Late-onset ulnar neuritis following treatment of lepromatous leprosy infection.
Neuritis is a frequent complication of Myocobacteria leprae infection and treatment due to the variety of mechanisms through which it can occur. Not only can mycobacterial invasion into peripheral nerves directly cause damage and inflammation, but immune-mediated inflammatory episodes (termed lepros...
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ftdoajarticles:oai:doaj.org/article:5e9431837cf24b61a74d2cc846df8fe7 2023-05-15T15:04:05+02:00 Late-onset ulnar neuritis following treatment of lepromatous leprosy infection. Trevor Wellington Christina Schofield 2019-08-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0007684 https://doaj.org/article/5e9431837cf24b61a74d2cc846df8fe7 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0007684 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0007684 https://doaj.org/article/5e9431837cf24b61a74d2cc846df8fe7 PLoS Neglected Tropical Diseases, Vol 13, Iss 8, p e0007684 (2019) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2019 ftdoajarticles https://doi.org/10.1371/journal.pntd.0007684 2022-12-31T11:56:29Z Neuritis is a frequent complication of Myocobacteria leprae infection and treatment due to the variety of mechanisms through which it can occur. Not only can mycobacterial invasion into peripheral nerves directly cause damage and inflammation, but immune-mediated inflammatory episodes (termed leprosy reactions) can also manifest as neuritis at any point during infection. Treatment of leprosy reactions with thalidomide can also lead to neuritis due to an adverse drug effect. Neuritis can emerge years after initial diagnosis and treatment, although it is most frequently found at time of diagnosis or early into the treatment course. Treatment of neuritis is dependent on high-dose corticosteroid therapy as well as therapy for suspected underlying etiology. Here, we present a case of ulnar neuritis presenting in a patient with lepromatous leprosy four years after treatment of initial infection, with subsequent improvement after corticosteroid burst while maintained on thalidomide therapy. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 13 8 e0007684 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Trevor Wellington Christina Schofield Late-onset ulnar neuritis following treatment of lepromatous leprosy infection. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Neuritis is a frequent complication of Myocobacteria leprae infection and treatment due to the variety of mechanisms through which it can occur. Not only can mycobacterial invasion into peripheral nerves directly cause damage and inflammation, but immune-mediated inflammatory episodes (termed leprosy reactions) can also manifest as neuritis at any point during infection. Treatment of leprosy reactions with thalidomide can also lead to neuritis due to an adverse drug effect. Neuritis can emerge years after initial diagnosis and treatment, although it is most frequently found at time of diagnosis or early into the treatment course. Treatment of neuritis is dependent on high-dose corticosteroid therapy as well as therapy for suspected underlying etiology. Here, we present a case of ulnar neuritis presenting in a patient with lepromatous leprosy four years after treatment of initial infection, with subsequent improvement after corticosteroid burst while maintained on thalidomide therapy. |
format |
Article in Journal/Newspaper |
author |
Trevor Wellington Christina Schofield |
author_facet |
Trevor Wellington Christina Schofield |
author_sort |
Trevor Wellington |
title |
Late-onset ulnar neuritis following treatment of lepromatous leprosy infection. |
title_short |
Late-onset ulnar neuritis following treatment of lepromatous leprosy infection. |
title_full |
Late-onset ulnar neuritis following treatment of lepromatous leprosy infection. |
title_fullStr |
Late-onset ulnar neuritis following treatment of lepromatous leprosy infection. |
title_full_unstemmed |
Late-onset ulnar neuritis following treatment of lepromatous leprosy infection. |
title_sort |
late-onset ulnar neuritis following treatment of lepromatous leprosy infection. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2019 |
url |
https://doi.org/10.1371/journal.pntd.0007684 https://doaj.org/article/5e9431837cf24b61a74d2cc846df8fe7 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 13, Iss 8, p e0007684 (2019) |
op_relation |
https://doi.org/10.1371/journal.pntd.0007684 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0007684 https://doaj.org/article/5e9431837cf24b61a74d2cc846df8fe7 |
op_doi |
https://doi.org/10.1371/journal.pntd.0007684 |
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PLOS Neglected Tropical Diseases |
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13 |
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8 |
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e0007684 |
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