Evidence for a Direct Harmful Effect of Alcohol on Myocardial Health: A Large Cross‐Sectional Study of Consumption Patterns and Cardiovascular Disease Risk Biomarkers From Northwest Russia, 2015 to 2017
Background Alcohol drinking is an increasingly recognized risk factor for cardiovascular disease. However, there are few studies of the impact of harmful and hazardous drinking on biomarkers of myocardial health. We conducted a study in Russia to investigate the impact of heavy drinking on biomarker...
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ftdoajarticles:oai:doaj.org/article:5d3579b1daa24fc3bb2e38592199a977 2023-05-15T17:46:04+02:00 Evidence for a Direct Harmful Effect of Alcohol on Myocardial Health: A Large Cross‐Sectional Study of Consumption Patterns and Cardiovascular Disease Risk Biomarkers From Northwest Russia, 2015 to 2017 Olena Iakunchykova Maria Averina Alexander V. Kudryavtsev Tom Wilsgaard Andrey Soloviev Henrik Schirmer Sarah Cook David A. Leon 2020-01-01T00:00:00Z https://doi.org/10.1161/JAHA.119.014491 https://doaj.org/article/5d3579b1daa24fc3bb2e38592199a977 EN eng Wiley https://www.ahajournals.org/doi/10.1161/JAHA.119.014491 https://doaj.org/toc/2047-9980 doi:10.1161/JAHA.119.014491 2047-9980 https://doaj.org/article/5d3579b1daa24fc3bb2e38592199a977 Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 9, Iss 1 (2020) alcohol use CRP (C‐reactive protein) NT‐proBNP (N‐terminal pro‐B‐type natriuretic peptide) troponin T Diseases of the circulatory (Cardiovascular) system RC666-701 article 2020 ftdoajarticles https://doi.org/10.1161/JAHA.119.014491 2022-12-31T03:54:44Z Background Alcohol drinking is an increasingly recognized risk factor for cardiovascular disease. However, there are few studies of the impact of harmful and hazardous drinking on biomarkers of myocardial health. We conducted a study in Russia to investigate the impact of heavy drinking on biomarkers of cardiac damage and inflammation. Methods and Results The Know Your Heart study recruited a random sample of 2479 participants from the population of northwest Russia (general population) plus 278 patients (narcology clinic subsample) with alcohol problems. The general population sample was categorized into harmful drinkers, hazardous drinkers, nonproblem drinkers, and nondrinkers, according to self‐reported level of alcohol consumption, whereas the narcology clinic sample was treated as the separate group in the analysis. Measurements were made of the following: (1) high‐sensitivity cardiac troponin T, (2) NT‐proBNP (N‐terminal pro‐B‐type natriuretic peptide), and (3) hsCRP (high‐sensitivity C‐reactive protein). The narcology clinic subsample had the most extreme drinking pattern and the highest levels of all 3 biomarkers relative to nonproblem drinkers in the general population: high‐sensitivity cardiac troponin T was elevated by 10.3% (95% CI, 3.7%–17.4%), NT‐proBNP by 46.7% (95% CI, 26.8%–69.8%), and hsCRP by 69.2% (95% CI, 43%–100%). In the general population sample, NT‐proBNP was 31.5% (95% CI, 3.4%–67.2%) higher among harmful drinkers compared with nonproblem drinkers. Overall, NT‐proBNP and hsCRP increased with increasing intensity of alcohol exposure (test of trend P<0.001). Conclusions These results support the hypothesis that heavy alcohol drinking has an adverse effect on cardiac structure and function that may not be driven by atherosclerosis. Article in Journal/Newspaper Northwest Russia Directory of Open Access Journals: DOAJ Articles Journal of the American Heart Association 9 1 |
institution |
Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
alcohol use CRP (C‐reactive protein) NT‐proBNP (N‐terminal pro‐B‐type natriuretic peptide) troponin T Diseases of the circulatory (Cardiovascular) system RC666-701 |
spellingShingle |
alcohol use CRP (C‐reactive protein) NT‐proBNP (N‐terminal pro‐B‐type natriuretic peptide) troponin T Diseases of the circulatory (Cardiovascular) system RC666-701 Olena Iakunchykova Maria Averina Alexander V. Kudryavtsev Tom Wilsgaard Andrey Soloviev Henrik Schirmer Sarah Cook David A. Leon Evidence for a Direct Harmful Effect of Alcohol on Myocardial Health: A Large Cross‐Sectional Study of Consumption Patterns and Cardiovascular Disease Risk Biomarkers From Northwest Russia, 2015 to 2017 |
topic_facet |
