Comparative effectiveness of single and dual rapid diagnostic tests for syphilis and HIV in antenatal care services in Colombia
ABSTRACT Objective To assess the effectiveness of a dual rapid test compared to a single rapid test for syphilis and HIV screening. Methods A cluster-randomized open-label clinical trial was performed in 12 public antenatal care (ANC) centers in the cities of Bogotá and Cali, Colombia. Pregnant wome...
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ftdoajarticles:oai:doaj.org/article:5d25b1acc4704c5580605b4a35dd6239 2023-05-15T15:17:20+02:00 Comparative effectiveness of single and dual rapid diagnostic tests for syphilis and HIV in antenatal care services in Colombia Hernando Guillermo Gaitán-Duarte Lori Newman Maura Laverty Ndema Abu Habib Lina María González-Gordon Edith Ángel-Müller Catleya Abella Esther Cristina Barros Carlos Rincón Sidia Caicedo Bertha Gómez Freddy Pérez https://doaj.org/article/5d25b1acc4704c5580605b4a35dd6239 EN ES PT eng spa por Pan American Health Organization http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S1020-49892016001200455&lng=en&tlng=en https://doaj.org/toc/1680-5348 1680-5348 https://doaj.org/article/5d25b1acc4704c5580605b4a35dd6239 Revista Panamericana de Salud Pública, Vol 40, Iss 6, Pp 455-461 VIH sífilis mujeres embarazadas pruebas en el punto de atención efectividad aceptación de la atención de salud Colombia Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article ftdoajarticles 2022-12-31T00:27:01Z ABSTRACT Objective To assess the effectiveness of a dual rapid test compared to a single rapid test for syphilis and HIV screening. Methods A cluster-randomized open-label clinical trial was performed in 12 public antenatal care (ANC) centers in the cities of Bogotá and Cali, Colombia. Pregnant women who were over 14 years of age at their first antenatal visit and who had not been previously tested for HIV and syphilis during the current pregnancy were included. Pregnant women were randomized to single HIV and single syphilis rapid diagnostic tests (Arm A) or to dual HIV and syphilis rapid diagnostic tests (Arm B). The four main outcomes measured were: (1) acceptability of the test, (2) uptake in testing, (3) treatment on the same day (that is, timely treatment), and (4) treatment at any time for positive rapid test cases. Bivariate and multivariate analyses were calculated to adjust for the clustering effect and the period. Results A total of 1 048 patients were analyzed in Arm A, and 1 166 in Arm B. Acceptability of the rapid tests was 99.8% in Arm A and 99.6% in Arm B. The prevalence of positive rapid tests was 2.21% for syphilis and 0.36% for HIV. Timely treatment was provided to 20 of 29 patients (69%) in Arm A and 16 of 20 patients (80%) in Arm B (relative risk (RR), 1.10; 95% confidence interval (CI): (1.00 −1.20). Treatment at any time was given to 24 of 29 patients (83%) in Arm A and to 20 of 20 (100%) in Arm B (RR, 1.11; 95% CI: 1.01−1.22). Conclusions There were no differences in patient acceptability, testing and timely treatment between dual rapid tests and single rapid tests for HIV and syphilis screening in the ANC centers. Same-day treatment depends also on the interpretation of and confidence in the results by the health providers. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English Spanish Portuguese |
topic |
VIH sífilis mujeres embarazadas pruebas en el punto de atención efectividad aceptación de la atención de salud Colombia Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
VIH sífilis mujeres embarazadas pruebas en el punto de atención efectividad aceptación de la atención de salud Colombia Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Hernando Guillermo Gaitán-Duarte Lori Newman Maura Laverty Ndema Abu Habib Lina María González-Gordon Edith Ángel-Müller Catleya Abella Esther Cristina Barros Carlos Rincón Sidia Caicedo Bertha Gómez Freddy Pérez Comparative effectiveness of single and dual rapid diagnostic tests for syphilis and HIV in antenatal care services in Colombia |
