Arm-in-cage testing of natural human-derived mosquito repellents
Abstract Background Individual human subjects are differentially attractive to mosquitoes and other biting insects. Previous investigations have demonstrated that this can be attributed partly to enhanced production of natural repellent chemicals by those individuals that attract few mosquitoes in t...
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ftdoajarticles:oai:doaj.org/article:5d2a883a7523446382aa5175eaa4fb89 2023-05-15T15:15:52+02:00 Arm-in-cage testing of natural human-derived mosquito repellents Logan James G Stanczyk Nina M Hassanali Ahmed Kemei Joshua Santana Antônio EG Ribeiro Karlos AL Pickett John A Mordue (Luntz) A Jennifer 2010-08-01T00:00:00Z https://doi.org/10.1186/1475-2875-9-239 https://doaj.org/article/5d2a883a7523446382aa5175eaa4fb89 EN eng BMC http://www.malariajournal.com/content/9/1/239 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-9-239 1475-2875 https://doaj.org/article/5d2a883a7523446382aa5175eaa4fb89 Malaria Journal, Vol 9, Iss 1, p 239 (2010) Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2010 ftdoajarticles https://doi.org/10.1186/1475-2875-9-239 2022-12-31T08:53:06Z Abstract Background Individual human subjects are differentially attractive to mosquitoes and other biting insects. Previous investigations have demonstrated that this can be attributed partly to enhanced production of natural repellent chemicals by those individuals that attract few mosquitoes in the laboratory. The most important compounds in this respect include three aldehydes, octanal, nonanal and decanal, and two ketones, 6-methyl-5-hepten-2-one and geranylacetone [( E )-6,10-dimethylundeca-5,9-dien-2-one]. In olfactometer trials, these compounds interfered with attraction of mosquitoes to a host and consequently show promise as novel mosquito repellents. Methods To test whether these chemicals could provide protection against mosquitoes, laboratory repellency trials were carried out to test the chemicals individually at different concentrations and in different mixtures and ratios with three major disease vectors: Anopheles gambiae , Culex quinquefasciatus and Aedes aegypti . Results Up to 100% repellency was achieved depending on the type of repellent compound tested, the concentration and the relative composition of the mixture. The greatest effect was observed by mixing together two compounds, 6-methyl-5-hepten-2-one and geranylacetone in a 1:1 ratio. This mixture exceeded the repellency of DEET when presented at low concentrations. The repellent effect of this mixture was maintained over several hours. Altering the ratio of these compounds significantly affected the behavioural response of the mosquitoes, providing evidence for the ability of mosquitoes to detect and respond to specific mixtures and ratios of natural repellent compounds that are associated with host location. Conclusion The optimum mixture of 6-methyl-5-hepten-2-one and geranylacetone was a 1:1 ratio and this provided the most effective protection against all species of mosquito tested. With further improvements in formulation, selected blends of these compounds have the potential to be exploited and developed as human-derived novel ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 9 1 |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Logan James G Stanczyk Nina M Hassanali Ahmed Kemei Joshua Santana Antônio EG Ribeiro Karlos AL Pickett John A Mordue (Luntz) A Jennifer Arm-in-cage testing of natural human-derived mosquito repellents |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Individual human subjects are differentially attractive to mosquitoes and other biting insects. Previous investigations have demonstrated that this can be attributed partly to enhanced production of natural repellent chemicals by those individuals that attract few mosquitoes in the laboratory. The most important compounds in this respect include three aldehydes, octanal, nonanal and decanal, and two ketones, 6-methyl-5-hepten-2-one and geranylacetone [( E )-6,10-dimethylundeca-5,9-dien-2-one]. In olfactometer trials, these compounds interfered with attraction of mosquitoes to a host and consequently show promise as novel mosquito repellents. Methods To test whether these chemicals could provide protection against mosquitoes, laboratory repellency trials were carried out to test the chemicals individually at different concentrations and in different mixtures and ratios with three major disease vectors: Anopheles gambiae , Culex quinquefasciatus and Aedes aegypti . Results Up to 100% repellency was achieved depending on the type of repellent compound tested, the concentration and the relative composition of the mixture. The greatest effect was observed by mixing together two compounds, 6-methyl-5-hepten-2-one and geranylacetone in a 1:1 ratio. This mixture exceeded the repellency of DEET when presented at low concentrations. The repellent effect of this mixture was maintained over several hours. Altering the ratio of these compounds significantly affected the behavioural response of the mosquitoes, providing evidence for the ability of mosquitoes to detect and respond to specific mixtures and ratios of natural repellent compounds that are associated with host location. Conclusion The optimum mixture of 6-methyl-5-hepten-2-one and geranylacetone was a 1:1 ratio and this provided the most effective protection against all species of mosquito tested. With further improvements in formulation, selected blends of these compounds have the potential to be exploited and developed as human-derived novel ... |
format |
Article in Journal/Newspaper |
author |
Logan James G Stanczyk Nina M Hassanali Ahmed Kemei Joshua Santana Antônio EG Ribeiro Karlos AL Pickett John A Mordue (Luntz) A Jennifer |
author_facet |
Logan James G Stanczyk Nina M Hassanali Ahmed Kemei Joshua Santana Antônio EG Ribeiro Karlos AL Pickett John A Mordue (Luntz) A Jennifer |
author_sort |
Logan James G |
title |
Arm-in-cage testing of natural human-derived mosquito repellents |
title_short |
Arm-in-cage testing of natural human-derived mosquito repellents |
title_full |
Arm-in-cage testing of natural human-derived mosquito repellents |
title_fullStr |
Arm-in-cage testing of natural human-derived mosquito repellents |
title_full_unstemmed |
Arm-in-cage testing of natural human-derived mosquito repellents |
title_sort |
arm-in-cage testing of natural human-derived mosquito repellents |
publisher |
BMC |
publishDate |
2010 |
url |
https://doi.org/10.1186/1475-2875-9-239 https://doaj.org/article/5d2a883a7523446382aa5175eaa4fb89 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 9, Iss 1, p 239 (2010) |
op_relation |
http://www.malariajournal.com/content/9/1/239 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-9-239 1475-2875 https://doaj.org/article/5d2a883a7523446382aa5175eaa4fb89 |
op_doi |
https://doi.org/10.1186/1475-2875-9-239 |
container_title |
Malaria Journal |
container_volume |
9 |
container_issue |
1 |
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1766346201181978624 |