. with Cluster-2 in Danes, prevention of reactivation TB in high-risk migrants, and outbreaks in socially marginalized migrants, such as Somalis and Greenlanders. Fears that TB in migrants poses a threat for resident Danes seem exaggerated and unjustified. We believe this to be true for other low incidence countries as well. |
format |
Article in Journal/Newspaper |
author |
Kamper-Jørgensen Zaza Andersen Aase Kok-Jensen Axel Kamper-Jørgensen Mads Bygbjerg Ib Andersen Peter Thomsen Vibeke Lillebaek Troels |
author_facet |
Kamper-Jørgensen Zaza Andersen Aase Kok-Jensen Axel Kamper-Jørgensen Mads Bygbjerg Ib Andersen Peter Thomsen Vibeke Lillebaek Troels |
author_sort |
Kamper-Jørgensen Zaza |
title |
Migrant tuberculosis: the extent of transmission in a low burden country |
title_short |
Migrant tuberculosis: the extent of transmission in a low burden country |
title_full |
Migrant tuberculosis: the extent of transmission in a low burden country |
title_fullStr |
Migrant tuberculosis: the extent of transmission in a low burden country |
title_full_unstemmed |
Migrant tuberculosis: the extent of transmission in a low burden country |
title_sort |
migrant tuberculosis: the extent of transmission in a low burden country |
publisher |
BMC |
publishDate |
2012 |
url |
https://doi.org/10.1186/1471-2334-12-60 https://doaj.org/article/5f1383a4318f474aa02e7e1ab2c294f1 |
genre |
greenlander* |
genre_facet |
greenlander* |
op_source |
BMC Infectious Diseases, Vol 12, Iss 1, p 60 (2012) |
op_relation |
http://www.biomedcentral.com/1471-2334/12/60 https://doaj.org/toc/1471-2334 doi:10.1186/1471-2334-12-60 1471-2334 https://doaj.org/article/5f1383a4318f474aa02e7e1ab2c294f1 |
op_doi |
https://doi.org/10.1186/1471-2334-12-60 |
container_title |
BMC Infectious Diseases |
container_volume |
12 |
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1 |
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1766020775506083840 |