Long-term impact of a ten-year intervention program on human and canine Trypanosoma cruzi infection in the Argentine Chaco.
Background Interruption of domestic vector-borne transmission of Trypanosoma cruzi is still an unmet goal in several American countries. In 2007 we launched a long-term intervention program aimed to suppress house infestation with the main domestic vector in southern South America (Triatoma infestan...
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Online Access: | https://doi.org/10.1371/journal.pntd.0009389 https://doaj.org/article/5df0d78cdb0f4f038d5b9f285aedfdd3 |
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ftdoajarticles:oai:doaj.org/article:5df0d78cdb0f4f038d5b9f285aedfdd3 2023-05-15T15:18:20+02:00 Long-term impact of a ten-year intervention program on human and canine Trypanosoma cruzi infection in the Argentine Chaco. Marta Victoria Cardinal Gustavo Fabián Enriquez Natalia Paula Macchiaverna Hernán Darío Argibay María Del Pilar Fernández Alejandra Alvedro María Sol Gaspe Ricardo Esteban Gürtler 2021-05-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0009389 https://doaj.org/article/5df0d78cdb0f4f038d5b9f285aedfdd3 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0009389 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0009389 https://doaj.org/article/5df0d78cdb0f4f038d5b9f285aedfdd3 PLoS Neglected Tropical Diseases, Vol 15, Iss 5, p e0009389 (2021) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2021 ftdoajarticles https://doi.org/10.1371/journal.pntd.0009389 2022-12-31T11:01:42Z Background Interruption of domestic vector-borne transmission of Trypanosoma cruzi is still an unmet goal in several American countries. In 2007 we launched a long-term intervention program aimed to suppress house infestation with the main domestic vector in southern South America (Triatoma infestans) and domestic transmission in Pampa del Indio, a resource-constrained, hyperendemic municipality with 1446 rural houses inhabited by Creole and indigenous people, in the Argentine Chaco ecoregion. Here, we assessed whether the 10-year insecticide-based program combined with community mobilization blocked vector-borne domestic transmission of T. cruzi to humans and dogs. Methods We carried out two municipality-wide, cross-sectional serosurveys of humans and dogs (considered sentinel animals) during 2016-2017 to compare with baseline data. We used a risk-stratified random sampling design to select 273 study houses; 410 people from 180 households and 492 dogs from 151 houses were examined for antibodies to T. cruzi using at least two serological methods. Results The seroprevalence of T. cruzi in children aged <16 years was 2.5% in 2017 (i.e., 4- to 11-fold lower than before interventions). The mean annual force of child infection (λ) sharply decreased from 2.18 to 0.34 per 100 person-years in 2017. One of 102 children born after interventions was seropositive for T. cruzi; he had lifetime residence in an apparently uninfested house, no outside travel history, and his mother was T. cruzi-seropositive. No incident case was detected among 114 seronegative people of all ages re-examined serologically. Dog seroprevalence was 3.05%. Among native dogs, λ in 2016 (1.21 per 100 dog-years) was 5 times lower than at program onset. Six native adult dogs born after interventions and with stable lifetime residence were T. cruzi-seropositive: three had exposure to T. infestans at their houses and one was an incident case. Conclusions These results support the interruption of vector-borne transmission of T. cruzi to humans in rural ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Argentine Chaco ENVELOPE(-60.583,-60.583,-63.033,-63.033) Pampa ENVELOPE(-57.216,-57.216,-63.883,-63.883) PLOS Neglected Tropical Diseases 15 5 e0009389 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Marta Victoria Cardinal Gustavo Fabián Enriquez Natalia Paula Macchiaverna Hernán Darío Argibay María Del Pilar Fernández Alejandra Alvedro María Sol Gaspe Ricardo Esteban Gürtler Long-term impact of a ten-year intervention program on human and canine Trypanosoma cruzi infection in the Argentine Chaco. