Epidemiology of dengue virus in Iquitos, Peru 1999 to 2005: interepidemic and epidemic patterns of transmission.
Comprehensive, longitudinal field studies that monitor both disease and vector populations for dengue viruses are urgently needed as a pre-requisite for developing locally adaptable prevention programs or to appropriately test and license new vaccines.We report the results from such a study spanning...
Published in: | PLoS Neglected Tropical Diseases |
---|---|
Main Authors: | , , , , , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Public Library of Science (PLoS)
2010
|
Subjects: | |
Online Access: | https://doi.org/10.1371/journal.pntd.0000670 https://doaj.org/article/5d1f98b5035f4941bbc68acf581deaa9 |
id |
ftdoajarticles:oai:doaj.org/article:5d1f98b5035f4941bbc68acf581deaa9 |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:5d1f98b5035f4941bbc68acf581deaa9 2023-05-15T15:11:49+02:00 Epidemiology of dengue virus in Iquitos, Peru 1999 to 2005: interepidemic and epidemic patterns of transmission. Amy C Morrison Sharon L Minnick Claudio Rocha Brett M Forshey Steven T Stoddard Arthur Getis Dana A Focks Kevin L Russell James G Olson Patrick J Blair Douglas M Watts Moises Sihuincha Thomas W Scott Tadeusz J Kochel 2010-05-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0000670 https://doaj.org/article/5d1f98b5035f4941bbc68acf581deaa9 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC2864256?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0000670 https://doaj.org/article/5d1f98b5035f4941bbc68acf581deaa9 PLoS Neglected Tropical Diseases, Vol 4, Iss 5, p e670 (2010) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2010 ftdoajarticles https://doi.org/10.1371/journal.pntd.0000670 2022-12-31T01:33:05Z Comprehensive, longitudinal field studies that monitor both disease and vector populations for dengue viruses are urgently needed as a pre-requisite for developing locally adaptable prevention programs or to appropriately test and license new vaccines.We report the results from such a study spanning 5 years in the Amazonian city of Iquitos, Peru where DENV infection was monitored serologically among approximately 2,400 members of a neighborhood-based cohort and through school-based absenteeism surveillance for active febrile illness among a subset of this cohort. At baseline, 80% of the study population had DENV antibodies, seroprevalence increased with age, and significant geographic variation was observed, with neighborhood-specific age-adjusted rates ranging from 67.1 to 89.9%. During the first 15 months, when DENV-1 and DENV-2 were co-circulating, population-based incidence rates ranged from 2-3 infections/100 person-years (p-years). The introduction of DENV-3 during the last half of 2001 was characterized by 3 distinct periods: amplification over at least 5-6 months, replacement of previously circulating serotypes, and epidemic transmission when incidence peaked at 89 infections/100 p-years.Neighborhood-specific baseline seroprevalence rates were not predictive of geographic incidence patterns prior to the DENV-3 introduction, but were closely mirrored during the invasion of this serotype. Transmission varied geographically, with peak incidence occurring at different times among the 8 geographic zones in approximately 16 km(2) of the city. The lag from novel serotype introduction to epidemic transmission and knowledge of spatially explicit areas of elevated risk should be considered for more effective application of limited resources for dengue prevention. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 4 5 e670 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Amy C Morrison Sharon L Minnick Claudio Rocha Brett M Forshey Steven T Stoddard Arthur Getis Dana A Focks Kevin L Russell James G Olson Patrick J Blair Douglas M Watts Moises Sihuincha Thomas W Scott Tadeusz J Kochel Epidemiology of dengue virus in Iquitos, Peru 1999 to 2005: interepidemic and epidemic patterns of transmission. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Comprehensive, longitudinal field studies that monitor both disease and vector populations for dengue viruses are urgently needed as a pre-requisite for developing locally adaptable prevention programs or to appropriately test and license new vaccines.We report the results from such a study spanning 5 years in the Amazonian city of Iquitos, Peru where DENV infection was monitored serologically among approximately 2,400 members of a neighborhood-based cohort and through school-based absenteeism surveillance for active febrile illness among a subset of this cohort. At baseline, 80% of the study population had DENV antibodies, seroprevalence increased with age, and significant geographic variation was observed, with neighborhood-specific age-adjusted rates ranging from 67.1 to 89.9%. During the first 15 months, when DENV-1 and DENV-2 were co-circulating, population-based incidence rates ranged from 2-3 infections/100 person-years (p-years). The introduction of DENV-3 during the last half of 2001 was characterized by 3 distinct periods: amplification over at least 5-6 months, replacement of previously circulating serotypes, and epidemic transmission when incidence peaked at 89 infections/100 p-years.Neighborhood-specific baseline seroprevalence rates were not predictive of geographic incidence patterns prior to the DENV-3 introduction, but were closely mirrored during the invasion of this serotype. Transmission varied geographically, with peak incidence occurring at different times among the 8 geographic zones in approximately 16 km(2) of the city. The lag from novel serotype introduction to epidemic transmission and knowledge of spatially explicit areas of elevated risk should be considered for more effective application of limited resources for dengue prevention. |
format |
Article in Journal/Newspaper |
author |
Amy C Morrison Sharon L Minnick Claudio Rocha Brett M Forshey Steven T Stoddard Arthur Getis Dana A Focks Kevin L Russell James G Olson Patrick J Blair Douglas M Watts Moises Sihuincha Thomas W Scott Tadeusz J Kochel |
author_facet |
Amy C Morrison Sharon L Minnick Claudio Rocha Brett M Forshey Steven T Stoddard Arthur Getis Dana A Focks Kevin L Russell James G Olson Patrick J Blair Douglas M Watts Moises Sihuincha Thomas W Scott Tadeusz J Kochel |
author_sort |
Amy C Morrison |
title |
Epidemiology of dengue virus in Iquitos, Peru 1999 to 2005: interepidemic and epidemic patterns of transmission. |
title_short |
Epidemiology of dengue virus in Iquitos, Peru 1999 to 2005: interepidemic and epidemic patterns of transmission. |
title_full |
Epidemiology of dengue virus in Iquitos, Peru 1999 to 2005: interepidemic and epidemic patterns of transmission. |
title_fullStr |
Epidemiology of dengue virus in Iquitos, Peru 1999 to 2005: interepidemic and epidemic patterns of transmission. |
title_full_unstemmed |
Epidemiology of dengue virus in Iquitos, Peru 1999 to 2005: interepidemic and epidemic patterns of transmission. |
title_sort |
epidemiology of dengue virus in iquitos, peru 1999 to 2005: interepidemic and epidemic patterns of transmission. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2010 |
url |
https://doi.org/10.1371/journal.pntd.0000670 https://doaj.org/article/5d1f98b5035f4941bbc68acf581deaa9 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 4, Iss 5, p e670 (2010) |
op_relation |
http://europepmc.org/articles/PMC2864256?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0000670 https://doaj.org/article/5d1f98b5035f4941bbc68acf581deaa9 |
op_doi |
https://doi.org/10.1371/journal.pntd.0000670 |
container_title |
PLoS Neglected Tropical Diseases |
container_volume |
4 |
container_issue |
5 |
container_start_page |
e670 |
_version_ |
1766342606554398720 |