Identification of commonly regulated protein targets and molecular pathways in PC-3 and DU145 androgen-independent human prostate cancer cells treated with the curcumin analogue 1,5-bis(2-hydroxyphenyl)-1,4-pentadiene-3-one

• Published in: Asian Pacific Journal of Tropical Biomedicine
• Main Authors: Kamini Citalingam, Faridah Abas, Nordin H Lajis, Iekhsan Othman, Rakesh Naidu
• Format: Article in Journal/Newspaper
• Language: English
• Published: Wolters Kluwer Medknow Publications 2018
• Subjects: androgen-independent prostate cancer; diarylpentanoid; proteomics profiling; mass spectrometry; pathway analysis; Arctic medicine. Tropical medicine; RC955-962; Biology (General); QH301-705.5; Arctic; Tera
• Online Access: https://doi.org/10.4103/2221-1691.242291; https://doaj.org/article/5d1454a2d43447a4b1e564a123238ebb

Objective: To identify mutually regulated proteins in PC-3 and DU145 androgen-independent prostate cancer cell lines treated with 1,5-bis(2-hydroxyphenyl)-1,4-pentadiene-3-one (MS17), and to study the molecular pathways that contributed to the anticancer activity of MS17. Methods: PC-3 and DU145 cel...