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Background Interruption of domestic vector-borne transmission of Trypanosoma cruzi is still an unmet goal in several American countries. In 2007 we launched a long-term intervention program aimed to suppress house infestation with the main domestic vector in southern South America (Triatoma infestans) and domestic transmission in Pampa del Indio, a resource-constrained, hyperendemic municipality with 1446 rural houses inhabited by Creole and indigenous people, in the Argentine Chaco ecoregion. Here, we assessed whether the 10-year insecticide-based program combined with community mobilization blocked vector-borne domestic transmission of T. cruzi to humans and dogs. Methods We carried out two municipality-wide, cross-sectional serosurveys of humans and dogs (considered sentinel animals) during 2016-2017 to compare with baseline data. We used a risk-stratified random sampling design to select 273 study houses; 410 people from 180 households and 492 dogs from 151 houses were examined for antibodies to T. cruzi using at least two serological methods. Results The seroprevalence of T. cruzi in children aged <16 years was 2.5% in 2017 (i.e., 4- to 11-fold lower than before interventions). The mean annual force of child infection (λ) sharply decreased from 2.18 to 0.34 per 100 person-years in 2017. One of 102 children born after interventions was seropositive for T. cruzi; he had lifetime residence in an apparently uninfested house, no outside travel history, and his mother was T. cruzi-seropositive. No incident case was detected among 114 seronegative people of all ages re-examined serologically. Dog seroprevalence was 3.05%. Among native dogs, λ in 2016 (1.21 per 100 dog-years) was 5 times lower than at program onset. Six native adult dogs born after interventions and with stable lifetime residence were T. cruzi-seropositive: three had exposure to T. infestans at their houses and one was an incident case. Conclusions These results support the interruption of vector-borne transmission of T. cruzi to humans in rural ... |
format |
Article in Journal/Newspaper |
author |
Marta Victoria Cardinal Gustavo Fabián Enriquez Natalia Paula Macchiaverna Hernán Darío Argibay María Del Pilar Fernández Alejandra Alvedro María Sol Gaspe Ricardo Esteban Gürtler |
author_facet |
Marta Victoria Cardinal Gustavo Fabián Enriquez Natalia Paula Macchiaverna Hernán Darío Argibay María Del Pilar Fernández Alejandra Alvedro María Sol Gaspe Ricardo Esteban Gürtler |
author_sort |
Marta Victoria Cardinal |
title |
Long-term impact of a ten-year intervention program on human and canine Trypanosoma cruzi infection in the Argentine Chaco. |
title_short |
Long-term impact of a ten-year intervention program on human and canine Trypanosoma cruzi infection in the Argentine Chaco. |
title_full |
Long-term impact of a ten-year intervention program on human and canine Trypanosoma cruzi infection in the Argentine Chaco. |
title_fullStr |
Long-term impact of a ten-year intervention program on human and canine Trypanosoma cruzi infection in the Argentine Chaco. |
title_full_unstemmed |
Long-term impact of a ten-year intervention program on human and canine Trypanosoma cruzi infection in the Argentine Chaco. |
title_sort |
long-term impact of a ten-year intervention program on human and canine trypanosoma cruzi infection in the argentine chaco. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2021 |
url |
https://doi.org/10.1371/journal.pntd.0009389 https://doaj.org/article/5df0d78cdb0f4f038d5b9f285aedfdd3 |
long_lat |
ENVELOPE(-60.583,-60.583,-63.033,-63.033) ENVELOPE(-57.216,-57.216,-63.883,-63.883) |
geographic |
Arctic Argentine Chaco Pampa |
geographic_facet |
Arctic Argentine Chaco Pampa |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 15, Iss 5, p e0009389 (2021) |
op_relation |
https://doi.org/10.1371/journal.pntd.0009389 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0009389 https://doaj.org/article/5df0d78cdb0f4f038d5b9f285aedfdd3 |
op_doi |
https://doi.org/10.1371/journal.pntd.0009389 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
15 |
container_issue |
5 |
container_start_page |
e0009389 |
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1766348537684033536 |