A randomised, double-blind, controlled efficacy trial of the LiESP/QA-21 vaccine in naïve dogs exposed to two leishmania infantum transmission seasons.
Canine leishmaniasis is an important zoonosis caused by uncontrolled infection with Leishmania infantum, where an inappropriate immune response is not only responsible for permitting this intracellular parasite to multiply, but is also responsible for several of the pathological processes seen in th...
Published in: | PLoS Neglected Tropical Diseases |
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Online Access: | https://doi.org/10.1371/journal.pntd.0003213 https://doaj.org/article/5d8e8a94eeac4d2a897f0db5637cc23c |
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ftdoajarticles:oai:doaj.org/article:5d8e8a94eeac4d2a897f0db5637cc23c 2023-05-15T15:09:23+02:00 A randomised, double-blind, controlled efficacy trial of the LiESP/QA-21 vaccine in naïve dogs exposed to two leishmania infantum transmission seasons. Gaetano Oliva Javier Nieto Valentina Foglia Manzillo Silvia Cappiello Eleonora Fiorentino Trentina Di Muccio Aldo Scalone Javier Moreno Carmen Chicharro Eugenia Carrillo Therese Butaud Laurie Guegand Virginie Martin Anne-Marie Cuisinier David McGahie Sylvie Gueguen Carmen Cañavate Luigi Gradoni 2014-10-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0003213 https://doaj.org/article/5d8e8a94eeac4d2a897f0db5637cc23c EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC4191955?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0003213 https://doaj.org/article/5d8e8a94eeac4d2a897f0db5637cc23c PLoS Neglected Tropical Diseases, Vol 8, Iss 10, p e3213 (2014) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2014 ftdoajarticles https://doi.org/10.1371/journal.pntd.0003213 2022-12-31T15:20:11Z Canine leishmaniasis is an important zoonosis caused by uncontrolled infection with Leishmania infantum, where an inappropriate immune response is not only responsible for permitting this intracellular parasite to multiply, but is also responsible for several of the pathological processes seen in this disease. Effective canine vaccines are therefore a highly desirable prevention tool. In this randomised, double-blinded, controlled trial, the efficacy of the LiESP/QA-21 vaccine (CaniLeish, Virbac, France) was assessed by exposing 90 naïve dogs to natural L. infantum infection during 2 consecutive transmission seasons, in two highly endemic areas of the Mediterranean basin. Regular PCR, culture, serological and clinical examinations were performed, and the infection/disease status of the dogs was classified at each examination. The vaccine was well-tolerated, and provided a significant reduction in the risk of progressing to uncontrolled active infection (p = 0.025) or symptomatic disease (p = 0.046), with an efficacy of 68.4% and a protection rate of 92.7%. The probability of becoming PCR positive was similar between groups, but the probability of returning to a PCR negative condition was higher in the vaccinated group (p = 0.04). In conclusion, we confirmed the interest of using this vaccine as part of a comprehensive control program for canine leishmaniasis, and validated the use of a protocol based on regular in-depth assessments over time to assess the efficacy of a canine leishmaniasis vaccine. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 8 10 e3213 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Gaetano Oliva Javier Nieto Valentina Foglia Manzillo Silvia Cappiello Eleonora Fiorentino Trentina Di Muccio Aldo Scalone Javier Moreno Carmen Chicharro Eugenia Carrillo Therese Butaud Laurie Guegand Virginie Martin Anne-Marie Cuisinier David McGahie Sylvie Gueguen Carmen Cañavate Luigi Gradoni A randomised, double-blind, controlled efficacy trial of the LiESP/QA-21 vaccine in naïve dogs exposed to two leishmania infantum transmission seasons. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Canine leishmaniasis is an important zoonosis caused by uncontrolled infection with Leishmania infantum, where an inappropriate immune response is not only responsible for permitting this intracellular parasite to multiply, but is also responsible for several of the pathological processes seen in this disease. Effective canine vaccines are therefore a highly desirable prevention tool. In this randomised, double-blinded, controlled trial, the efficacy of the LiESP/QA-21 vaccine (CaniLeish, Virbac, France) was assessed by exposing 90 naïve dogs to natural L. infantum infection during 2 consecutive transmission seasons, in two highly endemic areas of the Mediterranean basin. Regular PCR, culture, serological and clinical examinations were performed, and the infection/disease status of the dogs was classified at each examination. The vaccine was well-tolerated, and provided a significant reduction in the risk of progressing to uncontrolled active infection (p = 0.025) or symptomatic disease (p = 0.046), with an efficacy of 68.4% and a protection rate of 92.7%. The probability of becoming PCR positive was similar between groups, but the probability of returning to a PCR negative condition was higher in the vaccinated group (p = 0.04). In conclusion, we confirmed the interest of using this vaccine as part of a comprehensive control program for canine leishmaniasis, and validated the use of a protocol based on regular in-depth assessments over time to assess the efficacy of a canine leishmaniasis vaccine. |
format |
Article in Journal/Newspaper |
author |
Gaetano Oliva Javier Nieto Valentina Foglia Manzillo Silvia Cappiello Eleonora Fiorentino Trentina Di Muccio Aldo Scalone Javier Moreno Carmen Chicharro Eugenia Carrillo Therese Butaud Laurie Guegand Virginie Martin Anne-Marie Cuisinier David McGahie Sylvie Gueguen Carmen Cañavate Luigi Gradoni |
author_facet |
Gaetano Oliva Javier Nieto Valentina Foglia Manzillo Silvia Cappiello Eleonora Fiorentino Trentina Di Muccio Aldo Scalone Javier Moreno Carmen Chicharro Eugenia Carrillo Therese Butaud Laurie Guegand Virginie Martin Anne-Marie Cuisinier David McGahie Sylvie Gueguen Carmen Cañavate Luigi Gradoni |
author_sort |
Gaetano Oliva |
title |
A randomised, double-blind, controlled efficacy trial of the LiESP/QA-21 vaccine in naïve dogs exposed to two leishmania infantum transmission seasons. |
title_short |
A randomised, double-blind, controlled efficacy trial of the LiESP/QA-21 vaccine in naïve dogs exposed to two leishmania infantum transmission seasons. |
title_full |
A randomised, double-blind, controlled efficacy trial of the LiESP/QA-21 vaccine in naïve dogs exposed to two leishmania infantum transmission seasons. |
title_fullStr |
A randomised, double-blind, controlled efficacy trial of the LiESP/QA-21 vaccine in naïve dogs exposed to two leishmania infantum transmission seasons. |
title_full_unstemmed |
A randomised, double-blind, controlled efficacy trial of the LiESP/QA-21 vaccine in naïve dogs exposed to two leishmania infantum transmission seasons. |
title_sort |
randomised, double-blind, controlled efficacy trial of the liesp/qa-21 vaccine in naïve dogs exposed to two leishmania infantum transmission seasons. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2014 |
url |
https://doi.org/10.1371/journal.pntd.0003213 https://doaj.org/article/5d8e8a94eeac4d2a897f0db5637cc23c |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 8, Iss 10, p e3213 (2014) |
op_relation |
http://europepmc.org/articles/PMC4191955?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0003213 https://doaj.org/article/5d8e8a94eeac4d2a897f0db5637cc23c |
op_doi |
https://doi.org/10.1371/journal.pntd.0003213 |
container_title |
PLoS Neglected Tropical Diseases |
container_volume |
8 |
container_issue |
10 |
container_start_page |
e3213 |
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1766340584062058496 |