The spectrum of neurological disease associated with Zika and chikungunya viruses in adults in Rio de Janeiro, Brazil: A case series.
Background During 2015-16 Brazil experienced the largest epidemic of Zika virus ever reported. This arthropod-borne virus (arbovirus) has been linked to Guillain-Barré syndrome (GBS) in adults but other neurological associations are uncertain. Chikungunya virus has caused outbreaks in Brazil since 2...
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ftdoajarticles:oai:doaj.org/article:5ef1adb97177473f99e214a676114b3f 2023-05-15T15:13:41+02:00 The spectrum of neurological disease associated with Zika and chikungunya viruses in adults in Rio de Janeiro, Brazil: A case series. Ravi Mehta Cristiane Nascimento Soares Raquel Medialdea-Carrera Mark Ellul Marcus Tulius Texeira da Silva Anna Rosala-Hallas Marcia Rodrigues Jardim Girvan Burnside Luciana Pamplona Maneesh Bhojak Radhika Manohar Gabriel Amorelli Medeiros da Silva Marcus Vinicius Adriano Patricia Brasil Rita Maria Ribeiro Nogueira Carolina Cardoso Dos Santos Lance Turtle Patricia Carvalho de Sequeira David W Brown Michael J Griffiths Ana Maria Bispo de Filippis Tom Solomon 2018-02-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0006212 https://doaj.org/article/5ef1adb97177473f99e214a676114b3f EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0006212 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0006212 https://doaj.org/article/5ef1adb97177473f99e214a676114b3f PLoS Neglected Tropical Diseases, Vol 12, Iss 2, p e0006212 (2018) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2018 ftdoajarticles https://doi.org/10.1371/journal.pntd.0006212 2022-12-31T15:12:18Z Background During 2015-16 Brazil experienced the largest epidemic of Zika virus ever reported. This arthropod-borne virus (arbovirus) has been linked to Guillain-Barré syndrome (GBS) in adults but other neurological associations are uncertain. Chikungunya virus has caused outbreaks in Brazil since 2014 but associated neurological disease has rarely been reported here. We investigated adults with acute neurological disorders for Zika, chikungunya and dengue, another arbovirus circulating in Brazil. Methods We studied adults who had developed a new neurological condition following suspected Zika virus infection between 1st November 2015 and 1st June 2016. Cerebrospinal fluid (CSF), serum, and urine were tested for evidence of Zika, chikungunya, and dengue viruses. Results Of 35 patients studied, 22 had evidence of recent arboviral infection. Twelve had positive PCR or IgM for Zika, five of whom also had evidence for chikungunya, three for dengue, and one for all three viruses. Five of them presented with GBS; seven had presentations other than GBS, including meningoencephalitis, myelitis, radiculitis or combinations of these syndromes. Additionally, ten patients positive for chikungunya virus, two of whom also had evidence for dengue virus, presented with a similar range of neurological conditions. Conclusions Zika virus is associated with a wide range of neurological manifestations, including central nervous system disease. Chikungunya virus appears to have an equally important association with neurological disease in Brazil, and many patients had dual infection. To understand fully the burden of Zika we must look beyond GBS, and also investigate for other co-circulating arboviruses, particularly chikungunya. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Barré ENVELOPE(-68.550,-68.550,-67.500,-67.500) PLOS Neglected Tropical Diseases 12 2 e0006212 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Ravi Mehta Cristiane Nascimento Soares Raquel Medialdea-Carrera Mark Ellul Marcus Tulius Texeira da Silva Anna Rosala-Hallas Marcia Rodrigues Jardim Girvan Burnside Luciana Pamplona Maneesh Bhojak Radhika Manohar Gabriel Amorelli Medeiros da Silva Marcus Vinicius Adriano Patricia Brasil Rita Maria Ribeiro Nogueira Carolina Cardoso Dos Santos Lance Turtle Patricia Carvalho de Sequeira David W Brown Michael J Griffiths Ana Maria Bispo de Filippis Tom Solomon The spectrum of neurological disease associated with Zika and chikungunya viruses in adults in Rio de Janeiro, Brazil: A case series. