Importation of Entamoeba histolytica and predominance of Klebsiella pneumoniae in liver abscesses: a 7-year retrospective cohort study from the United Arab Emirates

• Published in: Tropical Diseases, Travel Medicine and Vaccines
• Main Authors: Hussam Mousa, Ghada Salameh Mohammed Al-Bluwi, Zainab Fathi Mohammed Al Drini, Huda Imam Gasmelseed, Jamal Aldeen Alkoteesh, Zahir Osman Eltahir Babiker
• Format: Article in Journal/Newspaper
• Language: English
• Published: BMC 2021
• Subjects: Cohort studies; Amoebic liver abscess; Pyogenic liver abscess; Klebsiella infections; Treatment outcome; United Arab Emirates; Arctic medicine. Tropical medicine; RC955-962; Arctic; Indian
• Online Access: https://doi.org/10.1186/s40794-021-00140-8; https://doaj.org/article/5cd8948f37424d5a865bf429e1ac13bf

Abstract Background There is a dearth of information on liver abscesses in the United Arab Emirates. Herein, we describe the clinical features of liver abscesses and determine their incidence rates and clinical outcomes. Methods We retrospectively reviewed the clinical charts of adult patients with a primary diagnosis of liver abscess at a major hospital over a 7-year period. Results Amongst 45 patients, 82.2% (37/45) had a pyogenic liver abscess (PLA) and 17.8% (8/45) had amoebic liver abscesses (ALA). Overall, patients were young (median age 42 years, IQR 35–52), mostly males (77.8%, 35/45) from the Indian subcontinent (55.6%, 25/45), presented with fever (88.9%, 40/45) and abdominal pain (88.9%, 40/45), and had a solitary abscess on imaging (71.1% (32/45). Crude annual incidence rates were 35.9/100,000 hospital admissions (95% CI 26.2–48.0) and 5.9/100,000 inhabitants (95% CI 4.3–7.9). All ALA patients were from the Indian subcontinent (100%, 8/8). Klebsiella pneumoniae was the most frequent pathogen in PLA (43.2% [16/37], 95% CI 27.1–60.5%). The hospital stay was shorter in ALA (7.5 days, IQR 7–8.5) than in PLA (14 days, IQR 9–17). No deaths were recorded within 30 days of hospitalisation. Conclusions ALA was exclusively seen in migrants from the Indian subcontinent, suggesting importation. Further research to characterise K. pneumoniae isolates and assess potential risk factors is needed.