Vector competence of Aedes aegypti for different strains of Zika virus in Argentina.
The importance of Zika virus (ZIKV) has increased noticeably since the outbreak in the Americas in 2015, when the illness was associated with congenital disorders. Although there is evidence of sexual transmission of the virus, the mosquito Aedes aegypti is believed to be the main vector for transmi...
Published in: | PLOS Neglected Tropical Diseases |
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Online Access: | https://doi.org/10.1371/journal.pntd.0007433 https://doaj.org/article/5e2476a45a8749e8801a00bc570b52a3 |
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ftdoajarticles:oai:doaj.org/article:5e2476a45a8749e8801a00bc570b52a3 2023-05-15T15:16:26+02:00 Vector competence of Aedes aegypti for different strains of Zika virus in Argentina. Melisa Berenice Bonica Silvina Goenaga María Laura Martin Mariel Feroci Victoria Luppo Evangelina Muttis Cintia Fabbri María Alejandra Morales Delia Enria María Victoria Micieli Silvana Levis 2019-06-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0007433 https://doaj.org/article/5e2476a45a8749e8801a00bc570b52a3 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0007433 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0007433 https://doaj.org/article/5e2476a45a8749e8801a00bc570b52a3 PLoS Neglected Tropical Diseases, Vol 13, Iss 6, p e0007433 (2019) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2019 ftdoajarticles https://doi.org/10.1371/journal.pntd.0007433 2022-12-31T06:00:46Z The importance of Zika virus (ZIKV) has increased noticeably since the outbreak in the Americas in 2015, when the illness was associated with congenital disorders. Although there is evidence of sexual transmission of the virus, the mosquito Aedes aegypti is believed to be the main vector for transmission to humans. This species of mosquito has not only been found naturally infected with ZIKV, but also has been the subject of study in many vector competence assays that employ different strains of ZIKV around the world. In Argentina, the first case was reported in February 2016 and a total of 278 autochthonous cases have since been confirmed, however, ZIKV virus has not been isolated from any mosquito species yet in Argentina. In order to elucidate if Argentinian Ae. aegypti populations could be a possible vector of ZIKV, we conducted vector competence studies that involved a local strain of ZIKV from Chaco province, and a Venezuelan strain obtained from an imported case. For this purpose, Ae. aegypti adults from the temperate area of Argentina (Buenos Aires province) were fed with infected blood. Body, legs and saliva were harvested and tested by plaque titration on plates of Vero cells for ZIKV at 7, 11 and 14 days post infection (DPI) in order to calculate infection, transmission, and dissemination rates, respectively. Both strains were able to infect mosquitoes at all DPIs, whereas dissemination and transmission were observed at all DPIs for the Argentinian strain but only at 14 DPI for the Venezuelan strain. This study proves the ability of Ae. aegypti mosquitoes from Argentina to become infected with two different strains of ZIKV, both belonging to the Asian lineage, and that the virus can disseminate to the legs and salivary glands. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Argentina Chaco ENVELOPE(-60.583,-60.583,-63.033,-63.033) PLOS Neglected Tropical Diseases 13 6 e0007433 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Melisa Berenice Bonica Silvina Goenaga María Laura Martin Mariel Feroci Victoria Luppo Evangelina Muttis Cintia Fabbri María Alejandra Morales Delia Enria María Victoria Micieli Silvana Levis Vector competence of Aedes aegypti for different strains of Zika virus in Argentina. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
The importance of Zika virus (ZIKV) has increased noticeably since the outbreak in the Americas in 2015, when the illness was associated with congenital disorders. Although there is evidence of sexual transmission of the virus, the mosquito Aedes aegypti is believed to be the main vector for transmission to humans. This species of mosquito has not only been found naturally infected with ZIKV, but also has been the subject of study in many vector competence assays that employ different strains of ZIKV around the world. In Argentina, the first case was reported in February 2016 and a total of 278 autochthonous cases have since been confirmed, however, ZIKV virus has not been isolated from any mosquito species yet in Argentina. In order to elucidate if Argentinian Ae. aegypti populations could be a possible vector of ZIKV, we conducted vector competence studies that involved a local strain of ZIKV from Chaco province, and a Venezuelan strain obtained from an imported case. For this purpose, Ae. aegypti adults from the temperate area of Argentina (Buenos Aires province) were fed with infected blood. Body, legs and saliva were harvested and tested by plaque titration on plates of Vero cells for ZIKV at 7, 11 and 14 days post infection (DPI) in order to calculate infection, transmission, and dissemination rates, respectively. Both strains were able to infect mosquitoes at all DPIs, whereas dissemination and transmission were observed at all DPIs for the Argentinian strain but only at 14 DPI for the Venezuelan strain. This study proves the ability of Ae. aegypti mosquitoes from Argentina to become infected with two different strains of ZIKV, both belonging to the Asian lineage, and that the virus can disseminate to the legs and salivary glands. |
format |
Article in Journal/Newspaper |
author |
Melisa Berenice Bonica Silvina Goenaga María Laura Martin Mariel Feroci Victoria Luppo Evangelina Muttis Cintia Fabbri María Alejandra Morales Delia Enria María Victoria Micieli Silvana Levis |
author_facet |
Melisa Berenice Bonica Silvina Goenaga María Laura Martin Mariel Feroci Victoria Luppo Evangelina Muttis Cintia Fabbri María Alejandra Morales Delia Enria María Victoria Micieli Silvana Levis |
author_sort |
Melisa Berenice Bonica |
title |
Vector competence of Aedes aegypti for different strains of Zika virus in Argentina. |
title_short |
Vector competence of Aedes aegypti for different strains of Zika virus in Argentina. |
title_full |
Vector competence of Aedes aegypti for different strains of Zika virus in Argentina. |
title_fullStr |
Vector competence of Aedes aegypti for different strains of Zika virus in Argentina. |
title_full_unstemmed |
Vector competence of Aedes aegypti for different strains of Zika virus in Argentina. |
title_sort |
vector competence of aedes aegypti for different strains of zika virus in argentina. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2019 |
url |
https://doi.org/10.1371/journal.pntd.0007433 https://doaj.org/article/5e2476a45a8749e8801a00bc570b52a3 |
long_lat |
ENVELOPE(-60.583,-60.583,-63.033,-63.033) |
geographic |
Arctic Argentina Chaco |
geographic_facet |
Arctic Argentina Chaco |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 13, Iss 6, p e0007433 (2019) |
op_relation |
https://doi.org/10.1371/journal.pntd.0007433 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0007433 https://doaj.org/article/5e2476a45a8749e8801a00bc570b52a3 |
op_doi |
https://doi.org/10.1371/journal.pntd.0007433 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
13 |
container_issue |
6 |
container_start_page |
e0007433 |
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1766346734321008640 |