Drug resistance and treatment failure in leishmaniasis: A 21st century challenge.
Reevaluation of treatment guidelines for Old and New World leishmaniasis is urgently needed on a global basis because treatment failure is an increasing problem. Drug resistance is a fundamental determinant of treatment failure, although other factors also contribute to this phenomenon, including th...
Published in: | PLOS Neglected Tropical Diseases |
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Online Access: | https://doi.org/10.1371/journal.pntd.0006052 https://doaj.org/article/5f0c7b9c1030434c8c5c6249ae3f5cbe |
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ftdoajarticles:oai:doaj.org/article:5f0c7b9c1030434c8c5c6249ae3f5cbe 2023-05-15T15:04:43+02:00 Drug resistance and treatment failure in leishmaniasis: A 21st century challenge. Alicia Ponte-Sucre Francisco Gamarro Jean-Claude Dujardin Michael P Barrett Rogelio López-Vélez Raquel García-Hernández Andrew W Pountain Roy Mwenechanya Barbara Papadopoulou 2017-12-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0006052 https://doaj.org/article/5f0c7b9c1030434c8c5c6249ae3f5cbe EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC5730103?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0006052 https://doaj.org/article/5f0c7b9c1030434c8c5c6249ae3f5cbe PLoS Neglected Tropical Diseases, Vol 11, Iss 12, p e0006052 (2017) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2017 ftdoajarticles https://doi.org/10.1371/journal.pntd.0006052 2022-12-30T20:53:18Z Reevaluation of treatment guidelines for Old and New World leishmaniasis is urgently needed on a global basis because treatment failure is an increasing problem. Drug resistance is a fundamental determinant of treatment failure, although other factors also contribute to this phenomenon, including the global HIV/AIDS epidemic with its accompanying impact on the immune system. Pentavalent antimonials have been used successfully worldwide for the treatment of leishmaniasis since the first half of the 20th century, but the last 10 to 20 years have witnessed an increase in clinical resistance, e.g., in North Bihar in India. In this review, we discuss the meaning of "resistance" related to leishmaniasis and discuss its molecular epidemiology, particularly for Leishmania donovani that causes visceral leishmaniasis. We also discuss how resistance can affect drug combination therapies. Molecular mechanisms known to contribute to resistance to antimonials, amphotericin B, and miltefosine are also outlined. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 11 12 e0006052 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Alicia Ponte-Sucre Francisco Gamarro Jean-Claude Dujardin Michael P Barrett Rogelio López-Vélez Raquel García-Hernández Andrew W Pountain Roy Mwenechanya Barbara Papadopoulou Drug resistance and treatment failure in leishmaniasis: A 21st century challenge. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Reevaluation of treatment guidelines for Old and New World leishmaniasis is urgently needed on a global basis because treatment failure is an increasing problem. Drug resistance is a fundamental determinant of treatment failure, although other factors also contribute to this phenomenon, including the global HIV/AIDS epidemic with its accompanying impact on the immune system. Pentavalent antimonials have been used successfully worldwide for the treatment of leishmaniasis since the first half of the 20th century, but the last 10 to 20 years have witnessed an increase in clinical resistance, e.g., in North Bihar in India. In this review, we discuss the meaning of "resistance" related to leishmaniasis and discuss its molecular epidemiology, particularly for Leishmania donovani that causes visceral leishmaniasis. We also discuss how resistance can affect drug combination therapies. Molecular mechanisms known to contribute to resistance to antimonials, amphotericin B, and miltefosine are also outlined. |
format |
Article in Journal/Newspaper |
author |
Alicia Ponte-Sucre Francisco Gamarro Jean-Claude Dujardin Michael P Barrett Rogelio López-Vélez Raquel García-Hernández Andrew W Pountain Roy Mwenechanya Barbara Papadopoulou |
author_facet |
Alicia Ponte-Sucre Francisco Gamarro Jean-Claude Dujardin Michael P Barrett Rogelio López-Vélez Raquel García-Hernández Andrew W Pountain Roy Mwenechanya Barbara Papadopoulou |
author_sort |
Alicia Ponte-Sucre |
title |
Drug resistance and treatment failure in leishmaniasis: A 21st century challenge. |
title_short |
Drug resistance and treatment failure in leishmaniasis: A 21st century challenge. |
title_full |
Drug resistance and treatment failure in leishmaniasis: A 21st century challenge. |
title_fullStr |
Drug resistance and treatment failure in leishmaniasis: A 21st century challenge. |
title_full_unstemmed |
Drug resistance and treatment failure in leishmaniasis: A 21st century challenge. |
title_sort |
drug resistance and treatment failure in leishmaniasis: a 21st century challenge. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2017 |
url |
https://doi.org/10.1371/journal.pntd.0006052 https://doaj.org/article/5f0c7b9c1030434c8c5c6249ae3f5cbe |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 11, Iss 12, p e0006052 (2017) |
op_relation |
http://europepmc.org/articles/PMC5730103?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0006052 https://doaj.org/article/5f0c7b9c1030434c8c5c6249ae3f5cbe |
op_doi |
https://doi.org/10.1371/journal.pntd.0006052 |
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PLOS Neglected Tropical Diseases |
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11 |
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12 |
container_start_page |
e0006052 |
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1766336447246237696 |