topic_facet |
VIH sífilis mujeres embarazadas pruebas en el punto de atención efectividad aceptación de la atención de salud Colombia Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
ABSTRACT Objective To assess the effectiveness of a dual rapid test compared to a single rapid test for syphilis and HIV screening. Methods A cluster-randomized open-label clinical trial was performed in 12 public antenatal care (ANC) centers in the cities of Bogotá and Cali, Colombia. Pregnant women who were over 14 years of age at their first antenatal visit and who had not been previously tested for HIV and syphilis during the current pregnancy were included. Pregnant women were randomized to single HIV and single syphilis rapid diagnostic tests (Arm A) or to dual HIV and syphilis rapid diagnostic tests (Arm B). The four main outcomes measured were: (1) acceptability of the test, (2) uptake in testing, (3) treatment on the same day (that is, timely treatment), and (4) treatment at any time for positive rapid test cases. Bivariate and multivariate analyses were calculated to adjust for the clustering effect and the period. Results A total of 1 048 patients were analyzed in Arm A, and 1 166 in Arm B. Acceptability of the rapid tests was 99.8% in Arm A and 99.6% in Arm B. The prevalence of positive rapid tests was 2.21% for syphilis and 0.36% for HIV. Timely treatment was provided to 20 of 29 patients (69%) in Arm A and 16 of 20 patients (80%) in Arm B (relative risk (RR), 1.10; 95% confidence interval (CI): (1.00 −1.20). Treatment at any time was given to 24 of 29 patients (83%) in Arm A and to 20 of 20 (100%) in Arm B (RR, 1.11; 95% CI: 1.01−1.22). Conclusions There were no differences in patient acceptability, testing and timely treatment between dual rapid tests and single rapid tests for HIV and syphilis screening in the ANC centers. Same-day treatment depends also on the interpretation of and confidence in the results by the health providers. |
format |
Article in Journal/Newspaper |
author |
Hernando Guillermo Gaitán-Duarte Lori Newman Maura Laverty Ndema Abu Habib Lina María González-Gordon Edith Ángel-Müller Catleya Abella Esther Cristina Barros Carlos Rincón Sidia Caicedo Bertha Gómez Freddy Pérez |
author_facet |
Hernando Guillermo Gaitán-Duarte Lori Newman Maura Laverty Ndema Abu Habib Lina María González-Gordon Edith Ángel-Müller Catleya Abella Esther Cristina Barros Carlos Rincón Sidia Caicedo Bertha Gómez Freddy Pérez |
author_sort |
Hernando Guillermo Gaitán-Duarte |
title |
Comparative effectiveness of single and dual rapid diagnostic tests for syphilis and HIV in antenatal care services in Colombia |
title_short |
Comparative effectiveness of single and dual rapid diagnostic tests for syphilis and HIV in antenatal care services in Colombia |
title_full |
Comparative effectiveness of single and dual rapid diagnostic tests for syphilis and HIV in antenatal care services in Colombia |
title_fullStr |
Comparative effectiveness of single and dual rapid diagnostic tests for syphilis and HIV in antenatal care services in Colombia |
title_full_unstemmed |
Comparative effectiveness of single and dual rapid diagnostic tests for syphilis and HIV in antenatal care services in Colombia |
title_sort |
comparative effectiveness of single and dual rapid diagnostic tests for syphilis and hiv in antenatal care services in colombia |
publisher |
Pan American Health Organization |
url |
https://doaj.org/article/5d25b1acc4704c5580605b4a35dd6239 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista Panamericana de Salud Pública, Vol 40, Iss 6, Pp 455-461 |
op_relation |
http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S1020-49892016001200455&lng=en&tlng=en https://doaj.org/toc/1680-5348 1680-5348 https://doaj.org/article/5d25b1acc4704c5580605b4a35dd6239 |
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1766347575432052736 |