alcohol use CRP (C‐reactive protein) NT‐proBNP (N‐terminal pro‐B‐type natriuretic peptide) troponin T Diseases of the circulatory (Cardiovascular) system RC666-701 |
description |
Background Alcohol drinking is an increasingly recognized risk factor for cardiovascular disease. However, there are few studies of the impact of harmful and hazardous drinking on biomarkers of myocardial health. We conducted a study in Russia to investigate the impact of heavy drinking on biomarkers of cardiac damage and inflammation. Methods and Results The Know Your Heart study recruited a random sample of 2479 participants from the population of northwest Russia (general population) plus 278 patients (narcology clinic subsample) with alcohol problems. The general population sample was categorized into harmful drinkers, hazardous drinkers, nonproblem drinkers, and nondrinkers, according to self‐reported level of alcohol consumption, whereas the narcology clinic sample was treated as the separate group in the analysis. Measurements were made of the following: (1) high‐sensitivity cardiac troponin T, (2) NT‐proBNP (N‐terminal pro‐B‐type natriuretic peptide), and (3) hsCRP (high‐sensitivity C‐reactive protein). The narcology clinic subsample had the most extreme drinking pattern and the highest levels of all 3 biomarkers relative to nonproblem drinkers in the general population: high‐sensitivity cardiac troponin T was elevated by 10.3% (95% CI, 3.7%–17.4%), NT‐proBNP by 46.7% (95% CI, 26.8%–69.8%), and hsCRP by 69.2% (95% CI, 43%–100%). In the general population sample, NT‐proBNP was 31.5% (95% CI, 3.4%–67.2%) higher among harmful drinkers compared with nonproblem drinkers. Overall, NT‐proBNP and hsCRP increased with increasing intensity of alcohol exposure (test of trend P<0.001). Conclusions These results support the hypothesis that heavy alcohol drinking has an adverse effect on cardiac structure and function that may not be driven by atherosclerosis. |
format |
Article in Journal/Newspaper |
author |
Olena Iakunchykova Maria Averina Alexander V. Kudryavtsev Tom Wilsgaard Andrey Soloviev Henrik Schirmer Sarah Cook David A. Leon |
author_facet |
Olena Iakunchykova Maria Averina Alexander V. Kudryavtsev Tom Wilsgaard Andrey Soloviev Henrik Schirmer Sarah Cook David A. Leon |
author_sort |
Olena Iakunchykova |
title |
Evidence for a Direct Harmful Effect of Alcohol on Myocardial Health: A Large Cross‐Sectional Study of Consumption Patterns and Cardiovascular Disease Risk Biomarkers From Northwest Russia, 2015 to 2017 |
title_short |
Evidence for a Direct Harmful Effect of Alcohol on Myocardial Health: A Large Cross‐Sectional Study of Consumption Patterns and Cardiovascular Disease Risk Biomarkers From Northwest Russia, 2015 to 2017 |
title_full |
Evidence for a Direct Harmful Effect of Alcohol on Myocardial Health: A Large Cross‐Sectional Study of Consumption Patterns and Cardiovascular Disease Risk Biomarkers From Northwest Russia, 2015 to 2017 |
title_fullStr |
Evidence for a Direct Harmful Effect of Alcohol on Myocardial Health: A Large Cross‐Sectional Study of Consumption Patterns and Cardiovascular Disease Risk Biomarkers From Northwest Russia, 2015 to 2017 |
title_full_unstemmed |
Evidence for a Direct Harmful Effect of Alcohol on Myocardial Health: A Large Cross‐Sectional Study of Consumption Patterns and Cardiovascular Disease Risk Biomarkers From Northwest Russia, 2015 to 2017 |
title_sort |
evidence for a direct harmful effect of alcohol on myocardial health: a large cross‐sectional study of consumption patterns and cardiovascular disease risk biomarkers from northwest russia, 2015 to 2017 |
publisher |
Wiley |
publishDate |
2020 |
url |
https://doi.org/10.1161/JAHA.119.014491 https://doaj.org/article/5d3579b1daa24fc3bb2e38592199a977 |
genre |
Northwest Russia |
genre_facet |
Northwest Russia |
op_source |
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 9, Iss 1 (2020) |
op_relation |
https://www.ahajournals.org/doi/10.1161/JAHA.119.014491 https://doaj.org/toc/2047-9980 doi:10.1161/JAHA.119.014491 2047-9980 https://doaj.org/article/5d3579b1daa24fc3bb2e38592199a977 |
op_doi |
https://doi.org/10.1161/JAHA.119.014491 |
container_title |
Journal of the American Heart Association |
container_volume |
9 |
container_issue |
1 |
_version_ |
1766149416234778624 |