Emergence of aph(3’)-VI and accumulation of aminoglycoside modifying enzyme genes in KPC-2-possessing Enterobacter aerogenes isolates from infections and colonization in patients from Recife-PE, Brazil
Abstract INTRODUCTION: The objective of this study was to characterize genes of aminoglycoside modifying enzymes (AMEs) in colonizing and infecting isolates of E. aerogenes harboring bla KPC from patients at a public hospital in Recife-PE, Brazil. METHODS: We analyzed 29 E. aerogenes clinical isolat...
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ftdoajarticles:oai:doaj.org/article:5cfd8e4e675948389758edd8a07ce018 2023-05-15T15:03:22+02:00 Emergence of aph(3’)-VI and accumulation of aminoglycoside modifying enzyme genes in KPC-2-possessing Enterobacter aerogenes isolates from infections and colonization in patients from Recife-PE, Brazil Elza Ferreira Firmo Adriane Borges Cabral Érica Maria de Oliveira Ana Catarina Souza Lopes https://doi.org/10.1590/0037-8682-0460-2018 https://doaj.org/article/5cfd8e4e675948389758edd8a07ce018 EN eng Sociedade Brasileira de Medicina Tropical (SBMT) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822019000100669&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/0037-8682-0460-2018 https://doaj.org/article/5cfd8e4e675948389758edd8a07ce018 Revista da Sociedade Brasileira de Medicina Tropical, Vol 52 Enterobacter aerogenes Aminoglycoside modifying enzymes Antimicrobial resistance KPC Arctic medicine. Tropical medicine RC955-962 article ftdoajarticles https://doi.org/10.1590/0037-8682-0460-2018 2022-12-31T02:44:20Z Abstract INTRODUCTION: The objective of this study was to characterize genes of aminoglycoside modifying enzymes (AMEs) in colonizing and infecting isolates of E. aerogenes harboring bla KPC from patients at a public hospital in Recife-PE, Brazil. METHODS: We analyzed 29 E. aerogenes clinical isolates resistant to aminoglycosides. AMEs genes were investigated by PCR and sequencing. RESULTS: Colonizing and infecting isolates mainly presented the genetic profiles aac(3)-IIa/aph(3’)-VI or ant(2”)-IIa/aph(3’)-VI. This is the first report of aph(3’)-VI in E. aerogenes harboring bla KPC in Brazil. CONCLUSIONS: The results highlight the importance in establishing rigorous methods for the surveillance of resistance genes, especially in colonized patients. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista da Sociedade Brasileira de Medicina Tropical 52 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
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Enterobacter aerogenes Aminoglycoside modifying enzymes Antimicrobial resistance KPC Arctic medicine. Tropical medicine RC955-962 |
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Enterobacter aerogenes Aminoglycoside modifying enzymes Antimicrobial resistance KPC Arctic medicine. Tropical medicine RC955-962 Elza Ferreira Firmo Adriane Borges Cabral Érica Maria de Oliveira Ana Catarina Souza Lopes Emergence of aph(3’)-VI and accumulation of aminoglycoside modifying enzyme genes in KPC-2-possessing Enterobacter aerogenes isolates from infections and colonization in patients from Recife-PE, Brazil |
topic_facet |
Enterobacter aerogenes Aminoglycoside modifying enzymes Antimicrobial resistance KPC Arctic medicine. Tropical medicine RC955-962 |
description |
Abstract INTRODUCTION: The objective of this study was to characterize genes of aminoglycoside modifying enzymes (AMEs) in colonizing and infecting isolates of E. aerogenes harboring bla KPC from patients at a public hospital in Recife-PE, Brazil. METHODS: We analyzed 29 E. aerogenes clinical isolates resistant to aminoglycosides. AMEs genes were investigated by PCR and sequencing. RESULTS: Colonizing and infecting isolates mainly presented the genetic profiles aac(3)-IIa/aph(3’)-VI or ant(2”)-IIa/aph(3’)-VI. This is the first report of aph(3’)-VI in E. aerogenes harboring bla KPC in Brazil. CONCLUSIONS: The results highlight the importance in establishing rigorous methods for the surveillance of resistance genes, especially in colonized patients. |
format |
Article in Journal/Newspaper |
author |
Elza Ferreira Firmo Adriane Borges Cabral Érica Maria de Oliveira Ana Catarina Souza Lopes |
author_facet |
Elza Ferreira Firmo Adriane Borges Cabral Érica Maria de Oliveira Ana Catarina Souza Lopes |
author_sort |
Elza Ferreira Firmo |
title |
Emergence of aph(3’)-VI and accumulation of aminoglycoside modifying enzyme genes in KPC-2-possessing Enterobacter aerogenes isolates from infections and colonization in patients from Recife-PE, Brazil |
title_short |
Emergence of aph(3’)-VI and accumulation of aminoglycoside modifying enzyme genes in KPC-2-possessing Enterobacter aerogenes isolates from infections and colonization in patients from Recife-PE, Brazil |
title_full |
Emergence of aph(3’)-VI and accumulation of aminoglycoside modifying enzyme genes in KPC-2-possessing Enterobacter aerogenes isolates from infections and colonization in patients from Recife-PE, Brazil |
title_fullStr |
Emergence of aph(3’)-VI and accumulation of aminoglycoside modifying enzyme genes in KPC-2-possessing Enterobacter aerogenes isolates from infections and colonization in patients from Recife-PE, Brazil |
title_full_unstemmed |
Emergence of aph(3’)-VI and accumulation of aminoglycoside modifying enzyme genes in KPC-2-possessing Enterobacter aerogenes isolates from infections and colonization in patients from Recife-PE, Brazil |
title_sort |
emergence of aph(3’)-vi and accumulation of aminoglycoside modifying enzyme genes in kpc-2-possessing enterobacter aerogenes isolates from infections and colonization in patients from recife-pe, brazil |
publisher |
Sociedade Brasileira de Medicina Tropical (SBMT) |
url |
https://doi.org/10.1590/0037-8682-0460-2018 https://doaj.org/article/5cfd8e4e675948389758edd8a07ce018 |
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Arctic |
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Arctic |
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Arctic |
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Arctic |
op_source |
Revista da Sociedade Brasileira de Medicina Tropical, Vol 52 |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822019000100669&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/0037-8682-0460-2018 https://doaj.org/article/5cfd8e4e675948389758edd8a07ce018 |
op_doi |
https://doi.org/10.1590/0037-8682-0460-2018 |
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Revista da Sociedade Brasileira de Medicina Tropical |
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52 |
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