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Background During 2015-16 Brazil experienced the largest epidemic of Zika virus ever reported. This arthropod-borne virus (arbovirus) has been linked to Guillain-Barré syndrome (GBS) in adults but other neurological associations are uncertain. Chikungunya virus has caused outbreaks in Brazil since 2014 but associated neurological disease has rarely been reported here. We investigated adults with acute neurological disorders for Zika, chikungunya and dengue, another arbovirus circulating in Brazil. Methods We studied adults who had developed a new neurological condition following suspected Zika virus infection between 1st November 2015 and 1st June 2016. Cerebrospinal fluid (CSF), serum, and urine were tested for evidence of Zika, chikungunya, and dengue viruses. Results Of 35 patients studied, 22 had evidence of recent arboviral infection. Twelve had positive PCR or IgM for Zika, five of whom also had evidence for chikungunya, three for dengue, and one for all three viruses. Five of them presented with GBS; seven had presentations other than GBS, including meningoencephalitis, myelitis, radiculitis or combinations of these syndromes. Additionally, ten patients positive for chikungunya virus, two of whom also had evidence for dengue virus, presented with a similar range of neurological conditions. Conclusions Zika virus is associated with a wide range of neurological manifestations, including central nervous system disease. Chikungunya virus appears to have an equally important association with neurological disease in Brazil, and many patients had dual infection. To understand fully the burden of Zika we must look beyond GBS, and also investigate for other co-circulating arboviruses, particularly chikungunya. |
format |
Article in Journal/Newspaper |
author |
Ravi Mehta Cristiane Nascimento Soares Raquel Medialdea-Carrera Mark Ellul Marcus Tulius Texeira da Silva Anna Rosala-Hallas Marcia Rodrigues Jardim Girvan Burnside Luciana Pamplona Maneesh Bhojak Radhika Manohar Gabriel Amorelli Medeiros da Silva Marcus Vinicius Adriano Patricia Brasil Rita Maria Ribeiro Nogueira Carolina Cardoso Dos Santos Lance Turtle Patricia Carvalho de Sequeira David W Brown Michael J Griffiths Ana Maria Bispo de Filippis Tom Solomon |
author_facet |
Ravi Mehta Cristiane Nascimento Soares Raquel Medialdea-Carrera Mark Ellul Marcus Tulius Texeira da Silva Anna Rosala-Hallas Marcia Rodrigues Jardim Girvan Burnside Luciana Pamplona Maneesh Bhojak Radhika Manohar Gabriel Amorelli Medeiros da Silva Marcus Vinicius Adriano Patricia Brasil Rita Maria Ribeiro Nogueira Carolina Cardoso Dos Santos Lance Turtle Patricia Carvalho de Sequeira David W Brown Michael J Griffiths Ana Maria Bispo de Filippis Tom Solomon |
author_sort |
Ravi Mehta |
title |
The spectrum of neurological disease associated with Zika and chikungunya viruses in adults in Rio de Janeiro, Brazil: A case series. |
title_short |
The spectrum of neurological disease associated with Zika and chikungunya viruses in adults in Rio de Janeiro, Brazil: A case series. |
title_full |
The spectrum of neurological disease associated with Zika and chikungunya viruses in adults in Rio de Janeiro, Brazil: A case series. |
title_fullStr |
The spectrum of neurological disease associated with Zika and chikungunya viruses in adults in Rio de Janeiro, Brazil: A case series. |
title_full_unstemmed |
The spectrum of neurological disease associated with Zika and chikungunya viruses in adults in Rio de Janeiro, Brazil: A case series. |
title_sort |
spectrum of neurological disease associated with zika and chikungunya viruses in adults in rio de janeiro, brazil: a case series. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2018 |
url |
https://doi.org/10.1371/journal.pntd.0006212 https://doaj.org/article/5ef1adb97177473f99e214a676114b3f |
long_lat |
ENVELOPE(-68.550,-68.550,-67.500,-67.500) |
geographic |
Arctic Barré |
geographic_facet |
Arctic Barré |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 12, Iss 2, p e0006212 (2018) |
op_relation |
https://doi.org/10.1371/journal.pntd.0006212 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0006212 https://doaj.org/article/5ef1adb97177473f99e214a676114b3f |
op_doi |
https://doi.org/10.1371/journal.pntd.0006212 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
12 |
container_issue |
2 |
container_start_page |
e0006212 |
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1766344212488388608 |