Patterns of hepatitis B virus exposure and associated predictors in Vietnam: A crosssectional study
Objective: To examine the magnitude of isolated anti-HBc and other HBV serological patterns and associated predictors among adults seeking general health check-up at a large health center in Vietnam. Methods: All 564 outpatients seeking general health checkup between January 2016 and December 2016 w...
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ftdoajarticles:oai:doaj.org/article:5d85d3bb7dd246c9aa9a5064cebf544d 2023-05-15T15:12:32+02:00 Patterns of hepatitis B virus exposure and associated predictors in Vietnam: A crosssectional study Minh C Duong Phuc V.D. Le Oanh N.K. Pham Hien D.T. Pham Toan B Nguyen Hai T Phan 2020-01-01T00:00:00Z https://doi.org/10.4103/1995-7645.296721 https://doaj.org/article/5d85d3bb7dd246c9aa9a5064cebf544d EN eng Wolters Kluwer Medknow Publications http://www.apjtm.org/article.asp?issn=1995-7645;year=2020;volume=13;issue=12;spage=535;epage=541;aulast=Duong https://doaj.org/toc/2352-4146 2352-4146 doi:10.4103/1995-7645.296721 https://doaj.org/article/5d85d3bb7dd246c9aa9a5064cebf544d Asian Pacific Journal of Tropical Medicine, Vol 13, Iss 12, Pp 535-541 (2020) hbv vietnam predictors isolated anti-hbc seroprevalence Arctic medicine. Tropical medicine RC955-962 article 2020 ftdoajarticles https://doi.org/10.4103/1995-7645.296721 2022-12-31T12:08:54Z Objective: To examine the magnitude of isolated anti-HBc and other HBV serological patterns and associated predictors among adults seeking general health check-up at a large health center in Vietnam. Methods: All 564 outpatients seeking general health checkup between January 2016 and December 2016 were asked to undertake HBV surface antigen, surface antibody, IgG and IgM core antibody (anti-HBc total), platelet counts, and liver function testing. An administered questionnaire was used to collect information regarding demography, in-house sources of infection, lifestyle, health condition and treatment, and HBV vaccination. Results: Male gender (P=0.043), age (P=0.000), living in urban areas (P=0.040), HBV vaccination status (P=0.033), and ALT (P=0.040) were associated with isolated anti-HBc. HBV infection was associated with HBV vaccination status (P=0.001), ALT levels (P=0.010), AST levels (P=0.020), and platelet counts (P=0.007). Past/resolved HBV infection was associated with AST levels (P=0.005), ALT levels (P=0.014), and age (P=0.000). Conclusions: Isolated anti-HBc is quite prevalent. Predictors of isolated anti-HBc include male gender, living in rural areas, and HBV non-vaccination. The prevalence of isolated anti-HBc also increases with age. To timely detect occult HBV infection and prevent transmission, anti-HBc testing should be included in the health check-up for high risk individuals and screening program where HBV nucleic acid test is not available. To prevent transmission, clinicians need to pay more attention on those who are at risk of having isolated anti-HBc and closely follow-up patients with isolated anti-HBc and educate them about the prevention of HBV infection. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Medicine 13 12 535 |
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Directory of Open Access Journals: DOAJ Articles |
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hbv vietnam predictors isolated anti-hbc seroprevalence Arctic medicine. Tropical medicine RC955-962 |
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hbv vietnam predictors isolated anti-hbc seroprevalence Arctic medicine. Tropical medicine RC955-962 Minh C Duong Phuc V.D. Le Oanh N.K. Pham Hien D.T. Pham Toan B Nguyen Hai T Phan Patterns of hepatitis B virus exposure and associated predictors in Vietnam: A crosssectional study |
topic_facet |
hbv vietnam predictors isolated anti-hbc seroprevalence Arctic medicine. Tropical medicine RC955-962 |
description |
Objective: To examine the magnitude of isolated anti-HBc and other HBV serological patterns and associated predictors among adults seeking general health check-up at a large health center in Vietnam. Methods: All 564 outpatients seeking general health checkup between January 2016 and December 2016 were asked to undertake HBV surface antigen, surface antibody, IgG and IgM core antibody (anti-HBc total), platelet counts, and liver function testing. An administered questionnaire was used to collect information regarding demography, in-house sources of infection, lifestyle, health condition and treatment, and HBV vaccination. Results: Male gender (P=0.043), age (P=0.000), living in urban areas (P=0.040), HBV vaccination status (P=0.033), and ALT (P=0.040) were associated with isolated anti-HBc. HBV infection was associated with HBV vaccination status (P=0.001), ALT levels (P=0.010), AST levels (P=0.020), and platelet counts (P=0.007). Past/resolved HBV infection was associated with AST levels (P=0.005), ALT levels (P=0.014), and age (P=0.000). Conclusions: Isolated anti-HBc is quite prevalent. Predictors of isolated anti-HBc include male gender, living in rural areas, and HBV non-vaccination. The prevalence of isolated anti-HBc also increases with age. To timely detect occult HBV infection and prevent transmission, anti-HBc testing should be included in the health check-up for high risk individuals and screening program where HBV nucleic acid test is not available. To prevent transmission, clinicians need to pay more attention on those who are at risk of having isolated anti-HBc and closely follow-up patients with isolated anti-HBc and educate them about the prevention of HBV infection. |
format |
Article in Journal/Newspaper |
author |
Minh C Duong Phuc V.D. Le Oanh N.K. Pham Hien D.T. Pham Toan B Nguyen Hai T Phan |
author_facet |
Minh C Duong Phuc V.D. Le Oanh N.K. Pham Hien D.T. Pham Toan B Nguyen Hai T Phan |
author_sort |
Minh C Duong |
title |
Patterns of hepatitis B virus exposure and associated predictors in Vietnam: A crosssectional study |
title_short |
Patterns of hepatitis B virus exposure and associated predictors in Vietnam: A crosssectional study |
title_full |
Patterns of hepatitis B virus exposure and associated predictors in Vietnam: A crosssectional study |
title_fullStr |
Patterns of hepatitis B virus exposure and associated predictors in Vietnam: A crosssectional study |
title_full_unstemmed |
Patterns of hepatitis B virus exposure and associated predictors in Vietnam: A crosssectional study |
title_sort |
patterns of hepatitis b virus exposure and associated predictors in vietnam: a crosssectional study |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2020 |
url |
https://doi.org/10.4103/1995-7645.296721 https://doaj.org/article/5d85d3bb7dd246c9aa9a5064cebf544d |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Medicine, Vol 13, Iss 12, Pp 535-541 (2020) |
op_relation |
http://www.apjtm.org/article.asp?issn=1995-7645;year=2020;volume=13;issue=12;spage=535;epage=541;aulast=Duong https://doaj.org/toc/2352-4146 2352-4146 doi:10.4103/1995-7645.296721 https://doaj.org/article/5d85d3bb7dd246c9aa9a5064cebf544d |
op_doi |
https://doi.org/10.4103/1995-7645.296721 |
container_title |
Asian Pacific Journal of Tropical Medicine |
container_volume |
13 |
container_issue |
12 |
container_start_page |
535 |
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1766343203987914752 |